{"id":39,"date":"2017-03-30T00:03:04","date_gmt":"2017-03-29T23:03:04","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/amarnath\/?page_id=39"},"modified":"2017-03-30T12:06:48","modified_gmt":"2017-03-30T11:06:48","slug":"our-research","status":"publish","type":"page","link":"https:\/\/blogs.ncl.ac.uk\/amarnath\/our-research\/","title":{"rendered":"Our research"},"content":{"rendered":"<p><strong>Overarching Focus of our Research:<\/strong><\/p>\n<p>Develop Novel Treg Cell Engineering Strategies For the Treatment of Inflammatory Disease<\/p>\n<p><strong>Research Goal in the Next Five Years<\/strong>:<\/p>\n<p>Decipher regulatory pathways crucial for Treg cell lineage maintenance<\/p>\n<p>Our research focus is directed towards a specific subset of CD4+ T cells namely regulatory T cells (Tregs). The reason we study this cell is because of its ability to induce tolerance and maintain immune homeostasis. Tregs are characterized by the expression of a nuclear factor FoxP3; deficiency of which results in IPEX syndrome in children. Therefore understanding Treg cell biology has real world implications.<\/p>\n<p>Given their importance in immune tolerance, Tregs can be used as a potential immunotherapeutic treatment for autoimmune diseases such as juvenile diabetes, Colitis, RA etc.<\/p>\n<p>In addition to their positive contributions towards immune homeostasis and autoimmunity, Tregs severely affect anti-tumor responses. Hence, understanding their biology will help in tailoring better cancer treatment strategies.<\/p>\n<p>In our laboratory, we are specifically investigating the role of co-receptor [in particular the PD-1\/PDL-1 signaling pathway] signaling in maintaining Treg cell lineage. A basic summary of some of the co-receptor expressed by T cells was nicely reviewed in Nature Reviews Immunology<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-67\" src=\"https:\/\/blogs.ncl.ac.uk\/amarnath\/files\/2017\/03\/co-receptor-231x300.jpg\" alt=\"co-receptor\" width=\"269\" height=\"346\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Overarching Focus of our Research: Develop Novel Treg Cell Engineering Strategies For the Treatment of Inflammatory Disease Research Goal in the Next Five Years: Decipher regulatory pathways crucial for Treg cell lineage maintenance Our research focus is directed towards a &hellip; <a href=\"https:\/\/blogs.ncl.ac.uk\/amarnath\/our-research\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1361,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-39","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ncl.ac.uk\/amarnath\/wp-json\/wp\/v2\/pages\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ncl.ac.uk\/amarnath\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ncl.ac.uk\/amarnath\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/amarnath\/wp-json\/wp\/v2\/users\/1361"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/amarnath\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":7,"href":"https:\/\/blogs.ncl.ac.uk\/amarnath\/wp-json\/wp\/v2\/pages\/39\/revisions"}],"predecessor-version":[{"id":69,"href":"https:\/\/blogs.ncl.ac.uk\/amarnath\/wp-json\/wp\/v2\/pages\/39\/revisions\/69"}],"wp:attachment":[{"href":"https:\/\/blogs.ncl.ac.uk\/amarnath\/wp-json\/wp\/v2\/media?parent=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}