{"id":35,"date":"2015-09-17T15:17:20","date_gmt":"2015-09-17T14:17:20","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/?page_id=35"},"modified":"2025-12-04T16:56:49","modified_gmt":"2025-12-04T16:56:49","slug":"publications","status":"publish","type":"page","link":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/our-research\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<p><\/p>\n\n\n<h2><strong>2025<\/strong><\/h2>\n<ul>\n<li>Hao Y, Lin H, Soul J, Overman LM, Lisgo SN, Coxhead J, Pir\u00f3g KA, Clark IM, Barter MJ, Reynard LN,\u00a0Young DA. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41242538\/\">Transcriptomic profiling confirms microRNA-140 is more functional in joint development than in disease<\/a>. <strong>Osteoarthritis Cartilage<\/strong>. 2025 Nov 14:S1063-4584(25)01229-4. doi: 10.1016\/j.joca.2025.11.005<\/li>\n<li>Farcasanu MV, Ruiz TLH, Brito FMJS, Soul J, Coxhead J, German MJ, Young DA, Ferreira-Duarte AM,\u00a0Pir\u00f3g KA. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40415244\/\">Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage<\/a>. <strong><em>Biotechnol Bioeng<\/em><\/strong>. 2025 May 25.\u00a0doi: 10.1002\/bit.29026<\/li>\n<li>Niu L, Swingler TE, Suelzu C, Ersek A, Orriss IR, Barter MJ, Hayman DJ,\u00a0Young DA, Horwood N, Clark IM. <a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39963339\/\" data-ga-category=\"result_click\" data-ga-action=\"5\" data-ga-label=\"39963339\" data-full-article-url=\"from_sort=date&amp;from_term=Young+DA&amp;from_cauthor_id=40415244&amp;from_pos=5\" data-article-id=\"39963339\">The microRNA-455 null mouse shows dysregulated bone turnover.<\/a> <em><strong>JBMR Plus<\/strong><\/em>. 2025 Jan 12;9(3):ziaf007. doi: 10.1093\/jbmrpl\/ziaf007<\/li>\n<li>Hayman DJ, Johnson de Sousa Brito FM, Lin H, Prior A, Charlesworth G, Hao Y, Pearson RD, Soul J, Clark IM, Pir\u00f3g KA,\u00a0Barter MJ, Van&#8217;t Hof RJ,\u00a0Young DA.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39383985\/\">microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity. <\/a><em><strong>Bone<\/strong><\/em>. 2025 Jan;190:117273. doi: 10.1016\/j.bone.2024.117273.<\/li>\n<\/ul>\n<h2><strong>2024<\/strong><\/h2>\n<ul>\n<li>McDonnell E, Orr SE,\u00a0Barter MJ, Rux D, Brumwell A, Wrobel N, Murphy L, Overman LM, Sorial AK,\u00a0Young DA, Soul J, Rice SJ. <a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39579763\/\" data-ga-category=\"result_click\" data-ga-action=\"1\" data-ga-label=\"39579763\" data-full-article-url=\"from_term=young+DA+barter+MJ&amp;from_sort=date&amp;from_pos=1\" data-article-id=\"39579763\">The methylomic landscape of human articular cartilage development contains epigenetic signatures of osteoarthritis risk.<\/a> Am J Hum Genet. 2024 Nov 14:S0002-9297(24)00386-0. doi: 10.1016\/j.ajhg.2024.10.017<\/li>\n<li>Patel K, Barter M, Soul J, Clark P, Proctor C, Clark I,\u00a0Young D,\u00a0Shanley DP. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39401064\/\">Systems analysis of miR-199a\/b-5p and multiple miR-199a\/b-5p targets during chondrogenesis<\/a>. <em><strong>Elife<\/strong><\/em>. 2024 Oct 14;12:RP89701. doi: 10.7554\/eLife.89701.<\/li>\n<li><span class=\"docsum-authors full-authors\">Gilbert SJ, Soul J, Hao Y, Lin H, Pir\u00f3g KA, Coxhead J, Patel K<strong>,<\/strong>\u00a0Barter MJ,\u00a0Young DA, Blain EJ.\u00a0 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39314058\/\">Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis mouse models.<\/a>\u00a0 <\/span><span class=\"docsum-journal-citation full-journal-citation\"><em><strong>Dis Model Mech<\/strong><\/em>. 2024 Sep 24:dmm.050583. doi: 10.1242\/dmm.050583.<\/span><\/li>\n<li>Barter MJ, Turner DA, Rice SJ, Hines M, Lin H, Falconer AMD, McDonnell E, Soul J, Arques MDC, Europe-Finner GN, Rowan AD,\u00a0Young DA, Wilkinson DJ. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39097037\/\">SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesis.<\/a> <em><strong>Matrix Biol<\/strong><\/em>. 2024 Nov;133:33-42. doi: 10.1016\/j.matbio.2024.07.004. Epub 2024 Aug 2.<\/li>\n<li>\n<div data-v-dc220f24=\"\" data-v-e8608732=\"\"><span class=\"pos_re\" data-v-dc220f24=\"\"><span class=\"el-popover__reference-wrapper\"><span class=\"author_name el-popover__reference\" data-v-dc220f24=\"\" aria-describedby=\"el-popover-3897\">Tamblin-Hopper<span style=\"font-size: 13.3333px\"> P, <\/span><\/span><\/span><\/span><span class=\"pos_re\" data-v-dc220f24=\"\"><span class=\"el-popover__reference-wrapper\"><span class=\"author_name el-popover__reference\" data-v-dc220f24=\"\" aria-describedby=\"el-popover-47\">Kiss-Toth<span style=\"font-size: 13.3333px\"> E, <\/span><\/span><\/span><\/span><span class=\"pos_re\" data-v-dc220f24=\"\"><span class=\"el-popover__reference-wrapper\"><span class=\"author_name el-popover__reference\" data-v-dc220f24=\"\" aria-describedby=\"el-popover-6613\">Sudbery I,\u00a0 <\/span><\/span><\/span><span class=\"pos_re\" data-v-dc220f24=\"\"><span class=\"el-popover__reference-wrapper\"><span class=\"author_name el-popover__reference\" data-v-dc220f24=\"\" aria-describedby=\"el-popover-6708\">Young<span style=\"font-size: 13.3333px\"> DA, <\/span><\/span><\/span><\/span><span class=\"pos_re\" data-v-dc220f24=\"\"><span class=\"pos_re\" data-v-dc220f24=\"\"><span class=\"el-popover__reference-wrapper\"><span class=\"author_name el-popover__reference\" data-v-dc220f24=\"\" aria-describedby=\"el-popover-5584\">Wilkinson JM. <\/span><\/span><\/span><\/span><span style=\"font-size: revert\"><a href=\"https:\/\/www.oaepublish.com\/articles\/jtgg.2024.12?utm_campaign=website&amp;utm_medium=email&amp;utm_source=sendgrid.com\">The potential therapeutic applications of long non-coding RNAs<\/a>. <em><strong>J Transl Genet Genom<\/strong><\/em> 2024;8:225-43. <a href=\"https:\/\/doi.org\/10.20517\/jtgg.2024.12\" target=\"_blank\" rel=\"noopener\" data-v-e8608732=\"\">10.20517\/jtgg.2024.12<\/a>\u00a0<\/span><\/div>\n<\/li>\n<\/ul>\n<h2><strong>2023<\/strong><\/h2>\n<ul>\n<li>G\u00f3mez R, Barter MJ, Alonso-P\u00e9rez A, Skelton AJ, Proctor C, Herrero-Beaumont G, Young DA. <a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36890579\/\" data-ga-category=\"result_click\" data-ga-action=\"0\" data-ga-label=\"36890579\">DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation.\u00a0<\/a><em><strong>Biol Res<\/strong><\/em>. 2023 Mar 8;56(1):9. doi: 10.1186\/s40659-023-00417-6.<\/li>\n<\/ul>\n<h2><strong>2022<\/strong><\/h2>\n<ul>\n<li>Barter MJ, Butcher A, Wang H, Tsompani D, Galler M, Rumsby EL, Culley KL, Clark IM, Young DA.\u00a0 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35459919\/\">HDAC6 regulates NF-\u03baB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression<\/a>. <em><strong>Sci Rep<\/strong>.<\/em> 2022 Apr 22;12(1):6640. doi: 10.1038\/s41598-022-10518-z.<\/li>\n<li>Chaudhry N, Muhammad H, Seidl C, Downes D,\u00a0Young DA, Hao Y, Zhu L, Vincent TL. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35074547\/\">Highly efficient CRISPR-Cas9-mediated editing identifies novel mechanosensitive microRNA-140 targets in primary human articular chondrocytes.<\/a> <em><strong>Osteoarthritis Cartilage.<\/strong><\/em> 2022 Jan 21:S1063-4584(22)00009-7. doi: 10.1016\/j.joca.2022.01.005. Online ahead of print.<\/li>\n<li>Young DA, Barter MJ, Soul J. <a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34774787\/\" data-ga-category=\"result_click\" data-ga-action=\"1\" data-ga-label=\"34774787\" data-full-article-url=\"from_term=young+DA+newcastle&amp;from_sort=date&amp;from_pos=1\" data-article-id=\"34774787\">Osteoarthritis year in review: genetics, genomics, epigenetics. <\/a><em><strong>Osteoarthritis Cartilage<\/strong><\/em>.\u00a02022 Feb;30(2):216-225. doi: 10.1016\/j.joca.2021.11.004. Epub 2021 Nov 11.<\/li>\n<\/ul>\n<h2><strong>2021<\/strong><\/h2>\n<ul>\n<li>Wilkinson DJ, Falconer AMD, Wright HL, Lin H, Yamamoto K, Cheung K, Charlton SH, Arques MDC, Janciauskiene S, Refaie R, Rankin KS,\u00a0Young DA, Rowan AD.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34270864\/\"> Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.<\/a> <em><strong>FEBS J<\/strong><\/em>. 2021 Jul 16. doi: 10.1111\/febs.16127.<\/li>\n<li>Jones TL, Esa MS, Li KHC, Krishnan SRG, Elgallab GM, Pearce MS, Young DA, Birrell FN. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34166859\/\">Osteoporosis, fracture, osteoarthritis &amp; sarcopenia: A systematic review of circulating microRNA association.<\/a> <em><strong>Bone<\/strong><\/em>. 2021 Jun 21:116068. doi: 10.1016\/j.bone.2021.116068.<\/li>\n<li>Hayman DJ, Modebadze T, Charlton S, Cheung K, Soul J, Lin H, Hao Y, Miles CG, Tsompani D, Jackson RM, Briggs MD, Pir\u00f3g KA, Clark IM,\u00a0Barter MJ, Clowry GJ, LeBeau FEN,\u00a0Young DA. <a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34001919\/\" data-ga-category=\"result_click\" data-ga-action=\"1\" data-ga-label=\"34001919\" data-full-article-url=\"from_term=young+DA+barter+MJ&amp;from_sort=pubdate&amp;from_size=20&amp;from_pos=1\" data-article-id=\"34001919\">Increased hippocampal excitability in miR-324-null mice.<\/a> <em><strong>Sci Rep<\/strong><\/em>. 2021 May 17;11(1):10452. doi: 10.1038\/s41598-021-89874-1.<\/li>\n<li>Patel K, Chandrasegaran S,\u00a0Clark IM, Proctor CJ,\u00a0Young DA, Shanley DP.\n<div class=\"docsum-wrap\">\n<div class=\"docsum-content\"><a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33993215\/\" data-ga-category=\"result_click\" data-ga-action=\"2\" data-ga-label=\"33993215\" data-full-article-url=\"from_term=young+DA+clark+IM&amp;from_sort=pubdate&amp;from_size=20&amp;from_pos=2\" data-article-id=\"33993215\">TimiRGeN: R\/Bioconductor package for time series microRNA-mRNA integration and analysis.<\/a> <em><strong>Bioinformatics<\/strong><\/em>. 2021 May 16:btab377. doi: 10.1093\/bioinformatics\/btab377<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<h2><strong>2020<\/strong><\/h2>\n<ul>\n<li>Le L, Niu L, Barter MJ,\u00a0Young DA, Dalmay T, Clark IM, Swingler TE. <a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33318505\/\" data-ga-category=\"result_click\" data-ga-action=\"1\" data-ga-label=\"33318505\" data-full-article-url=\"from_term=young+DA%5BAU%5D&amp;from_sort=date&amp;from_pos=1\" data-article-id=\"33318505\">The role of microRNA-3085 in chondrocyte function.<\/a> <em><strong>Sci Rep<\/strong><\/em>. 2020 Dec 14;10(1):21923. doi: 10.1038\/s41598-020-78606-6.<\/li>\n<li><span class=\"docsum-authors full-authors\">Soul J, Barter MJ, Little CB, Young DA. <\/span><a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33077471\/\" data-ga-category=\"result_click\" data-ga-action=\"2\" data-ga-label=\"33077471\" data-full-article-url=\"from_term=young+DA&amp;from_sort=date&amp;from_pos=2\" data-article-id=\"33077471\">OATargets: a knowledge base of genes associated with osteoarthritis joint damage in animals.<\/a> <span class=\"docsum-journal-citation full-journal-citation\"><em><strong>Ann Rheum Dis<\/strong><\/em>. 2020 Oct 19:annrheumdis-2020-218344. doi: 10.1136\/annrheumdis-2020-218344.<\/span><\/li>\n<li><span class=\"docsum-authors full-authors\">Stadnik PS, Gilbert SJ, Tarn J, Charlton S, Skelton AJ, Barter MJ, Duance VC,\u00a0Young DA, Blain EJ. <\/span><a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33052608\/\" data-ga-category=\"result_click\" data-ga-action=\"4\" data-ga-label=\"33052608\" data-full-article-url=\"from_term=young+DA&amp;from_sort=date&amp;from_pos=4\" data-article-id=\"33052608\">Regulation of microRNA-221, -222, -21 and -27 in articular cartilage subjected to abnormal compressive forces.<\/a><span class=\"docsum-journal-citation full-journal-citation\"><em><strong>J Physiol<\/strong><\/em>. 2020 Oct 14. doi: 10.1113\/JP279810. Online ahead of print<\/span><\/li>\n<li><span class=\"docsum-authors full-authors\">Barter MJ, Cheung K, Falk J, Panagiotopoulos AC, Cosimini C, O&#8217;Brien S, Teja-Putri K, Neill G, Deehan DJ, Young DA<b>. <\/b><\/span><a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32741307\/\" data-ga-category=\"result_click\" data-ga-action=\"1\" data-ga-label=\"32741307\" data-full-article-url=\"from_term=young+DA+barter+MJ&amp;from_sort=date&amp;from_pos=1\" data-article-id=\"32741307\">Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation.<\/a><span class=\"docsum-journal-citation full-journal-citation\"><em><strong> Epigenetics<\/strong><\/em>. 2020 Aug 2:1-14. doi: 10.1080\/15592294.2020.1789266. Online ahead of print.<\/span><span class=\"citation-part\">PMID:\u00a0<span class=\"docsum-pmid\">32741307<\/span><\/span><\/li>\n<li>Woods S, Charlton S, Cheung K, Hao Y, Soul J, Reynard LN, Crowe N, Swingler TE, Skelton AJ, Pir\u00f3g KA, Miles CG, Tsompani D, Jackson RM, Dalmay T, Clark IM, Barter MJ, Young DA.<a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32660984\/\" data-ga-category=\"result_click\" data-ga-action=\"1\" data-ga-label=\"32660984\" data-full-article-url=\"from_term=young+DA&amp;from_sort=date&amp;from_pos=1\" data-article-id=\"32660984\">microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs.\u00a0<\/a><em><strong>RNA<\/strong><\/em>. 2020 Jul 13:rna.075176.120. doi: 10.1261\/rna.075176.120.<\/li>\n<li>Rice SJ, Beier F, Young DA, Loughlin J. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32273577\">Interplay between genetics and epigenetics in osteoarthritis.<\/a> <em><strong>Nat Rev Rheumatol<\/strong><\/em>. 2020 Apr 9. doi: 10.1038\/s41584-020-0407-3. Review.<\/li>\n<li>Dennis EP, Edwards SM, Jackson RM, Hartley CL, Tsompani D, Capulli M, Teti A, Boot-Handford RP,\u00a0Young DA, Pir\u00f3g KA, Briggs MD. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32181934\">CRELD2 is a novel LRP1 chaperone that regulates non-canonical WNT signalling in skeletal development.<\/a> <em><strong><span class=\"jrnl\" title=\"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\">J Bone Miner Res<\/span><\/strong><\/em>. 2020 Mar 17. doi: 10.1002\/jbmr.4010.<\/li>\n<li>Cheung K, Barter MJ, Falk J, Proctor CJ, Reynard LN, Young DA. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32058623\">Histone ChIP-Seq identifies differential enhancer usage during chondrogenesis as critical for defining cell-type specificity.<\/a><em><strong><span class=\"jrnl\" title=\"FASEB journal : official publication of the Federation of American Societies for Experimental Biology\"> FASEB J<\/span><\/strong><\/em>. 2020 Feb 14. doi: 10.1096\/fj.201902061RR.<\/li>\n<li>Barter MJ, Bui C, Cheung K, Falk J, G\u00f3mez R, Skelton AJ, Elliott HR, Reynard LN, Young DA. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31980739\">DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions.<\/a> <em><strong><span class=\"jrnl\" title=\"Scientific reports\">Sci Rep<\/span><\/strong><\/em>. 2020 Jan 24;10(1):1169. doi: 10.1038\/s41598-020-58093-5.<\/li>\n<\/ul>\n<h2><strong>2019<\/strong><\/h2>\n<ul>\n<li>Cheung K, Burgers MJ,\u00a0Young DA, Cockell S, Reynard LN. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31833794\">Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage. <\/a><em><strong><span class=\"jrnl\" title=\"Epigenetics\">Epigenetics<\/span><\/strong><\/em>. 2019 Dec 13:1-10. doi: 10.1080\/15592294.2019.1700003.<\/li>\n<li>Swingler TE, Niu L, Smith P, Paddy P, Le L, Barter MJ,\u00a0Young\u00a0DA,\u00a0Clark IM. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31621575\">The function of microRNAs in cartilage and osteoarthritis<\/a>. <em><strong><span class=\"jrnl\" title=\"Clinical and experimental rheumatology\">Clin Exp Rheumatol<\/span><\/strong><\/em>. 2019 Sep-Oct;37 Suppl 120(5):40-47. Epub 2019 Oct 15. Review.<\/li>\n<li>Coelho-Lima J, Mohammed A, Cormack S, Jones S, Ali A, Panahi P,\u00a0Barter M, Bagnall A, Ali S,\u00a0Young D, Spyridopoulos I. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31672851\">Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion.<\/a><em><strong><span class=\"jrnl\" title=\"Clinical chemistry\"> Clin Chem<\/span><\/strong><\/em>. 2019 Oct 31. pii: clinchem.2019.308353. doi: 10.1373\/clinchem.2019.308353.<\/li>\n<li>Young DA, Barter MJ, Wilkinson DJ. <a href=\"https:\/\/doi.org\/10.12688\/f1000research.17471.1\">Recent advances in understanding the regulation of metalloproteinases<\/a>.\u00a0<strong><i>F1000Research<\/i>\u00a0<\/strong>2019,\u00a0<b>8<\/b>(F1000 Faculty Rev):195<\/li>\n<li>Ajekigbe B, Cheung K, Xu Y, Skelton AJ, Panagiotopoulos A, Soul J, Hardingham TE, Deehan DJ, Barter MJ,\u00a0Young DA.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30611906\">Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage.<\/a>\u00a0<em><strong><span class=\"jrnl\" title=\"Osteoarthritis and cartilage\">Osteoarthritis Cartilage<\/span><\/strong><\/em>. 2019 Jan 3. pii: S1063-4584(18)31594-2. doi: 10.1016\/j.joca.2018.12.015.<\/li>\n<\/ul>\n<h2><strong>2018<\/strong><\/h2>\n<ul>\n<li>Woods S, Barter MJ, Elliott HR, McGillivray CM, Birch MA, Clark IM,\u00a0Young DA. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30193893\">miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse.<\/a>\u00a0<em><strong><span class=\"jrnl\" title=\"Matrix biology : journal of the International Society for Matrix Biology\">Matrix Biol<\/span><\/strong><\/em>. 2018 Sep 5. pii: S0945-053X(18)30200-2. doi:10.1016\/j.matbio.2018.08.009.<\/li>\n<\/ul>\n<h2><strong>2017<\/strong><\/h2>\n<ul>\n<li>Barter MJ, G<span style=\"color: #000000\"><span style=\"color: #000000\">omez R, Hyatt S, Cheung K, Skelton A, Xu Y, Clark I, Young DA. \u00a0<\/span><\/span>\n<div class=\"docsum-wrap\">\n<div class=\"docsum-content\"><a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29084806\/\" data-ga-category=\"result_click\" data-ga-action=\"13\" data-ga-label=\"29084806\" data-full-article-url=\"from_term=young+DA+barter+MJ&amp;from_sort=pubdate&amp;from_size=20&amp;from_pos=13\" data-article-id=\"29084806\">The long non-coding RNA\u00a0<em>ROCR<\/em> contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells<\/a><span style=\"color: #3366ff\" role=\"menubar\"><a title=\"Development (Cambridge, England).\" role=\"menuitem\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29084806#\">.<\/a><\/span><strong><em> Development<\/em> <\/strong><span style=\"color: #000000\">2017 Dec 15;144(24):4510-4521. doi: 10.1242\/dev.152504. Epub 2017 Oct 30.<\/span><\/div>\n<\/div>\n<\/li>\n<li id=\"publication:237006\">Steinbusch MMF, Fang Y, Milner PI, Clegg PD, Young DA, Welting TJM, Peffers MJ. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#237006\">Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis<\/a>. <strong><em>Scientific Reports<\/em><\/strong> 2017, <strong>7<\/strong>, 43558.<\/li>\n<\/ul>\n<h2><strong>2016<\/strong><\/h2>\n<ul>\n<li id=\"publication:222803\">Crowe N, Swingler TE, Le LTT, Barter MJ, Wheeler G, Pais H, Donell ST, Young DA, Dalmay T, Clark IM. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#222803\">Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA<\/a>. <strong><em>Osteoarthritis and Cartilage<\/em><\/strong> 2016, <strong>24<\/strong>(3), 534-543.<\/li>\n<li id=\"publication:225772\">Le LTT, Swingler TE, Crowe N, Vincent TL, Barter MJ, Donell ST, Delany AM, Dalmay T, Young DA, Clark IM. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#225772\">The microRNA-29 family in cartilage homeostasis and osteoarthritis<\/a>. <strong><em>Journal of Molecular Medicine<\/em><\/strong> 2016, <strong>94<\/strong>(5), 583-596.<\/li>\n<\/ul>\n<h2><strong>2015<\/strong><\/h2>\n<ul>\n<li id=\"publication:212880\">Rushton MD, Young DA, Loughlin J, Reynard LN. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#212880\">Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients<\/a>. <strong><em>Annals of the Rheumatic Diseases<\/em><\/strong> 2015, <strong>74<\/strong>(9), 1778-1782.<\/li>\n<li id=\"publication:214090\">Barter MJ, Tselepi M, Gomez R, Woods S, Hui W, Smith GR, Shanley DP, Clark IM, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#214090\">Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p<\/a>. <strong><em>Stem Cells<\/em> <\/strong>2015, <strong>33<\/strong>(11), 3266-3280.<\/li>\n<li id=\"publication:216703\">Rushton MD, Reynard LN, Young DA, Shepherd C, Aubourg G, Gee F, Darlay R, Deehan D, Cordell HJ, Loughlin J. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#216703\">Methylation quantitative trait locus (meQTL) analysis of osteoarthritis links epigenetics with genetic risk<\/a>. <strong><em>Human Molecular Genetics<\/em><\/strong> 2015, <strong>24<\/strong>(25), 7432-7444.<\/li>\n<\/ul>\n<h2><strong>2014 and earlier<\/strong><\/h2>\n<ul>\n<li id=\"publication:206030\">Purvis HA, Anderson AE, Young DA, Isaacs JD, Hilkens CMU. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#206030\">A Negative Feedback Loop Mediated by STAT3 Limits Human Th17 Responses<\/a>. <em>J<strong>ournal of Immunology<\/strong><\/em> 2014, <strong>193<\/strong>(3), 1142-1150.<\/li>\n<li id=\"publication:198412\">Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, Young DA, Loughlin J. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#198412\">Characterization of the cartilage DNA methylome in knee and hip osteoarthritis<\/a>. <strong><em>Arthritis &amp; Rheumatology<\/em><\/strong> 2014, <strong>66<\/strong>(9), 2450\u20132460.<\/li>\n<li id=\"publication:206802\">Litherland GJ, Hui W, Elias MS, Wilkinson DJ, Watson S, Huesa C, Young DA, Rowan AD. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#206802\">Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis<\/a>. <strong><em>Arthritis &amp; Rheumatology<\/em><\/strong> 2014, <strong>66<\/strong>(8), 2175-2187.<\/li>\n<li id=\"publication:208663\">Hui W, Young DA, Rowan AD, Xu X, Cawston TE, Proctor CJ. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#208663\">Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage<\/a>. <strong><em>Annals of the Rheumatic Diseases<\/em><\/strong> 2014, 1-10.<\/li>\n<li id=\"publication:212529\">Radwan M, Wilkinson DJ, Hui W, Destrument AP, Charlton SH, Barter MJ, Gibson B, Coulombe J, Gray DA, Rowan AD, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#212529\">Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination<\/a>. <strong><em>Annals of the Rheumatic Diseases<\/em><\/strong> 2014.<\/li>\n<li id=\"publication:204078\">Barter MJ, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#204078\">Epigenetic Mechanisms and Non-coding RNAs in Osteoarthritis<\/a>. <em>Current Rheumatology Reports<\/em> 2013, <strong>15<\/strong>(9), 353.<\/li>\n<li id=\"publication:190026\">Radwan M, Gavriilidis C, Robinson JH, Davidson R, Clark IM, Rowan AD, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#190026\">Matrix metalloproteinase-13 expression in response to double-stranded RNA in human chondrocytes<\/a>. <strong><em>Arthritis &amp; Rheumatism<\/em><\/strong> 2013, <strong>65<\/strong>(5), 1290-1301.<\/li>\n<li id=\"publication:188883\">Gavriilidis C, Miwa S, von Zglinicki T, Taylor RW, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#188883\">Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2<\/a>.<strong> <em>Arthritis &amp; Rheumatism<\/em><\/strong> 2013, <strong>65<\/strong>(2), 378-387.<\/li>\n<li id=\"publication:190028\">Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#190028\">More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis<\/a>. <strong><em>Arthritis and Rheumatism<\/em><\/strong> 2013, <strong>65<\/strong>(3), 555-558.<\/li>\n<li id=\"publication:193373\">Syddall CM, Reynard LN, Young DA, Loughlin J. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#193373\">The Identification of <em>Trans<\/em>-acting Factors That Regulate the Expression of <em>GDF5<\/em> via the Osteoarthritis Susceptibility SNP rs143383<\/a>. <strong><em>PLoS Genetics<\/em><\/strong> 2013, <strong>9<\/strong>(6), e1003557.<\/li>\n<li id=\"publication:185029\">Pratt AG, Swan DC, Richardson S, Wilson G, Hilkens C, Young DA, Isaacs JD. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#185029\">A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly anti-citrullinated peptide antibody-negative disease<\/a>. <strong><em>Annals of the Rheumatic Diseases<\/em><\/strong> 2012, <strong>71<\/strong>(8), 1374-1381.<\/li>\n<li id=\"publication:186452\">Bui C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#186452\">cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis<\/a>. <strong><em>FASEB Journal<\/em><\/strong> 2012, <strong>26<\/strong>(7), 3000-3011.<\/li>\n<li id=\"publication:185455\">Barter MJ, Bui C, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#185455\">Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs<\/a>. <strong><em>Osteoarthritis and Cartilage<\/em><\/strong> 2012, <strong>20<\/strong>(5), 339-349.<\/li>\n<li id=\"publication:188416\">Xu Y, Barter MJ, Swan DC, Rankin KS, Rowan AD, Santibanez-Koref M, Loughlin J, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#188416\">Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA<\/a>. <strong><em>Osteoarthritis and Cartilage<\/em><\/strong> 2012, <strong>20<\/strong>(9), 1029-1038.<\/li>\n<li id=\"publication:183525\">Hui W, Litherland GJ, Elias MS, Kitson GI, Cawston TE, Rowan AD, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#183525\">Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases<\/a>.<strong> <em>Annals of the Rheumatic Diseases<\/em><\/strong> 2012, <strong>71<\/strong>(3), 455-462.<\/li>\n<li id=\"publication:183414\">Swingler TE, Wheeler G, Carmont V, Elliott HR, Barter MJ, Abu-Elmagd M, Donell ST, Boot-Handford RP, Hajihosseini MK, M\u00fcnsterberg A, Dalmay T, Young DA, Clark IM. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#183414\">The expression and function of microRNAs in chondrogenesis and osteoarthritis<\/a>. <strong><em>Arthritis and Rheumatism<\/em><\/strong> 2012, <strong>64<\/strong>(6), 1909-1919.<\/li>\n<li id=\"publication:190027\">Young DA, Bui C, Barter MJ. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#190027\">Understanding CpG methylation in the context of osteoarthritis<\/a>. <em>Epigenomics<\/em> 2012, <strong>4<\/strong>(6), 593-595.<\/li>\n<li id=\"publication:177381\">Reynard LN, Bui C, Canty-Laird EG, Young DA, Loughlin J. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#177381\">Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation<\/a>. <strong><em>Human Molecular Genetics<\/em><\/strong> 2011, <strong>20<\/strong>(17), 3450-3460.<\/li>\n<li id=\"publication:156000\">Cui Y, Yu J, Urban JPG, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#156000\">Differential Gene Expression Profiling of Metalloproteinases and Their Inhibitors A Comparison Between Bovine Intervertebral Disc Nucleus Pulposus Cells and Articular Chondrocytes<\/a>. <strong><em>Spine<\/em> <\/strong>2010, <strong>35<\/strong>(11), 1101-1108.<\/li>\n<li id=\"publication:167912\">Barter MJ, Pybus L, Litherland GJ, Rowan AD, Clark IM, Edwards DR, Cawston TE, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#167912\">HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes<\/a>. <strong><em>Matrix Biology<\/em> <\/strong>2010, <strong>29<\/strong>(7), 602-612.<\/li>\n<li id=\"publication:168162\">Barter MJ, Hui W, Lakey RL, Catterall JB, Cawston TE, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#168162\">Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation<\/a>. <strong><em>Annals of the Rheumatic Diseases<\/em> <\/strong>2010, <strong>69<\/strong>(12), 2189-2198.<\/li>\n<li id=\"publication:167484\">Hui W, Litherland GJ, Jefferson M, Barter MJ, Elias MS, Cawston TE, Rowan AD, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#167484\">Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway<\/a>. <strong><em>Rheumatology<\/em> <\/strong>2010, <strong>49<\/strong>(11), 2043-2053.<\/li>\n<li id=\"publication:157475\">Milner JM, Patel A, Davidson RK, Swingler TE, Desilets A, Young DA, Kelso EB, Donell ST, Cawston TE, Clark IM, Ferrell WR, Plevin R, Lockhart JC, Leduc R, Rowan AD. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#157475\">Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis<\/a>. <strong><em>Arthritis &amp; Rheumatism<\/em><\/strong> 2010, <strong>62<\/strong>(7), 1955-1966.<\/li>\n<li id=\"publication:155759\">Swingler TE, Kevorkian L, Culley KL, Illman SA, Young DA, Parker AE, Lohi J, Clark IM. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#155759\">MMP28 gene expression is regulated by Sp1 transcription factor acetylation<\/a>. <strong><em>Biochemical Journal<\/em> <\/strong>2010, <strong>427<\/strong>, 391-400.<\/li>\n<li id=\"publication:154329\">Cawston TE, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#154329\">Proteinases involved in matrix turnover during cartilage and bone breakdown<\/a>. <strong><em>Cell and Tissue Research<\/em><\/strong> 2010, <strong>339<\/strong>(1), 221-235.<\/li>\n<li id=\"publication:157621\">Scott JL, Gabrielides C, Davidson RK, Swingler TE, Clark IM, Wallis GA, Boot-Handford RP, Kirkwood TBL, Talyor RW, Young DA. <a title=\"view complete information on this publication\" href=\"http:\/\/www.ncl.ac.uk\/igm\/staff\/profile\/davidyoung.html#157621\">Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease<\/a>. <strong><em>Annals of the Rheumatic Diseases<\/em><\/strong> 2010, <strong>69<\/strong>(8), 1502-1510.<\/li>\n<\/ul>\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2025 Hao Y, Lin H, Soul J, Overman LM, Lisgo SN, Coxhead J, Pir\u00f3g KA, Clark IM, Barter MJ, Reynard LN,\u00a0Young DA. Transcriptomic profiling confirms microRNA-140 is more functional in joint development than in disease. Osteoarthritis Cartilage. 2025 Nov 14:S1063-4584(25)01229-4. doi: 10.1016\/j.joca.2025.11.005 Farcasanu MV, Ruiz TLH, Brito FMJS, Soul J, Coxhead J, German MJ, Young &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/blogs.ncl.ac.uk\/davidyoung\/our-research\/publications\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Publications&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1230,"featured_media":87,"parent":14,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-35","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/wp-json\/wp\/v2\/pages\/35","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/wp-json\/wp\/v2\/users\/1230"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/wp-json\/wp\/v2\/comments?post=35"}],"version-history":[{"count":40,"href":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/wp-json\/wp\/v2\/pages\/35\/revisions"}],"predecessor-version":[{"id":369,"href":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/wp-json\/wp\/v2\/pages\/35\/revisions\/369"}],"up":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/wp-json\/wp\/v2\/pages\/14"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/wp-json\/wp\/v2\/media\/87"}],"wp:attachment":[{"href":"https:\/\/blogs.ncl.ac.uk\/davidyoung\/wp-json\/wp\/v2\/media?parent=35"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}