Opens: 30/07/18
Deadline: 09/10/18
Amount: £600k (£3m total budget)
Duration: 36 months
The Medical Research Council (MRC) and the National Institute for Health Research (NIHR) are issuing a joint call for research projects into disease clustering in multimorbidity.
Funding is being made available for exploratory or hypothesis-driven research that will systematically identify or explore common disease clusters, their distributions in diverse groups, multimorbidity trajectories and/or underpinning mechanisms across the life course.
The call aims to support integrative population and patient studies using existing infrastructure and data sources including established cohorts, surveys, biobanks, and primary and secondary care data to identify new clusters of multimorbidity, biological, environmental, behavioural and socioeconomic multimorbidity risk factors, biomarkers and disease associations underpinned by common mechanistic pathways or induced by a pre-existing condition or its treatment.
Applications are considered that will contribute to building the evidence base for more focused research on specific types of multimorbidity or will generate data to enable larger-scale experimental medicine and stratified medicine studies.
Awards are expected to help establish new and galvanise existing research collaborations between clinical and academic experts from different research fields.
The scope of the call includes but is not limited to the following research topics:
- Disease clustering in defined population/patient groups.
- Addressing prevalence and changes in multimorbidity during the life course (e.g. in childhood, during pregnancy or postpartum period).
- Social patterning and health inequalities associated with multimorbidity.
- Shared mechanistic pathways in common co-morbidities.
- Multimorbidity biomarkers, early predictors and genetic associations.
- Innovative methodological approaches, tools and technologies for capturing and measuring patients’ complexities in the context of multimorbidity.
- Enriching data for established population and clinical cohorts.
Proposals can only be led by an eligible UK-based Principal Investigator.
Overseas Co-investigators are permitted as long as the focus of a proposal is on the UK population.