{"id":523,"date":"2018-08-28T15:51:45","date_gmt":"2018-08-28T14:51:45","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/icmresearchfunding\/?p=523"},"modified":"2018-08-28T15:51:45","modified_gmt":"2018-08-28T14:51:45","slug":"mrc-immune-mediated-inflammatory-diseases-imids-understanding-common-mechanisms","status":"publish","type":"post","link":"https:\/\/blogs.ncl.ac.uk\/icmresearchfunding\/2018\/08\/28\/mrc-immune-mediated-inflammatory-diseases-imids-understanding-common-mechanisms\/","title":{"rendered":"MRC Immune-mediated inflammatory diseases (IMIDs): understanding common mechanisms"},"content":{"rendered":"<p><strong>28 September 2018, 4pm (Expressions of Interest) <\/strong>Full applications will be invited and assessed in March 2019<\/p>\n<p><strong>MRC Immune-mediated inflammatory diseases (IMIDs): understanding common mechanisms<\/strong><\/p>\n<p><a href=\"https:\/\/mrc.ukri.org\/funding\/browse\/immune-mediated-inflammatory-diseases\/immune-mediated-inflammatory-diseases-understanding-common-mechanisms\/\">https:\/\/mrc.ukri.org\/funding\/browse\/immune-mediated-inflammatory-diseases\/immune-mediated-inflammatory-diseases-understanding-common-mechanisms\/<\/a><\/p>\n<p>Up to \u00a31 million is available for awards of up to \u00a3200,000 (80% fEC value), for up to 24 months are available for exploratory or hypothesis-driven research that will systematically identify or explore common diseases mechanisms across multiple IMIDs.<\/p>\n<p>The call aims to provide funds to support mechanistic studies using existing infrastructure and data sources including established cohorts, surveys, biobanks, and primary and secondary care data to:<\/p>\n<ul>\n<li>identify new mechanisms which are shared across multiple IMIDs<\/li>\n<li>evaluate the environmental impact on genetic predisposition to IMIDs<\/li>\n<li>investigate immunological tolerance within IMIDs<\/li>\n<li>explore the interplay between microbiota and IMIDs<\/li>\n<li>examine the organ specificity of some IMIDs.<\/li>\n<\/ul>\n<p>They will consider applications that will contribute to building the evidence base for more focused research on specific types of IMIDs or will generate data to enable larger-scale experimental medicine and stratified medicine studies.<br \/>\nAwards are expected to help establish new and galvanise existing research collaborations between clinical and academic experts from different research fields.<\/p>\n<p>The scope of the call includes, but is not limited to the following research topics:<\/p>\n<ul>\n<li>IMID clustering in defined population\/patient groups<\/li>\n<li>addressing prevalence and changes in IMIDs during the life course (such as in childhood, during pregnancy or postpartum period)<\/li>\n<li>biomedical drivers of IMIDs<\/li>\n<li>shared mechanistic pathways in IMIDs<\/li>\n<li>IMID biomarkers, early predictors and genetic associations<\/li>\n<li>innovative methodological approaches, tools and technologies for capturing and measuring patients&#8217; complexities in the context of IMIDs<\/li>\n<li>enriching data for established population and clinical cohorts.<\/li>\n<\/ul>\n<p>Cross-disciplinary and cross-institutional teams are encouraged involving clinicians, epidemiologists, data scientists, social and behavioural scientists, and basic biomedical researchers to tackle the complexity of IMIDs at all levels.<\/p>\n<p>Additionally, in order to build capacity in this area of research, applications from early-stage career researchers are particularly welcomed.<\/p>\n<p>Queries re the remit of the call should be sent to <a href=\"mailto:imid@mrc.ukri.org\">imid@mrc.ukri.org<\/a><\/p>\n<p>The EoI form is to be converted to pdf and submitted by email to <a href=\"mailto:martin.broadstock@headoffice.mrc.ac.uk\">martin.broadstock@headoffice.mrc.ac.uk<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>28 September 2018, 4pm (Expressions of Interest) Full applications will be invited and assessed in March 2019 MRC Immune-mediated inflammatory diseases (IMIDs): understanding common mechanisms https:\/\/mrc.ukri.org\/funding\/browse\/immune-mediated-inflammatory-diseases\/immune-mediated-inflammatory-diseases-understanding-common-mechanisms\/ Up to \u00a31 million is available for awards of up to \u00a3200,000 (80% fEC &hellip; 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