Welcome to the blog of the Pirog lab at Newcastle University.
We are a vibrant goup researching rare and common skeletal diseases. We use cellular, tissue engineered, and animal models to gain more understanding of pathobiology of chondrodysplasias and osteoarthritis, and learn more about healthy skeletal development and ageing. We are specifically interested in the abnormalities in the extracellular matrix production and ultrastructure, in how the cells sense and react to such changes and how this in turn impacts on the biomechanical properties of tissues. We’re also interested in musculoskeletal complications associated with rare and common skeletal diseases, such as myopathy and tendinopathy, trying to perceive the joint as a system of various interconnected tissues and through this approach gain a broader understanding of skeletal complications.