Publications

Patents

  • Al Musaimi, O.; Williams, D. R. Solution Phase Peptide Synthesis; I.P. Office, Ed.; Imperial College Innovations Limited: London, PCT/GB2025/051451, UK, 2025.
  • Al Musaimi, O.; Williams, D. R. Methods of Chemical Synthesis of Oligonucleotides; I.P. Office, Ed.; Imperial College Innovations Limited: London, 2415649.9, UK, 2024
  • Al Musaimi, O.; Williams, D. R. Methods of Chemical Synthesis of Peptides; I.P. Office, Ed.; Imperial College Innovations Limited: London, UK, WO2024261319A1, 07/12/2024
  • Al Musaimi, O.; Williams, D. R. Solution Phase Peptide Synthesis; I.P. Office, Ed.; Imperial College Innovations Limited: London, GB2409647.1, UK, 2024.
  • Al Musaimi, O.; Williams, D. R. Methods of Chemical Synthesis of Peptides; I.P. Office, Ed.; Imperial College Innovations Limited: London, GB2312735.0, UK, 2023.

Articles

  1. Nsereko, Y., Armstrong, A., Coburn, F., and Al Musaimi, O.* Innovative Peptide Therapeutics in the Pipeline: Transforming Cancer Detection and Treatment. Int. J. Mol. Sci., 2025. 26, DOI: 10.3390/ijms26146815.
  2. Coburn, F., Nsereko, Y., Armstrong, A., and Al Musaimi, O.* Peptide inhibitors: Breaking cancer code. Eur. J. Med. Chem. 2025, 297: p. 117961. 10.1016/j.ejmech.2025.117961.
  3. A. Armstrong, F. Coburn, Y. Nsereko, and O. Al Musaimi*, “ Peptide-Drug Conjugates: A New Hope for Cancer,” Journal of Peptide Science 31, no. 8 (2025): e70040, https://doi.org/10.1002/psc.70040
  4. Appleby, S.*; Al Musaimi, O.* Socioeconomic Deprivation and Opioid Consumption: An Analysis Across England. Int. J. Environ. Res. Public Health 2025, 22, 750. https://doi.org/10.3390/ijerph22050750
  5. Al Musaimi, O.*; AlShaer, D.; de la Torre, B.G.; Albericio, F.* 2024 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals 2025, 18, 291. https://doi.org/10.3390/ph18030291
  6. Al Musaimi O. FDA-Approved Antibacterials and Echinocandins. Antibiotics 2025, 14, 166.
  7. Diab A, Dickerson H, Al Musaimi O. Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis. Pharmaceuticals 2025, 18(1), 70.
  8. Al Musaimi, O., Tomkins, J., Barry S. M., Basso, A., kou, X., Zhang, C., Serban, S. Towards green, scalable peptide synthesis: leveraging DEG-crosslinked polystyrene resins to overcome hydrophobicity challenges. RSC Advances. Accepted.
  9. Mohammed, A.A., AlShaer, D. & Al Musaimi, O. Oligonucleotides: evolution and innovation. Med Chem Res 33, 2204–2220 (2024). https://doi.org/10.1007/s00044-024-03352-7.
  10. Al Musaimi, O.* Lasso Peptides Realm: Insights and Applications. Peptides. 2024, 10.1016/j.peptides.2024, 182, 171317.
  11. Dickerson, H., Diab, A., and Al Musaimi, O.* Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer: Current Use and Future Prospects. Int. J. Mol. Sci. 2024, 25,(18): p. 10008. 10.3390/ijms251810008
  12. Al Musaimi, O.* Unlocking the Potential of Retro-Inverso (RI) Peptides as Future Drug Candidates. Int. J. Pept. Res. Ther. 2024, 30,(5): p. 56. 10.1007/s10989-024-10639-1
  13. Al Musaimi, O., Ng, K.W., Gavva, V., Mercado-Valenzo, O.M., Haroon, H.B., and Williams, D.R. Elastin-Derived Peptide-Based Hydrogels as a Potential Drug Delivery System. Gels 2024, 10,(8): p. 531. 10.3390/gels10080531
  14. Al Musaimi, O., and Da’san M. M. Jaradat. Advances in Therapeutic Peptides Separation and Purification. Separations. 2024. 10.3390/separations11080233
  15. Al Musaimi, O.* FDA’s stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond. J. Pept. Sci. 2024: p. e3627. 10.1002/psc.3627
  16. Al Musaimi, O.* Peptide Therapeutics: Unveiling the Potential against Cancer—A Journey through 1989. Cancers, 2024. 16, DOI: 10.3390/cancers16051032.
  17. Al Musaimi, O.* Exploring FDA-Approved Frontiers: Insights into Natural and Engineered Peptide Analogues in the GLP-1, GIP, GHRH, CCK, ACTH, and & α-MSH Realms. Biomolecules, 2024. 14, DOI: 10.3390/biom14030264
  18. Al Shaer, D., Al Musaimi, O., Albericio, F., and de la Torre, B.G. 2023 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals, 2024. 17, 10.3390/ph17020243.
  19. Zulfiqar, N., Nadeem, R., and Al Musaimi, O. Photocatalytic Degradation of Antibiotics via Exploitation of a Magnetic Nanocomposite: A Green Nanotechnology Approach toward Drug-Contaminated Wastewater Reclamation. ACS Omega 2024. 9,(7): p. 7986-8004. 10.1021/acsomega.3c08116
  20. Gavva, V.; Al Musaimi, O.; Bent, C.; Williams, D. R. Determining the Hydrophobicity Index of Protected Amino Acids and Common Protecting Groups. Separations 2023. 10(8), 456. 10.3390/separations10080456
  21. Al Musaimi, O.; Al Shaer, D.; de la Torre, B.G.; Albericio, F. 2022 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals. Harvest. Pharmaceuticals 2023. 16(3), 336. 10.3390/ph16030336
  22. Al Musaimi, O., Mercado-Valenzo, O.M., and Williams, D.R. Factors Influencing the Prediction Accuracy of Model Peptides in Reversed-Phase Liquid Chromatography. Separations 2023, 10,(2): p. 81. 10.3390/separations10020081
  23. Al Musaimi, O., L. Lombardi, D.R. Williams, and F. Albericio. Strategies for Improving Peptide Stability and Delivery. Pharmaceuticals 2022, 15,(10): p. 1283. 10.3390/ph15101283
  24. Al Musaimi, O., Gavva, V., and Williams, D.R. Greener Cleavage of Protected Peptide Fragments from Sieber Amide Resin. ChemistryOpen 2022, 11,(12): p. e202200236. 10.1002/open.202200236
  25. Al Musaimi, O., Valenzo, O.M.M., and Williams, D.R. Prediction of peptides retention behavior in reversed-phase liquid chromatography based on their hydrophobicity. Journal of Separation Science 2023, 46,(2): p. 2200743. 10.1002/jssc.202200743.
  26. Al Musaimi, O., Morse, S.V., Lombardi, L., Serban, S., Basso, A., and Williams, D.R. Successful synthesis of a glial-specific blood–brain barrier shuttle peptide following a fragment condensation approach on a solid-phase resin. J. Pept. Sci. 2022: p. e3448. 10.1002/psc.3448
  27. Jaradat, D. M. M.; Al Musaimi, O.; Albericio, F. Advances in Solid-Phase Peptide Synthesis in Aqueous Media (ASPPS). Green Chem. 2022, 24, 6360-6372, 10.1039/D2GC02319A.
  28. Al Shaer, D.; Al Musaimi, O.; Albericio, F.; de la Torre, B.G. 2021 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals 2022, 15, 222. https://doi.org/10.3390/ph15020222
  29. Al Musaimi, O.; Al Shaer, D.; de la Torre, B. G.; Albericio, F. Green Circular Economy Applied to peptide Synthesis. Chimica Oggi/Chemistry Today 2021, 39, 42-45. https://www.teknoscienze.com/tks_article/green-circular-economy-applied-to-peptide-synthesis/
  30. Al Musaimi, O.; Al Shaer, D.; Albericio, F.; de la Torre, B. G. 2020 FDA TIDES (Peptides & Oligonucleotides) Harvest. Pharmaceuticals (Basel) 2021, 14, 145, 10.3390/ph14020145
  31. Al Musaimi, O.; Wisdom, R.; Talbiersky, P.; De La Torre, B. G.; Albericio, F. Propylphosphonic Anhydride (T3P®) as Coupling Reagent for Solid-Phase Peptide Synthesis. ChemistrySelect. 2021, 6, 1-10, 10.1002/slct.202100123. (with journal cover).
  32. Al Shaer, D.; Al Musaimi, O.; de la Torre, B. G.; Albericio, F. Hydroxamate Siderophores: Natural Occurrence, Chemical Synthesis, Iron Binding Affinity and Use as Trojan Horses Against Pathogens. Eur. J. Med. Chem. 2020, 208, 112791, 10.1016/j.ejmech.2020.11279.
  33. Al Musaimi, O.; Summer, B. D.; Alhassan, M.; de la Torre, B. G.; Albericio, F.; Serban, S.; Basso, A. Analytical methodologies to assure successful peptide synthesis when utilizing polystyrene/DVB resins. Chimica Oggi/Chemistry Today 2020, 38, 48-51. https://www.teknoscienze.com/tks_article/analytical-methodologies-to-assure-successful-peptide-synthesis-when-utilizing-polystyrene-dvb-resins/
  34. Alhassan, M., Al Musaimi, O., Collins, J.M., Albericio, F., and de la Torre, B.G. Cleaving protected peptides from 2-chlorotrityl chloride resin. Moving away from dichloromethane. Green Chem. 2020, 22,(9): p. 2840-2845. 10.1039/D0GC00834F.
  35. Al Shaer, D.; Al Musaimi, O.; Albericio, F.; de la Torre, B. G. 2019 FDA TIDES (Peptides & Oligonucleotides) Harvest. Pharmaceuticals (Basel) 2020, 13, 40, 10.3390/ph13030040.
  36. Al Musaimi, O.; Summer, B. D.; Basso, A.; de la Torre, B. G.; Albericio, F.; Serban, S. Combining Solid Phase Synthesis and Chromatographic Purification for Efficient Peptide Manufacture. Chimica Oggi/Chemistry Today 2020, 38, 18-21. https://www.teknoscienze.com/tks_article/combining-solid-phase-synthesis-and-chromatographic-purification-for-efficient-peptide-manufacture/
  37. Al Musaimi, O.; de la Torre, B.G.; Albericio, F. Greening Fmoc/tBu Solid-Phase Peptide Synthesis. Green Chem. 2020, 22, 996-1018, 10.1039/C9GC03982A.
  38. Al Musaimi, O.; Basso, A.; de la Torre, B.G.; Albericio, F. Calculating resin functionalization in solid-phase peptide synthesis using a standardized method based on fmoc determination. ACS Combinatorial Science 2019, 21, 717-721, 10.1021/acscombsci.9b00154
  39. Al Musaimi, O.; El-Faham, A.; Basso, A.; de la Torre, B.G.; Albericio, F. γ-valerolactone (gvl): An eco-friendly anchoring solvent for solid-phase peptide synthesis. Tetrahedron Lett. 2019, 60. 10.1016/j.tetlet.2019.151058
  40. Al Musaimi, O.; El-Faham, A.; Almarhoon, Z.; Basso, A.; de la Torre, B.G.; Albericio, F. Bypassing osmotic shock dilemma in a polystyrene resin using the green solvent cyclopentyl methyl ether (cpme): A morphological perspective. Polymers (Basel) 2019, 11. 10.3390/polym11050874
  41. Al Musaimi, O.; Serban, S.; Jad, Y.E.; Ma, Z.; Kumar, A.; Ji, C.; de la Torre, B.G.; Basso, A.; Albericio, F. Jetting manufacturing of resins for solid-phase peptide synthesis. Chimica Oggi/Chemistry Today 2019, 37, 20-23. https://www.teknoscienze.com/tks_article/jetting-manufacturing-of-resins-for-solid-phase-peptide-synthesis/
  42. Al Musaimi, O.; Serban, S.; Jad, Y.E.; Ma, Z.; Kumar, A.; Ji, C.; de la Torre, B.G.; East, N.R.; Basso, A.; Albericio, F. New manufacturing process to produce highly uniform resins with excellent performances in solid phase peptide synthesis. Chimica Oggi/Chemistry Today 2019, 37, 8-10. https://www.teknoscienze.com/tks_article/new-manufacturing-process-to-produce-highly-uniform-resins-with-excellent-performances-in-solid-phase-peptide-synthesis/
  43. Al Shaer, D.; Al Musaimi, O.; Albericio, F.; de la Torre, B.G. 2018 FDA TIDES Harvest. Pharmaceuticals (Basel) 2019, 12, 1-6. 10.3390/ph12020052
  44. Musaimi, O..; Abu-Nawwas, A.H.; Shaer, D.A.; Khaleel, N.Y.; Fawzi, M. Influence of age, gender, smoking, diabetes, thyroid and cardiac dysfunctions on cystatin c biomarker. Medicina de Familia. SEMERGEN 2018. 10.1016/j.semerg.2018.07.005
  45. Al Musaimi, O.; Jad, Y.E.; Kumar, A.; El-Faham, A.; Collins, J.M.; Basso, A.; de la Torre, B.G.; Albericio, F. Greening the solid-phase peptide synthesis process. 2‑MeTHF for the incorporation of the first amino acid and precipitation of peptides after global deprotection. Org. Process Res. Dev. 2018, 22, 1809-1816. 10.1021/acs.oprd.8b00335
  46. Al Musaimi, O.; Al Shaer, D.; de la Torre, B.G.; Albericio, F. 2017 FDA peptide Harvest. Pharmaceuticals (Basel) 2018, 11. 10.3390/ph11020042
  47. Al Musaimi, O.; Jad, Y.E.; Kumar, A.; Collins, J.M.; Basso, A.; de la Torre, B.G.; Albericio, F. Investigating green ethers for the precipitation of peptides after global deprotection in solid-phase peptide synthesis. Curr. Opin. Green Sustain. Chem. 2018, 11, 99-103. 10.1016/j.cogsc.2018.06.017
  48. Al Musaimi, O.; Abu‐Nawwas, A.A.H.; AlShaer, D.M.; Khaleel, N.Y. New hplc method for determination of cystatin c biomarker in human blood. Eur. J. Chem. 2017, 8, 378-383. 10.5155/eurjchem.8.4.378-383.1658
  49. Al Musaimi, O.*; Fayyad, M.K.; Mishal, A.K. Novel liquid chromatographic determination of cystatin c in human urine. J Chromatogr B Analyt Technol Biomed Life Sci 2009, 877, 747-750. 10.1016/j.jchromb.2009.02.009