Publications

Patents

  • Al Musaimi, O.; Williams, D. R. Methods of Chemical Synthesis of Oligonucleotides; I.P. Office, Ed.; Imperial College Innovations Limited: London, 2415649.9, UK, 2024
  • Al Musaimi, O.; Williams, D. R. Methods of Chemical Synthesis of Peptides; I.P. Office, Ed.; Imperial College Innovations Limited: London, CT/EP2024/067557, UK, 2024
  • Al Musaimi, O.; Williams, D. R. Solution Phase Peptide Synthesis; I.P. Office, Ed.; Imperial College Innovations Limited: London, GB2409647.1, UK, 2024.
  • Al Musaimi, O.; Williams, D. R. Methods of Chemical Synthesis of Peptides; I.P. Office, Ed.; Imperial College Innovations Limited: London, GB2312735.0, UK, 2023.

Articles

  1. Al Musaimi, O., Tomkins, J., Barry S. M., Basso, A., kou, X., Zhang, C., Serban, S. Towards green, scalable peptide synthesis: leveraging DEG-crosslinked polystyrene resins to overcome hydrophobicity challenges. RSC Advances. Accepted.
  2. Mohammed, A.A., AlShaer, D. & Al Musaimi, O. Oligonucleotides: evolution and innovation. Med Chem Res 33, 2204–2220 (2024). https://doi.org/10.1007/s00044-024-03352-7.
  3. Al Musaimi, O.* Lasso Peptides Realm: Insights and Applications. Peptides. 2024, 10.1016/j.peptides.2024, 182, 171317.
  4. Dickerson, H., Diab, A., and Al Musaimi, O.* Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer: Current Use and Future Prospects. Int. J. Mol. Sci. 2024, 25,(18): p. 10008. 10.3390/ijms251810008
  5. Al Musaimi, O.* Unlocking the Potential of Retro-Inverso (RI) Peptides as Future Drug Candidates. Int. J. Pept. Res. Ther. 2024, 30,(5): p. 56. 10.1007/s10989-024-10639-1
  6. Al Musaimi, O., Ng, K.W., Gavva, V., Mercado-Valenzo, O.M., Haroon, H.B., and Williams, D.R. Elastin-Derived Peptide-Based Hydrogels as a Potential Drug Delivery System. Gels 2024, 10,(8): p. 531. 10.3390/gels10080531
  7. Al Musaimi, O., and Da’san M. M. Jaradat. Advances in Therapeutic Peptides Separation and Purification. Separations. 2024. 10.3390/separations11080233
  8. Al Musaimi, O.* FDA’s stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond. J. Pept. Sci. 2024: p. e3627. 10.1002/psc.3627
  9. Al Musaimi, O.* Peptide Therapeutics: Unveiling the Potential against Cancer—A Journey through 1989. Cancers, 2024. 16, DOI: 10.3390/cancers16051032.
  10. Al Musaimi, O.* Exploring FDA-Approved Frontiers: Insights into Natural and Engineered Peptide Analogues in the GLP-1, GIP, GHRH, CCK, ACTH, and & α-MSH Realms. Biomolecules, 2024. 14, DOI: 10.3390/biom14030264
  11. Al Shaer, D., Al Musaimi, O., Albericio, F., and de la Torre, B.G. 2023 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals, 2024. 17, 10.3390/ph17020243.
  12. Zulfiqar, N., Nadeem, R., and Al Musaimi, O. Photocatalytic Degradation of Antibiotics via Exploitation of a Magnetic Nanocomposite: A Green Nanotechnology Approach toward Drug-Contaminated Wastewater Reclamation. ACS Omega 2024. 9,(7): p. 7986-8004. 10.1021/acsomega.3c08116
  13. Gavva, V.; Al Musaimi, O.; Bent, C.; Williams, D. R. Determining the Hydrophobicity Index of Protected Amino Acids and Common Protecting Groups. Separations 2023. 10(8), 456. 10.3390/separations10080456
  14. Al Musaimi, O.; Al Shaer, D.; de la Torre, B.G.; Albericio, F. 2022 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals. Harvest. Pharmaceuticals 2023. 16(3), 336. 10.3390/ph16030336
  15. Al Musaimi, O., Mercado-Valenzo, O.M., and Williams, D.R. Factors Influencing the Prediction Accuracy of Model Peptides in Reversed-Phase Liquid Chromatography. Separations 2023, 10,(2): p. 81. 10.3390/separations10020081
  16. Al Musaimi, O., L. Lombardi, D.R. Williams, and F. Albericio. Strategies for Improving Peptide Stability and Delivery. Pharmaceuticals 2022, 15,(10): p. 1283. 10.3390/ph15101283
  17. Al Musaimi, O., Gavva, V., and Williams, D.R. Greener Cleavage of Protected Peptide Fragments from Sieber Amide Resin. ChemistryOpen 2022, 11,(12): p. e202200236. 10.1002/open.202200236
  18. Al Musaimi, O., Valenzo, O.M.M., and Williams, D.R. Prediction of peptides retention behavior in reversed-phase liquid chromatography based on their hydrophobicity. Journal of Separation Science 2023, 46,(2): p. 2200743. 10.1002/jssc.202200743.
  19. Al Musaimi, O., Morse, S.V., Lombardi, L., Serban, S., Basso, A., and Williams, D.R. Successful synthesis of a glial-specific blood–brain barrier shuttle peptide following a fragment condensation approach on a solid-phase resin. J. Pept. Sci. 2022: p. e3448. 10.1002/psc.3448
  20. Jaradat, D. M. M.; Al Musaimi, O.; Albericio, F. Advances in Solid-Phase Peptide Synthesis in Aqueous Media (ASPPS). Green Chem. 2022, 24, 6360-6372, 10.1039/D2GC02319A.
  21. Al Shaer, D.; Al Musaimi, O.; Albericio, F.; de la Torre, B.G. 2021 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals 2022, 15, 222. https://doi.org/10.3390/ph15020222
  22. Al Musaimi, O.; Al Shaer, D.; de la Torre, B. G.; Albericio, F. Green Circular Economy Applied to peptide Synthesis. Chimica Oggi/Chemistry Today 2021, 39, 42-45. https://www.teknoscienze.com/tks_article/green-circular-economy-applied-to-peptide-synthesis/
  23. Al Musaimi, O.; Al Shaer, D.; Albericio, F.; de la Torre, B. G. 2020 FDA TIDES (Peptides & Oligonucleotides) Harvest. Pharmaceuticals (Basel) 2021, 14, 145, 10.3390/ph14020145
  24. Al Musaimi, O.; Wisdom, R.; Talbiersky, P.; De La Torre, B. G.; Albericio, F. Propylphosphonic Anhydride (T3P®) as Coupling Reagent for Solid-Phase Peptide Synthesis. ChemistrySelect. 2021, 6, 1-10, 10.1002/slct.202100123. (with journal cover).
  25. Al Shaer, D.; Al Musaimi, O.; de la Torre, B. G.; Albericio, F. Hydroxamate Siderophores: Natural Occurrence, Chemical Synthesis, Iron Binding Affinity and Use as Trojan Horses Against Pathogens. Eur. J. Med. Chem. 2020, 208, 112791, 10.1016/j.ejmech.2020.11279.
  26. Al Musaimi, O.; Summer, B. D.; Alhassan, M.; de la Torre, B. G.; Albericio, F.; Serban, S.; Basso, A. Analytical methodologies to assure successful peptide synthesis when utilizing polystyrene/DVB resins. Chimica Oggi/Chemistry Today 2020, 38, 48-51. https://www.teknoscienze.com/tks_article/analytical-methodologies-to-assure-successful-peptide-synthesis-when-utilizing-polystyrene-dvb-resins/
  27. Alhassan, M., Al Musaimi, O., Collins, J.M., Albericio, F., and de la Torre, B.G. Cleaving protected peptides from 2-chlorotrityl chloride resin. Moving away from dichloromethane. Green Chem. 2020, 22,(9): p. 2840-2845. 10.1039/D0GC00834F.
  28. Al Shaer, D.; Al Musaimi, O.; Albericio, F.; de la Torre, B. G. 2019 FDA TIDES (Peptides & Oligonucleotides) Harvest. Pharmaceuticals (Basel) 2020, 13, 40, 10.3390/ph13030040.
  29. Al Musaimi, O.; Summer, B. D.; Basso, A.; de la Torre, B. G.; Albericio, F.; Serban, S. Combining Solid Phase Synthesis and Chromatographic Purification for Efficient Peptide Manufacture. Chimica Oggi/Chemistry Today 2020, 38, 18-21. https://www.teknoscienze.com/tks_article/combining-solid-phase-synthesis-and-chromatographic-purification-for-efficient-peptide-manufacture/
  30. Al Musaimi, O.; de la Torre, B.G.; Albericio, F. Greening Fmoc/tBu Solid-Phase Peptide Synthesis. Green Chem. 2020, 22, 996-1018, 10.1039/C9GC03982A.
  31. Al Musaimi, O.; Basso, A.; de la Torre, B.G.; Albericio, F. Calculating resin functionalization in solid-phase peptide synthesis using a standardized method based on fmoc determination. ACS Combinatorial Science 2019, 21, 717-721, 10.1021/acscombsci.9b00154
  32. Al Musaimi, O.; El-Faham, A.; Basso, A.; de la Torre, B.G.; Albericio, F. γ-valerolactone (gvl): An eco-friendly anchoring solvent for solid-phase peptide synthesis. Tetrahedron Lett. 2019, 60. 10.1016/j.tetlet.2019.151058
  33. Al Musaimi, O.; El-Faham, A.; Almarhoon, Z.; Basso, A.; de la Torre, B.G.; Albericio, F. Bypassing osmotic shock dilemma in a polystyrene resin using the green solvent cyclopentyl methyl ether (cpme): A morphological perspective. Polymers (Basel) 2019, 11. 10.3390/polym11050874
  34. Al Musaimi, O.; Serban, S.; Jad, Y.E.; Ma, Z.; Kumar, A.; Ji, C.; de la Torre, B.G.; Basso, A.; Albericio, F. Jetting manufacturing of resins for solid-phase peptide synthesis. Chimica Oggi/Chemistry Today 2019, 37, 20-23. https://www.teknoscienze.com/tks_article/jetting-manufacturing-of-resins-for-solid-phase-peptide-synthesis/
  35. Al Musaimi, O.; Serban, S.; Jad, Y.E.; Ma, Z.; Kumar, A.; Ji, C.; de la Torre, B.G.; East, N.R.; Basso, A.; Albericio, F. New manufacturing process to produce highly uniform resins with excellent performances in solid phase peptide synthesis. Chimica Oggi/Chemistry Today 2019, 37, 8-10. https://www.teknoscienze.com/tks_article/new-manufacturing-process-to-produce-highly-uniform-resins-with-excellent-performances-in-solid-phase-peptide-synthesis/
  36. Al Shaer, D.; Al Musaimi, O.; Albericio, F.; de la Torre, B.G. 2018 FDA TIDES Harvest. Pharmaceuticals (Basel) 2019, 12, 1-6. 10.3390/ph12020052
  37. Musaimi, O..; Abu-Nawwas, A.H.; Shaer, D.A.; Khaleel, N.Y.; Fawzi, M. Influence of age, gender, smoking, diabetes, thyroid and cardiac dysfunctions on cystatin c biomarker. Medicina de Familia. SEMERGEN 2018. 10.1016/j.semerg.2018.07.005
  38. Al Musaimi, O.; Jad, Y.E.; Kumar, A.; El-Faham, A.; Collins, J.M.; Basso, A.; de la Torre, B.G.; Albericio, F. Greening the solid-phase peptide synthesis process. 2‑MeTHF for the incorporation of the first amino acid and precipitation of peptides after global deprotection. Org. Process Res. Dev. 2018, 22, 1809-1816. 10.1021/acs.oprd.8b00335
  39. Al Musaimi, O.; Al Shaer, D.; de la Torre, B.G.; Albericio, F. 2017 FDA peptide Harvest. Pharmaceuticals (Basel) 2018, 11. 10.3390/ph11020042
  40. Al Musaimi, O.; Jad, Y.E.; Kumar, A.; Collins, J.M.; Basso, A.; de la Torre, B.G.; Albericio, F. Investigating green ethers for the precipitation of peptides after global deprotection in solid-phase peptide synthesis. Curr. Opin. Green Sustain. Chem. 2018, 11, 99-103. 10.1016/j.cogsc.2018.06.017
  41. Al Musaimi, O.; Abu‐Nawwas, A.A.H.; AlShaer, D.M.; Khaleel, N.Y. New hplc method for determination of cystatin c biomarker in human blood. Eur. J. Chem. 2017, 8, 378-383. 10.5155/eurjchem.8.4.378-383.1658
  42. Al Musaimi, O.*; Fayyad, M.K.; Mishal, A.K. Novel liquid chromatographic determination of cystatin c in human urine. J Chromatogr B Analyt Technol Biomed Life Sci 2009, 877, 747-750. 10.1016/j.jchromb.2009.02.009