{"id":90,"date":"2024-12-18T20:57:37","date_gmt":"2024-12-18T20:57:37","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/othmanalmusaimi\/?page_id=90"},"modified":"2025-08-20T12:48:46","modified_gmt":"2025-08-20T11:48:46","slug":"publications","status":"publish","type":"page","link":"https:\/\/blogs.ncl.ac.uk\/othmanalmusaimi\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>Patents<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Al Musaimi, O.; Williams, D. R. Solution Phase Peptide Synthesis; I.P. Office, Ed.; Imperial College Innovations Limited: London, PCT\/GB2025\/051451, UK, 2025.<\/li>\n\n\n\n<li>Al Musaimi, O.; Williams, D. R. Methods of Chemical Synthesis of Oligonucleotides; I.P. Office, Ed.; Imperial College Innovations Limited: London, 2415649.9, UK, 2024<\/li>\n\n\n\n<li>Al Musaimi, O.; Williams, D. R. Methods of Chemical Synthesis of Peptides; I.P. Office, Ed.; Imperial College Innovations Limited: London, UK, WO2024261319A1, 07\/12\/2024<\/li>\n\n\n\n<li>Al Musaimi, O.; Williams, D. R. Solution Phase Peptide Synthesis; I.P. Office, Ed.; Imperial College Innovations Limited: London, GB2409647.1, UK, 2024.<\/li>\n\n\n\n<li>Al Musaimi, O.; Williams, D. R. Methods of Chemical Synthesis of Peptides; I.P. Office, Ed.; Imperial College Innovations Limited: London, GB2312735.0, UK, 2023.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Articles<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Nsereko, Y., Armstrong, A., Coburn, F., and <strong>Al Musaimi, O.*<\/strong> Innovative Peptide Therapeutics in the Pipeline: Transforming Cancer Detection and Treatment. Int. J. Mol. Sci., 2025. 26, DOI: 10.3390\/ijms26146815.<\/li>\n\n\n\n<li>Coburn, F., Nsereko, Y., Armstrong, A., and <strong>Al Musaimi, O<\/strong>.<strong>*<\/strong> Peptide inhibitors: Breaking cancer code. Eur. J. Med. Chem. 2025, 297: p. 117961. 10.1016\/j.ejmech.2025.117961.<\/li>\n\n\n\n<li>A. Armstrong,\u00a0F. Coburn,\u00a0Y. Nsereko, and\u00a0<strong>O. Al\u00a0Musaimi*<\/strong>, \u201c\u00a0Peptide-Drug Conjugates: A New Hope for Cancer,\u201d\u00a0Journal of Peptide Science\u00a031, no.\u00a08\u00a0(2025): e70040,\u00a0<a href=\"https:\/\/doi.org\/10.1002\/psc.70040\">https:\/\/doi.org\/10.1002\/psc.70040<\/a><\/li>\n\n\n\n<li>Appleby, S.*; Al Musaimi, O.* Socioeconomic Deprivation and Opioid Consumption: An Analysis Across England. Int. J. Environ. Res. Public Health 2025, 22, 750. https:\/\/doi.org\/10.3390\/ijerph22050750<\/li>\n\n\n\n<li>Al Musaimi, O.*; AlShaer, D.; de la Torre, B.G.; Albericio, F.* 2024 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals 2025, 18, 291. https:\/\/doi.org\/10.3390\/ph18030291<\/li>\n\n\n\n<li>Al Musaimi O. FDA-Approved Antibacterials and Echinocandins. Antibiotics 2025, 14, 166.<\/li>\n\n\n\n<li>Diab A, Dickerson H, Al Musaimi O. Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis. Pharmaceuticals 2025, 18(1), 70.<\/li>\n\n\n\n<li>Al Musaimi, O., Tomkins, J., Barry S. M., Basso, A., kou, X., Zhang, C., Serban, S. Towards green, scalable peptide synthesis: leveraging DEG-crosslinked polystyrene resins to overcome hydrophobicity challenges. RSC Advances. Accepted.<\/li>\n\n\n\n<li>Mohammed, A.A., AlShaer, D. &amp; Al Musaimi, O. Oligonucleotides: evolution and innovation.&nbsp;<em>Med Chem Res<\/em>&nbsp;<strong>33<\/strong>, 2204\u20132220 (2024). https:\/\/doi.org\/10.1007\/s00044-024-03352-7.<\/li>\n\n\n\n<li>Al Musaimi, O.* Lasso Peptides Realm: Insights and Applications. Peptides. 2024, 10.1016\/j.peptides.2024, 182, 171317. <\/li>\n\n\n\n<li>Dickerson, H., Diab, A., and Al Musaimi, O.* Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer: Current Use and Future Prospects. Int. J. Mol. Sci. 2024, 25,(18): p. 10008. 10.3390\/ijms251810008 <\/li>\n\n\n\n<li>Al Musaimi, O.* Unlocking the Potential of Retro-Inverso (RI) Peptides as Future Drug Candidates. Int. J. Pept. Res. Ther. 2024, 30,(5): p. 56. 10.1007\/s10989-024-10639-1 <\/li>\n\n\n\n<li>Al Musaimi, O.<em>, Ng, K.W., Gavva, V., Mercado-Valenzo, O.M., Haroon, H.B., and Williams, D.R. Elastin-Derived Peptide-Based Hydrogels as a Potential Drug Delivery System. Gels 2024, 10,(8): p. 531. 10.3390\/gels10080531 <\/em><\/li>\n\n\n\n<li><em>Al Musaimi, O.<\/em>, and Da\u2019san M. M. Jaradat. Advances in Therapeutic Peptides Separation and Purification. Separations. 2024. 10.3390\/separations11080233 <\/li>\n\n\n\n<li>Al Musaimi, O.* FDA&#8217;s stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond. J. Pept. Sci. 2024: p. e3627. 10.1002\/psc.3627 <\/li>\n\n\n\n<li>Al Musaimi, O.* Peptide Therapeutics: Unveiling the Potential against Cancer\u2014A Journey through 1989. Cancers, 2024. 16, DOI: 10.3390\/cancers16051032. <\/li>\n\n\n\n<li>Al Musaimi, O.* Exploring FDA-Approved Frontiers: Insights into Natural and Engineered Peptide Analogues in the GLP-1, GIP, GHRH, CCK, ACTH, and &amp; \u03b1-MSH Realms. Biomolecules, 2024. 14, DOI: 10.3390\/biom14030264 <\/li>\n\n\n\n<li>Al Shaer, D., Al Musaimi, O.<em>, Albericio, F., and de la Torre, B.G. 2023 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals, 2024. 17, 10.3390\/ph17020243. <\/em><\/li>\n\n\n\n<li><em>Zulfiqar, N., Nadeem, R., and Al Musaimi, O. Photocatalytic Degradation of Antibiotics via Exploitation of a Magnetic Nanocomposite: A Green Nanotechnology Approach toward Drug-Contaminated Wastewater Reclamation. ACS Omega 2024. 9,(7): p. 7986-8004. 10.1021\/acsomega.3c08116 <\/em><\/li>\n\n\n\n<li><em>Gavva, V.; Al Musaimi, O.<\/em>; Bent, C.; Williams, D. R. Determining the Hydrophobicity Index of Protected Amino Acids and Common Protecting Groups. Separations 2023. 10(8), 456. 10.3390\/separations10080456 <\/li>\n\n\n\n<li>Al Musaimi, O.<em>; Al Shaer, D.; de la Torre, B.G.; Albericio, F. 2022 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals. Harvest. Pharmaceuticals 2023. 16(3), 336. 10.3390\/ph16030336 <\/em><\/li>\n\n\n\n<li><em>Al Musaimi, O.<\/em>, Mercado-Valenzo, O.M., and Williams, D.R. Factors Influencing the Prediction Accuracy of Model Peptides in Reversed-Phase Liquid Chromatography. Separations 2023, 10,(2): p. 81. 10.3390\/separations10020081 <\/li>\n\n\n\n<li>Al Musaimi, O.<em>, L. Lombardi, D.R. Williams, and F. Albericio. Strategies for Improving Peptide Stability and Delivery. Pharmaceuticals 2022, 15,(10): p. 1283. 10.3390\/ph15101283 <\/em><\/li>\n\n\n\n<li><em>Al Musaimi, O.<\/em>, Gavva, V., and Williams, D.R. Greener Cleavage of Protected Peptide Fragments from Sieber Amide Resin. ChemistryOpen 2022, 11,(12): p. e202200236. 10.1002\/open.202200236 <\/li>\n\n\n\n<li>Al Musaimi, O.<em>, Valenzo, O.M.M., and Williams, D.R. Prediction of peptides retention behavior in reversed-phase liquid chromatography based on their hydrophobicity. Journal of Separation Science 2023, 46,(2): p. 2200743. 10.1002\/jssc.202200743. <\/em><\/li>\n\n\n\n<li><em>Al Musaimi, O.<\/em>, Morse, S.V., Lombardi, L., Serban, S., Basso, A., and Williams, D.R. Successful synthesis of a glial-specific blood\u2013brain barrier shuttle peptide following a fragment condensation approach on a solid-phase resin. J. Pept. Sci. 2022: p. e3448. 10.1002\/psc.3448 <\/li>\n\n\n\n<li>Jaradat, D. M. M.; Al Musaimi, O.<em>; Albericio, F. Advances in Solid-Phase Peptide Synthesis in Aqueous Media (ASPPS). Green Chem. 2022, 24, 6360-6372, 10.1039\/D2GC02319A. <\/em><\/li>\n\n\n\n<li><em>Al Shaer, D.; Al Musaimi, O.; Albericio, F.; de la Torre, B.G. 2021 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals 2022, 15, 222. https:\/\/doi.org\/10.3390\/ph15020222 <\/em><\/li>\n\n\n\n<li><em>Al Musaimi, O.<\/em>; Al Shaer, D.; de la Torre, B. G.; Albericio, F. Green Circular Economy Applied to peptide Synthesis. Chimica Oggi\/Chemistry Today 2021, 39, 42-45. https:\/\/www.teknoscienze.com\/tks_article\/green-circular-economy-applied-to-peptide-synthesis\/ <\/li>\n\n\n\n<li>Al Musaimi, O.; Al Shaer, D.; Albericio, F.; de la Torre, B. G. 2020 FDA TIDES (Peptides &amp; Oligonucleotides) Harvest. Pharmaceuticals (Basel) 2021, 14, 145, 10.3390\/ph14020145 <\/li>\n\n\n\n<li>Al Musaimi, O.; Wisdom, R.; Talbiersky, P.; De La Torre, B. G.; Albericio, F. Propylphosphonic Anhydride (T3P\u00ae) as Coupling Reagent for Solid-Phase Peptide Synthesis. ChemistrySelect. 2021, 6, 1-10, 10.1002\/slct.202100123. (with journal cover). <\/li>\n\n\n\n<li>Al Shaer, D.; Al Musaimi, O.; de la Torre, B. G.; Albericio, F. Hydroxamate Siderophores: Natural Occurrence, Chemical Synthesis, Iron Binding Affinity and Use as Trojan Horses Against Pathogens. Eur. J. Med. Chem. 2020, 208, 112791, 10.1016\/j.ejmech.2020.11279. <\/li>\n\n\n\n<li>Al Musaimi, O.; Summer, B. D.; Alhassan, M.; de la Torre, B. G.; Albericio, F.; Serban, S.; Basso, A. Analytical methodologies to assure successful peptide synthesis when utilizing polystyrene\/DVB resins. Chimica Oggi\/Chemistry Today 2020, 38, 48-51. https:\/\/www.teknoscienze.com\/tks_article\/analytical-methodologies-to-assure-successful-peptide-synthesis-when-utilizing-polystyrene-dvb-resins\/ <\/li>\n\n\n\n<li>Alhassan, M., Al Musaimi, O., Collins, J.M., Albericio, F., and de la Torre, B.G. Cleaving protected peptides from 2-chlorotrityl chloride resin. Moving away from dichloromethane. Green Chem. 2020, 22,(9): p. 2840-2845. 10.1039\/D0GC00834F. <\/li>\n\n\n\n<li>Al Shaer, D.; Al Musaimi, O.; Albericio, F.; de la Torre, B. G. 2019 FDA TIDES (Peptides &amp; Oligonucleotides) Harvest. Pharmaceuticals (Basel) 2020, 13, 40, 10.3390\/ph13030040. <\/li>\n\n\n\n<li>Al Musaimi, O.; Summer, B. D.; Basso, A.; de la Torre, B. G.; Albericio, F.; Serban, S. Combining Solid Phase Synthesis and Chromatographic Purification for Efficient Peptide Manufacture. Chimica Oggi\/Chemistry Today 2020, 38, 18-21. https:\/\/www.teknoscienze.com\/tks_article\/combining-solid-phase-synthesis-and-chromatographic-purification-for-efficient-peptide-manufacture\/ <\/li>\n\n\n\n<li>Al Musaimi, O.; de la Torre, B.G.; Albericio, F. Greening Fmoc\/tBu Solid-Phase Peptide Synthesis. Green Chem. 2020, 22, 996-1018, 10.1039\/C9GC03982A. <\/li>\n\n\n\n<li>Al Musaimi, O.; Basso, A.; de la Torre, B.G.; Albericio, F. Calculating resin functionalization in solid-phase peptide synthesis using a standardized method based on fmoc determination. ACS Combinatorial Science 2019, 21, 717-721, 10.1021\/acscombsci.9b00154 <\/li>\n\n\n\n<li>Al Musaimi, O.; El-Faham, A.; Basso, A.; de la Torre, B.G.; Albericio, F. \u03b3-valerolactone (gvl): An eco-friendly anchoring solvent for solid-phase peptide synthesis. Tetrahedron Lett. 2019, 60. 10.1016\/j.tetlet.2019.151058 <\/li>\n\n\n\n<li>Al Musaimi, O.; El-Faham, A.; Almarhoon, Z.; Basso, A.; de la Torre, B.G.; Albericio, F. Bypassing osmotic shock dilemma in a polystyrene resin using the green solvent cyclopentyl methyl ether (cpme): A morphological perspective. Polymers (Basel) 2019, 11. 10.3390\/polym11050874 <\/li>\n\n\n\n<li>Al Musaimi, O.; Serban, S.; Jad, Y.E.; Ma, Z.; Kumar, A.; Ji, C.; de la Torre, B.G.; Basso, A.; Albericio, F. Jetting manufacturing of resins for solid-phase peptide synthesis. Chimica Oggi\/Chemistry Today 2019, 37, 20-23. https:\/\/www.teknoscienze.com\/tks_article\/jetting-manufacturing-of-resins-for-solid-phase-peptide-synthesis\/ <\/li>\n\n\n\n<li>Al Musaimi, O.; Serban, S.; Jad, Y.E.; Ma, Z.; Kumar, A.; Ji, C.; de la Torre, B.G.; East, N.R.; Basso, A.; Albericio, F. New manufacturing process to produce highly uniform resins with excellent performances in solid phase peptide synthesis. Chimica Oggi\/Chemistry Today 2019, 37, 8-10. https:\/\/www.teknoscienze.com\/tks_article\/new-manufacturing-process-to-produce-highly-uniform-resins-with-excellent-performances-in-solid-phase-peptide-synthesis\/ <\/li>\n\n\n\n<li>Al Shaer, D.; Al Musaimi, O.; Albericio, F.; de la Torre, B.G. 2018 FDA TIDES Harvest. Pharmaceuticals (Basel) 2019, 12, 1-6. 10.3390\/ph12020052 <\/li>\n\n\n\n<li>Musaimi, O.<em>.; Abu-Nawwas, A.H.; Shaer, D.A.; Khaleel, N.Y.; Fawzi, M. Influence of age, gender, smoking, diabetes, thyroid and cardiac dysfunctions on cystatin c biomarker. Medicina de Familia. SEMERGEN 2018. 10.1016\/j.semerg.2018.07.005 <\/em><\/li>\n\n\n\n<li><em>Al Musaimi, O.; Jad, Y.E.; Kumar, A.; El-Faham, A.; Collins, J.M.; Basso, A.; de la Torre, B.G.; Albericio, F. Greening the solid-phase peptide synthesis process. 2\u2011MeTHF for the incorporation of the first amino acid and precipitation of peptides after global deprotection. Org. Process Res. Dev. 2018, 22, 1809-1816. 10.1021\/acs.oprd.8b00335 <\/em><\/li>\n\n\n\n<li><em>Al Musaimi, O.; Al Shaer, D.; de la Torre, B.G.; Albericio, F. 2017 FDA peptide Harvest. Pharmaceuticals (Basel) 2018, 11. 10.3390\/ph11020042 <\/em><\/li>\n\n\n\n<li><em>Al Musaimi, O.; Jad, Y.E.; Kumar, A.; Collins, J.M.; Basso, A.; de la Torre, B.G.; Albericio, F. Investigating green ethers for the precipitation of peptides after global deprotection in solid-phase peptide synthesis. Curr. Opin. Green Sustain. Chem. 2018, 11, 99-103. 10.1016\/j.cogsc.2018.06.017 <\/em><\/li>\n\n\n\n<li><em>Al Musaimi, O.<\/em>; Abu\u2010Nawwas, A.A.H.; AlShaer, D.M.; Khaleel, N.Y. New hplc method for determination of cystatin c biomarker in human blood. Eur. J. Chem. 2017, 8, 378-383. 10.5155\/eurjchem.8.4.378-383.1658 <\/li>\n\n\n\n<li>Al Musaimi, O.*; Fayyad, M.K.; Mishal, A.K. Novel liquid chromatographic determination of cystatin c in human urine. J Chromatogr B Analyt Technol Biomed Life Sci 2009, 877, 747-750. 10.1016\/j.jchromb.2009.02.009<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Patents Articles<\/p>\n","protected":false},"author":11737,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-90","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ncl.ac.uk\/othmanalmusaimi\/wp-json\/wp\/v2\/pages\/90","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ncl.ac.uk\/othmanalmusaimi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ncl.ac.uk\/othmanalmusaimi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/othmanalmusaimi\/wp-json\/wp\/v2\/users\/11737"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/othmanalmusaimi\/wp-json\/wp\/v2\/comments?post=90"}],"version-history":[{"count":16,"href":"https:\/\/blogs.ncl.ac.uk\/othmanalmusaimi\/wp-json\/wp\/v2\/pages\/90\/revisions"}],"predecessor-version":[{"id":350,"href":"https:\/\/blogs.ncl.ac.uk\/othmanalmusaimi\/wp-json\/wp\/v2\/pages\/90\/revisions\/350"}],"wp:attachment":[{"href":"https:\/\/blogs.ncl.ac.uk\/othmanalmusaimi\/wp-json\/wp\/v2\/media?parent=90"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}