{"id":26,"date":"2023-05-25T16:33:56","date_gmt":"2023-05-25T15:33:56","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/painresearch\/?page_id=26"},"modified":"2025-10-14T08:48:50","modified_gmt":"2025-10-14T07:48:50","slug":"research","status":"publish","type":"page","link":"https:\/\/blogs.ncl.ac.uk\/painresearch\/research\/","title":{"rendered":"Our Research"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Opportunities to be involved in research<\/h2>\n\n\n\n<p>The following studies are actively recruiting participants:<\/p>\n\n\n\n<p><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mitigate-trial\/\">MiTiGate Trial<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/elucidate\/\">Elucidate Study<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/face-pd-facial-pain-experience-in-parkinsons-disease\/\">FacE-PD study<\/a> <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left\">Current projects<\/h2>\n\n\n\n<div class=\"wp-block-query is-layout-flow wp-block-query-is-layout-flow\"><ul class=\"wp-block-post-template is-layout-flow wp-block-post-template-is-layout-flow\"><li class=\"wp-block-post post-283 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h3 class=\"wp-block-post-title has-larger-font-size\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mitigate-trial\/\" target=\"_self\" >MiTiGate trial<\/a><\/h3>\n\n<figure class=\"wp-block-post-featured-image wp-duotone-unset-1\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mitigate-trial\/\" target=\"_self\"  ><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"676\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-1200x676.jpeg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"MiTiGate trial\" style=\"object-fit:cover;\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-1200x676.jpeg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-300x169.jpeg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-1024x577.jpeg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-768x432.jpeg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-1536x865.jpeg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-2048x1153.jpeg 2048w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-1980x1115.jpeg 1980w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/a><\/figure>\n\n<div class=\"wp-block-post-excerpt has-small-font-size\"><p class=\"wp-block-post-excerpt__excerpt\">MiTiGate Trial: Managing chronic Myalgia Temporomandibular Disorder: a pragmatic randomised controlled trial of Botulinum toxin type A, lidocaine, and amitriptyline\/gabapentin, with internal pilot and cost-effectiveness analysis To learn more, visit the MiTiGate Trial website here: https:\/\/www.mitigatetrial.co.uk\/ To self-refer to the trial, please email nuth.mitigate@nhs.net Plain English summary of the study Temporomandibular disorders (TMD) affect the&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mitigate-trial\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-594 post type-post status-publish format-standard hentry category-research\">\n<h3 class=\"wp-block-post-title has-larger-font-size\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/oldpain2go\/\" target=\"_self\" >OldPain2Go<\/a><\/h3>\n\n\n\n<div class=\"wp-block-post-excerpt has-small-font-size\"><p class=\"wp-block-post-excerpt__excerpt\">A randomised pilot virtual feasibility study for a virtual randomized control trial of a novel brief intervention for people with low back pain.<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/oldpain2go\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-590 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h3 class=\"wp-block-post-title has-larger-font-size\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/extirpate-study-irreversible-pulpitis\/\" target=\"_self\" >EXTIRPATE study: Irreversible Pulpitis<\/a><\/h3>\n\n<figure class=\"wp-block-post-featured-image wp-duotone-unset-3\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/extirpate-study-irreversible-pulpitis\/\" target=\"_self\"  ><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"905\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Ex8_T2_R6_IPSI_x10_Macrophage_594_Neutr_488-FULL-ADJUST-COMBO-1200x905.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"EXTIRPATE study: Irreversible Pulpitis\" style=\"object-fit:cover;\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Ex8_T2_R6_IPSI_x10_Macrophage_594_Neutr_488-FULL-ADJUST-COMBO-1200x905.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Ex8_T2_R6_IPSI_x10_Macrophage_594_Neutr_488-FULL-ADJUST-COMBO-300x226.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Ex8_T2_R6_IPSI_x10_Macrophage_594_Neutr_488-FULL-ADJUST-COMBO-1024x772.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Ex8_T2_R6_IPSI_x10_Macrophage_594_Neutr_488-FULL-ADJUST-COMBO-768x579.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Ex8_T2_R6_IPSI_x10_Macrophage_594_Neutr_488-FULL-ADJUST-COMBO.jpg 1376w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/a><\/figure>\n\n<div class=\"wp-block-post-excerpt has-small-font-size\"><p class=\"wp-block-post-excerpt__excerpt\">Dental pain mechanisms remain poorly understood. Outcomes from current approaches to managing acute dental pain are suboptimal. EXTIRPATE focusses on developing a biological model to better understand peripheral and central pain mechanisms, explore the effect of current approaches on these mechanisms and investigate new treatment approaches.<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/extirpate-study-irreversible-pulpitis\/\">Read more<\/a><\/p><\/div>\n<\/li><\/ul><\/div>\n\n\n\n<p><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/category\/research\">See all research projects<\/a><\/p>\n\n\n\n<div style=\"height:56px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-center\">Our Research Themes<\/h1>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"726\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1024x726.jpg\" alt=\"\" class=\"wp-image-169 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1024x726.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-300x213.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-768x545.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1536x1089.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1200x851.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1980x1404.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Mechanisms and pathways of pain<\/h3>\n\n\n\n<p>Our work aims to understand how and why acute and persistent pain is experienced in painful conditions such as toothache, persistent facial pain, and neuropathic pain.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading has-text-align-right\">Pain therapeutics and clinical trials<\/h3>\n\n\n\n<p class=\"has-text-align-right\">In this research theme, our work explores new targets to treat painful conditions and assesses the efficacy, safety, and cost-effectiveness of clinical treatments.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1024x682.jpg\" alt=\"\" class=\"wp-image-171 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1024x682.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-300x200.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-768x512.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1536x1024.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1200x800.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1980x1320.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1024x682.jpg\" alt=\"\" class=\"wp-image-172 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1024x682.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-300x200.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-768x512.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1536x1024.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1200x800.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1980x1320.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Pain diagnostics<\/h3>\n\n\n\n<p>This work aims to improve on the current methods that clinicians have to diagnose pain conditions, and to measure and assess people&#8217;s experience of pain.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading has-text-align-right\">Applied pain research<\/h3>\n\n\n\n<p class=\"has-text-align-right\">Our research uses innovative clinical research, integrating multidisciplinary perspectives, to explore how best to help people who suffer from painful conditions. <\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"695\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1024x695.jpg\" alt=\"\" class=\"wp-image-167 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1024x695.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-300x204.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-768x521.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1536x1042.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1200x814.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1980x1343.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913.jpg 1999w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-center\">Our Collaborators<\/h1>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"684\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1024x684.jpg\" alt=\"\" class=\"wp-image-174 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1024x684.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-300x200.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-768x513.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1536x1025.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1200x801.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1980x1322.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">Academic collaborators<\/h5>\n\n\n\n<ul class=\"wp-block-list has-small-font-size\">\n<li>Osaka University, Japan<\/li>\n\n\n\n<li>University of Minnesota, MN, USA<\/li>\n\n\n\n<li>Aarhus University, Denmark<\/li>\n\n\n\n<li>University of Liverpool, UK<\/li>\n\n\n\n<li>University of Sheffield, UK<\/li>\n\n\n\n<li>University of Leeds, UK<\/li>\n\n\n\n<li>University of Manchester, UK<\/li>\n\n\n\n<li>Durham University, UK<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">Industrial collaborators<\/h5>\n\n\n\n<p>We work with several companies in the pharmaceutical and medical device sectors.<\/p>\n\n\n\n<ul class=\"wp-block-list has-small-font-size\">\n<li><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Opportunities to be involved in research The following studies are actively recruiting participants: MiTiGate Trial Elucidate Study FacE-PD study Current projects See all research projects Our Research Themes Mechanisms and pathways of pain Our work aims to understand how and why acute and persistent pain is experienced in painful conditions such as toothache, persistent facial [&hellip;]<\/p>\n","protected":false},"author":8160,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-26","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/26","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/users\/8160"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/comments?post=26"}],"version-history":[{"count":29,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/26\/revisions"}],"predecessor-version":[{"id":751,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/26\/revisions\/751"}],"wp:attachment":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/media?parent=26"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}