{"id":26,"date":"2023-05-25T16:33:56","date_gmt":"2023-05-25T15:33:56","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/painresearch\/?page_id=26"},"modified":"2025-10-14T08:48:50","modified_gmt":"2025-10-14T07:48:50","slug":"research","status":"publish","type":"page","link":"https:\/\/blogs.ncl.ac.uk\/painresearch\/research\/","title":{"rendered":"Our Research"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Opportunities to be involved in research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The following studies are actively recruiting participants:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mitigate-trial\/\">MiTiGate Trial<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/elucidate\/\">Elucidate Study<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/face-pd-facial-pain-experience-in-parkinsons-disease\/\">FacE-PD study<\/a> <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left\">Current projects<\/h2>\n\n\n\n<div class=\"wp-block-query is-layout-flow wp-block-query-is-layout-flow\"><ul class=\"wp-block-post-template is-layout-flow wp-block-post-template-is-layout-flow\"><li class=\"wp-block-post post-283 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h3 class=\"wp-block-post-title has-larger-font-size\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mitigate-trial\/\" target=\"_self\" >MiTiGate trial<\/a><\/h3>\n\n<figure class=\"wp-block-post-featured-image wp-duotone-unset-1\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mitigate-trial\/\" target=\"_self\" ><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"676\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-1200x676.jpeg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"MiTiGate trial\" style=\"object-fit:cover;\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-1200x676.jpeg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-300x169.jpeg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-1024x577.jpeg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-768x432.jpeg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-1536x865.jpeg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-2048x1153.jpeg 2048w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/08\/miti-copy-cropped-1-edited-1-1980x1115.jpeg 1980w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/a><\/figure>\n\n<div class=\"wp-block-post-excerpt has-small-font-size\"><p class=\"wp-block-post-excerpt__excerpt\">MiTiGate Trial: Managing chronic Myalgia Temporomandibular Disorder: a pragmatic randomised controlled trial of Botulinum toxin type A, lidocaine, and amitriptyline\/gabapentin, with internal pilot and cost-effectiveness analysis To learn more, visit the MiTiGate Trial website here: https:\/\/www.mitigatetrial.co.uk\/ To self-refer to the trial, please email nuth.mitigate@nhs.net Plain English summary of the study Temporomandibular disorders (TMD) affect the&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mitigate-trial\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-652 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h3 class=\"wp-block-post-title has-larger-font-size\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mechanism-of-spinal-cord-stimulation-in-the-management-of-chronic-neuropathic-pain\/\" target=\"_self\" >Mechanism of Spinal Cord Stimulation in the management of chronic neuropathic pain<\/a><\/h3>\n\n<figure class=\"wp-block-post-featured-image wp-duotone-unset-2\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mechanism-of-spinal-cord-stimulation-in-the-management-of-chronic-neuropathic-pain\/\" target=\"_self\" ><img loading=\"lazy\" decoding=\"async\" width=\"678\" height=\"680\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/Ilona.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Mechanism of Spinal Cord Stimulation in the management of chronic neuropathic pain\" style=\"object-fit:cover;\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/Ilona.jpg 678w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/Ilona-300x300.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/Ilona-150x150.jpg 150w\" sizes=\"auto, (max-width: 678px) 100vw, 678px\" \/><\/a><\/figure>\n\n<div class=\"wp-block-post-excerpt has-small-font-size\"><p class=\"wp-block-post-excerpt__excerpt\">Spinal cord stimulation (SCS) is used as a safe and effective option for multiple chronic neuropathic pain disorders. While different stimulation paradigms have been implemented into clinical practice, it remains unclear how these paradigms affect the spinal and supraspinal circuits. Evoked compound action potentials (ECAP) have been successfully used as an objective measure to quantify&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mechanism-of-spinal-cord-stimulation-in-the-management-of-chronic-neuropathic-pain\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-584 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h3 class=\"wp-block-post-title has-larger-font-size\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/modulation-of-pain-perception\/\" target=\"_self\" >Modulation of pain perception<\/a><\/h3>\n\n<figure class=\"wp-block-post-featured-image wp-duotone-unset-3\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/modulation-of-pain-perception\/\" target=\"_self\" ><img loading=\"lazy\" decoding=\"async\" width=\"632\" height=\"680\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/quoc.png\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Modulation of pain perception\" style=\"object-fit:cover;\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/quoc.png 632w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/quoc-279x300.png 279w\" sizes=\"auto, (max-width: 632px) 100vw, 632px\" \/><\/a><\/figure>\n\n<div class=\"wp-block-post-excerpt has-small-font-size\"><p class=\"wp-block-post-excerpt__excerpt\">Pain is a salient percept that can draw our attention away from our current task so we can deal with potential bodily harm. We are interested in how our thoughts and actions can help us deal with pain, for example by distracting us from a painful stimulus. To address this, we use different tasks to&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/modulation-of-pain-perception\/\">Read more<\/a><\/p><\/div>\n<\/li><\/ul><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/category\/research\">See all research projects<\/a><\/p>\n\n\n\n<div style=\"height:56px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-center\">Our Research Themes<\/h1>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"726\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1024x726.jpg\" alt=\"\" class=\"wp-image-169 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1024x726.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-300x213.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-768x545.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1536x1089.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1200x851.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1980x1404.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Mechanisms and pathways of pain<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Our work aims to understand how and why acute and persistent pain is experienced in painful conditions such as toothache, persistent facial pain, and neuropathic pain.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading has-text-align-right\">Pain therapeutics and clinical trials<\/h3>\n\n\n\n<p class=\"has-text-align-right wp-block-paragraph\">In this research theme, our work explores new targets to treat painful conditions and assesses the efficacy, safety, and cost-effectiveness of clinical treatments.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1024x682.jpg\" alt=\"\" class=\"wp-image-171 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1024x682.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-300x200.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-768x512.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1536x1024.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1200x800.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1980x1320.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1024x682.jpg\" alt=\"\" class=\"wp-image-172 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1024x682.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-300x200.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-768x512.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1536x1024.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1200x800.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1980x1320.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Pain diagnostics<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">This work aims to improve on the current methods that clinicians have to diagnose pain conditions, and to measure and assess people&#8217;s experience of pain.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading has-text-align-right\">Applied pain research<\/h3>\n\n\n\n<p class=\"has-text-align-right wp-block-paragraph\">Our research uses innovative clinical research, integrating multidisciplinary perspectives, to explore how best to help people who suffer from painful conditions. <\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"695\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1024x695.jpg\" alt=\"\" class=\"wp-image-167 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1024x695.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-300x204.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-768x521.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1536x1042.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1200x814.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1980x1343.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913.jpg 1999w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-center\">Our Collaborators<\/h1>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"684\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1024x684.jpg\" alt=\"\" class=\"wp-image-174 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1024x684.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-300x200.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-768x513.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1536x1025.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1200x801.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1980x1322.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">Academic collaborators<\/h5>\n\n\n\n<ul class=\"wp-block-list has-small-font-size\">\n<li>Osaka University, Japan<\/li>\n\n\n\n<li>University of Minnesota, MN, USA<\/li>\n\n\n\n<li>Aarhus University, Denmark<\/li>\n\n\n\n<li>University of Liverpool, UK<\/li>\n\n\n\n<li>University of Sheffield, UK<\/li>\n\n\n\n<li>University of Leeds, UK<\/li>\n\n\n\n<li>University of Manchester, UK<\/li>\n\n\n\n<li>Durham University, UK<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">Industrial collaborators<\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">We work with several companies in the pharmaceutical and medical device sectors.<\/p>\n\n\n\n<ul class=\"wp-block-list has-small-font-size\">\n<li><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Opportunities to be involved in research The following studies are actively recruiting participants: MiTiGate Trial Elucidate Study FacE-PD study Current projects See all research projects Our Research Themes Mechanisms and pathways of pain Our work aims to understand how and why acute and persistent pain is experienced in painful conditions such as toothache, persistent facial [&hellip;]<\/p>\n","protected":false},"author":8160,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-26","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/26","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/users\/8160"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/comments?post=26"}],"version-history":[{"count":29,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/26\/revisions"}],"predecessor-version":[{"id":751,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/26\/revisions\/751"}],"wp:attachment":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/media?parent=26"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}