{"id":26,"date":"2023-05-25T16:33:56","date_gmt":"2023-05-25T15:33:56","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/painresearch\/?page_id=26"},"modified":"2025-10-14T08:48:50","modified_gmt":"2025-10-14T07:48:50","slug":"research","status":"publish","type":"page","link":"https:\/\/blogs.ncl.ac.uk\/painresearch\/research\/","title":{"rendered":"Our Research"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Opportunities to be involved in research<\/h2>\n\n\n\n<p>The following studies are actively recruiting participants:<\/p>\n\n\n\n<p><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mitigate-trial\/\">MiTiGate Trial<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/elucidate\/\">Elucidate Study<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/face-pd-facial-pain-experience-in-parkinsons-disease\/\">FacE-PD study<\/a> <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left\">Current projects<\/h2>\n\n\n\n<div class=\"wp-block-query is-layout-flow wp-block-query-is-layout-flow\"><ul class=\"wp-block-post-template is-layout-flow wp-block-post-template-is-layout-flow\"><li class=\"wp-block-post post-586 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h3 class=\"wp-block-post-title has-larger-font-size\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/seeking-treatment-for-painful-tmd\/\" target=\"_self\" >Seeking treatment for painful TMD<\/a><\/h3>\n\n<figure class=\"wp-block-post-featured-image wp-duotone-unset-1\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/seeking-treatment-for-painful-tmd\/\" target=\"_self\"  ><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"1200\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/chris-1200x1200.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Seeking treatment for painful TMD\" style=\"object-fit:cover;\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/chris-1200x1200.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/chris-300x300.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/chris-1024x1024.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/chris-150x150.jpg 150w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/chris-768x768.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/chris-1536x1536.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/chris-2048x2048.jpg 2048w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/chris-1980x1980.jpg 1980w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/a><\/figure>\n\n<div class=\"wp-block-post-excerpt has-small-font-size\"><p class=\"wp-block-post-excerpt__excerpt\">The experience of jaw pain that lasts for more than a few months can be an uncertain experience both for patients and professionals. Management may fall between the roles of dentist or GP and many people are unclear about who to consult. Self-management is recommended as first-line treatment, possibly alongside other conservative options. In practice&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/seeking-treatment-for-painful-tmd\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-654 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h3 class=\"wp-block-post-title has-larger-font-size\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/investigating-the-role-of-the-histamine-system-in-chronic-pain\/\" target=\"_self\" >Investigating the role of the histamine system in chronic pain<\/a><\/h3>\n\n<figure class=\"wp-block-post-featured-image wp-duotone-unset-2\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/investigating-the-role-of-the-histamine-system-in-chronic-pain\/\" target=\"_self\"  ><img loading=\"lazy\" decoding=\"async\" width=\"678\" height=\"680\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/Ilona.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Investigating the role of the histamine system in chronic pain\" style=\"object-fit:cover;\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/Ilona.jpg 678w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/Ilona-300x300.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/06\/Ilona-150x150.jpg 150w\" sizes=\"auto, (max-width: 678px) 100vw, 678px\" \/><\/a><\/figure>\n\n<div class=\"wp-block-post-excerpt has-small-font-size\"><p class=\"wp-block-post-excerpt__excerpt\">Histamine, acting through all four types of histamine H1-H4 receptors, is arguably the most pleiotropic molecule in the human body. Since the cloning of H3R in 1999, there has been an increased interest within the pharmaceutical industry to discover and develop ligands to this receptor to target several diseases including neuropathic pain. However, while evidence&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/investigating-the-role-of-the-histamine-system-in-chronic-pain\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-592 post type-post status-publish format-standard hentry category-research\">\n<h3 class=\"wp-block-post-title has-larger-font-size\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mediators-and-moderators-of-change-following-attendance-at-a-pain-management-programme\/\" target=\"_self\" >Mediators and moderators of change following attendance at a Pain Management Programme<\/a><\/h3>\n\n\n\n<div class=\"wp-block-post-excerpt has-small-font-size\"><p class=\"wp-block-post-excerpt__excerpt\">This study proposed an updated cognitive-behavioural model of persistent pain. Predicted relationships between variables informed by the model will be tested using multiple regression analyses, advancing our understanding of how psychological factors can be successfully targeted to improve clinical management of persistent pain.<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mediators-and-moderators-of-change-following-attendance-at-a-pain-management-programme\/\">Read more<\/a><\/p><\/div>\n<\/li><\/ul><\/div>\n\n\n\n<p><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/category\/research\">See all research projects<\/a><\/p>\n\n\n\n<div style=\"height:56px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-center\">Our Research Themes<\/h1>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"726\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1024x726.jpg\" alt=\"\" class=\"wp-image-169 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1024x726.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-300x213.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-768x545.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1536x1089.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1200x851.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919-1980x1404.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61919.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Mechanisms and pathways of pain<\/h3>\n\n\n\n<p>Our work aims to understand how and why acute and persistent pain is experienced in painful conditions such as toothache, persistent facial pain, and neuropathic pain.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading has-text-align-right\">Pain therapeutics and clinical trials<\/h3>\n\n\n\n<p class=\"has-text-align-right\">In this research theme, our work explores new targets to treat painful conditions and assesses the efficacy, safety, and cost-effectiveness of clinical treatments.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1024x682.jpg\" alt=\"\" class=\"wp-image-171 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1024x682.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-300x200.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-768x512.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1536x1024.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1200x800.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870-1980x1320.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/74870.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1024x682.jpg\" alt=\"\" class=\"wp-image-172 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1024x682.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-300x200.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-768x512.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1536x1024.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1200x800.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806-1980x1320.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/69806.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Pain diagnostics<\/h3>\n\n\n\n<p>This work aims to improve on the current methods that clinicians have to diagnose pain conditions, and to measure and assess people&#8217;s experience of pain.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading has-text-align-right\">Applied pain research<\/h3>\n\n\n\n<p class=\"has-text-align-right\">Our research uses innovative clinical research, integrating multidisciplinary perspectives, to explore how best to help people who suffer from painful conditions. <\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"695\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1024x695.jpg\" alt=\"\" class=\"wp-image-167 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1024x695.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-300x204.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-768x521.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1536x1042.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1200x814.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1980x1343.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913.jpg 1999w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-center\">Our Collaborators<\/h1>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"684\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1024x684.jpg\" alt=\"\" class=\"wp-image-174 size-full\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1024x684.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-300x200.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-768x513.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1536x1025.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1200x801.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200-1980x1322.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/63200.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h5 class=\"wp-block-heading\">Academic collaborators<\/h5>\n\n\n\n<ul class=\"wp-block-list has-small-font-size\">\n<li>Osaka University, Japan<\/li>\n\n\n\n<li>University of Minnesota, MN, USA<\/li>\n\n\n\n<li>Aarhus University, Denmark<\/li>\n\n\n\n<li>University of Liverpool, UK<\/li>\n\n\n\n<li>University of Sheffield, UK<\/li>\n\n\n\n<li>University of Leeds, UK<\/li>\n\n\n\n<li>University of Manchester, UK<\/li>\n\n\n\n<li>Durham University, UK<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">Industrial collaborators<\/h5>\n\n\n\n<p>We work with several companies in the pharmaceutical and medical device sectors.<\/p>\n\n\n\n<ul class=\"wp-block-list has-small-font-size\">\n<li><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Opportunities to be involved in research The following studies are actively recruiting participants: MiTiGate Trial Elucidate Study FacE-PD study Current projects See all research projects Our Research Themes Mechanisms and pathways of pain Our work aims to understand how and why acute and persistent pain is experienced in painful conditions such as toothache, persistent facial [&hellip;]<\/p>\n","protected":false},"author":8160,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-26","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/26","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/users\/8160"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/comments?post=26"}],"version-history":[{"count":29,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/26\/revisions"}],"predecessor-version":[{"id":751,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/26\/revisions\/751"}],"wp:attachment":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/media?parent=26"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}