{"id":9,"date":"2023-05-25T16:18:39","date_gmt":"2023-05-25T15:18:39","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/painresearch\/?page_id=9"},"modified":"2024-11-15T17:01:27","modified_gmt":"2024-11-15T17:01:27","slug":"index","status":"publish","type":"page","link":"https:\/\/blogs.ncl.ac.uk\/painresearch\/","title":{"rendered":"Pain Research at Newcastle University"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"695\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1024x695.jpg\" alt=\"\" class=\"wp-image-167\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1024x695.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-300x204.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-768x521.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1536x1042.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1200x814.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1980x1343.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913.jpg 1999w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-accent-color has-text-color\">We explore the frontiers of pain to benefit patients<\/h2>\n\n\n\n<p class=\"has-text-align-center has-normal-font-size wp-block-paragraph\">Our work crosses the disciplines of neuroscience, pharmacy, psychology, and clinical research to better understand and treat pain.<\/p>\n\n\n\n<div style=\"height:49px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/news\/\">Latest news<\/a><\/h2>\n\n\n\n<div class=\"wp-block-query is-layout-flow wp-block-query-is-layout-flow\"><ul class=\"wp-block-post-template is-layout-flow wp-block-post-template-is-layout-flow\"><li class=\"wp-block-post post-735 post type-post status-publish format-standard hentry category-news\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/emma-beecroft-invited-to-present-in-naples-italy-at-the-38th-international-aigedo-congress\/\" target=\"_self\" >Emma Beecroft invited to present In Naples, Italy at the 38th International AIGeDO Congress.\u00a0<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">Emma Beecroft was invited to speak in Naples, Italy, at the 38th International AIGeDO Congress on 10th October 2025. One of the core mission statements of the Italian Association for Gnathology and Orofacial Pain (AIGeDO) is to enhance practitioner expertise and patient care in this specialized field, making Emma&#8217;s invitation to present alongside eminent international&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/emma-beecroft-invited-to-present-in-naples-italy-at-the-38th-international-aigedo-congress\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-609 post type-post status-publish format-standard has-post-thumbnail hentry category-news\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/british-orthodontic-society-asm\/\" target=\"_self\" >British Orthodontic Society ASM<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">Justin was invited to present at this prestigious conference (16th Oct 2024) to discuss the management of TMD and the new guidelines available to help all healthcare professionals with TMD. He also explained some of the latest science behind changes in the mouth and face, pain pathways and central brain changes. His presentation can be&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/british-orthodontic-society-asm\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-554 post type-post status-publish format-standard has-post-thumbnail hentry category-news\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/team-present-work-at-world-endodontic-congress\/\" target=\"_self\" >Team present work at World Endodontic Congress in Glasgow<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">The team were well represented, with Professor Justin Durham, Dr Jamie Coulter, and Dr David Edwards presenting their research at the World Endodontic Congress held in in Glasgow in Sept 2024. Click here to access materials from this conference<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/team-present-work-at-world-endodontic-congress\/\">Read more<\/a><\/p><\/div>\n<\/li><\/ul><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/category\/research\/\">Current projects<\/a><\/h2>\n\n\n\n<div class=\"wp-block-query is-layout-flow wp-block-query-is-layout-flow\"><ul class=\"wp-block-post-template is-layout-flow wp-block-post-template-is-layout-flow\"><li class=\"wp-block-post post-596 post type-post status-publish format-standard hentry category-research\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/sarcopanc-study\/\" target=\"_blank\" >Sarcopanc Study<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">Prospective longitudinal evaluation of Sarcopenia, health-related quality of life and correlation with blood and stool-based microbiome in moderately severe and severe acute pancreatitis.<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/sarcopanc-study\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-140 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/elucidate\/\" target=\"_blank\" >ELUCIDATE: Exploring pain &amp; autonomic dysfunction in ME\/CFS &amp; TMD<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">We are currently looking for people in the northeast of England with ME\/CFS, Temporomandibular Disorders (TMD), or neither of these conditions to take part in this study. If you are interested in taking part, please email james.allison@newcastle.ac.uk for more information. Summary of the study Widespread pain affecting the muscles and joints is a significant problem for people with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS), and has a huge impact on their everyday activities and quality of life. While central sensitisation in the brain and dysfunction of the autonomic nervous system (ANS) are thought to play a role, the precise mechanisms involved&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/elucidate\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-584 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/modulation-of-pain-perception\/\" target=\"_blank\" >Modulation of pain perception<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">Pain is a salient percept that can draw our attention away from our current task so we can deal with potential bodily harm. We are interested in how our thoughts and actions can help us deal with pain, for example by distracting us from a painful stimulus. To address this, we use different tasks to measure how cognition and emotion reduce the pain intensity people feel in response to a painful stimulus. We also investigate brain mechanisms underlying pain perception, particularly in individuals who suffer from persistent chronic pain, and use different stimulation methods that may help modulate pain intensity.<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/modulation-of-pain-perception\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-652 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mechanism-of-spinal-cord-stimulation-in-the-management-of-chronic-neuropathic-pain\/\" target=\"_blank\" >Mechanism of Spinal Cord Stimulation in the management of chronic neuropathic pain<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">Spinal cord stimulation (SCS) is used as a safe and effective option for multiple chronic neuropathic pain disorders. While different stimulation paradigms have been implemented into clinical practice, it remains unclear how these paradigms affect the spinal and supraspinal circuits. Evoked compound action potentials (ECAP) have been successfully used as an objective measure to quantify the effect of SCS in terms of neural activation of dorsal column fibres, as they represent the summation of action potentials generated from the activated fibres. ECAP recordings allow us to optimize SCS treatment by applying stimulation parameters in a consistent and controlled manner, and&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mechanism-of-spinal-cord-stimulation-in-the-management-of-chronic-neuropathic-pain\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-588 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/molecular-interplay-in-progression-of-neuropathic-pain-and-parkinsons-disease\/\" target=\"_blank\" >Molecular Interplay in Progression of Neuropathic pain and Parkinson&#8217;s Disease.<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">This study aims to identify the differential gene and protein expression associated with pain pathways in iPSCs-derived sensory neurons obtained from Parkinson&#8217;s patients or patients with TSC mutations vs iPSCs controls sensory neurons using genetic and proteins analyses. Then determining the functional abnormalities in patients\u2019 iPSC-derived sensory in response to pain stimuli by using functional analyses e.g., calcium imaging, patch-clamp or multi-electrode arrays. By identifying the potentially deregulated proteins in patient models, it will be possible to pinpoint therapeutic targets to reverse the abnormal functional behaviours of patients&#8217; sensory neurons through pharmacological intervention, or by genetic manipulation of the target&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/molecular-interplay-in-progression-of-neuropathic-pain-and-parkinsons-disease\/\">Read more<\/a><\/p><\/div>\n<\/li><\/ul><\/div>\n\n\n\n<div style=\"height:71px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading alignwide has-text-align-center\">Our work is funded by<\/h2>\n\n\n\n<figure class=\"wp-block-gallery aligncenter has-nested-images columns-3 wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" data-id=\"69\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans-1024x1024.png\" alt=\"\" class=\"wp-image-69\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans-1024x1024.png 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans-300x300.png 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans-150x150.png 150w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans-768x768.png 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans.png 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"242\" data-id=\"63\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2-1024x242.png\" alt=\"\" class=\"wp-image-63\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2-1024x242.png 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2-300x71.png 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2-768x181.png 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2-1200x283.png 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2.png 1250w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"490\" height=\"408\" data-id=\"68\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/ukri-mrc-square-logo.png\" alt=\"\" class=\"wp-image-68\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/ukri-mrc-square-logo.png 490w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/ukri-mrc-square-logo-300x250.png 300w\" sizes=\"auto, (max-width: 490px) 100vw, 490px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"715\" height=\"332\" data-id=\"65\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/FDS-Trans.png\" alt=\"\" class=\"wp-image-65\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/FDS-Trans.png 715w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/FDS-Trans-300x139.png 300w\" sizes=\"auto, (max-width: 715px) 100vw, 715px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"680\" height=\"680\" data-id=\"64\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/MEUK-trans.png\" alt=\"\" class=\"wp-image-64\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/MEUK-trans.png 680w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/MEUK-trans-300x300.png 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/MEUK-trans-150x150.png 150w\" sizes=\"auto, (max-width: 680px) 100vw, 680px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"135\" height=\"157\" data-id=\"67\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Picture1.png\" alt=\"\" class=\"wp-image-67\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"230\" data-id=\"70\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/HEE.png\" alt=\"\" class=\"wp-image-70\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/HEE.png 1000w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/HEE-300x69.png 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/HEE-768x177.png 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"326\" height=\"155\" data-id=\"71\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/download.png\" alt=\"\" class=\"wp-image-71\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/download.png 326w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/download-300x143.png 300w\" sizes=\"auto, (max-width: 326px) 100vw, 326px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"596\" height=\"169\" data-id=\"72\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/64192.png\" alt=\"\" class=\"wp-image-72\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/64192.png 596w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/64192-300x85.png 300w\" sizes=\"auto, (max-width: 596px) 100vw, 596px\" \/><\/figure>\n<\/figure>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>We explore the frontiers of pain to benefit patients Our work crosses the disciplines of neuroscience, pharmacy, psychology, and clinical research to better understand and treat pain. Latest news Current projects Our work is funded by<\/p>\n","protected":false},"author":8160,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/users\/8160"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":52,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":672,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/9\/revisions\/672"}],"wp:attachment":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/media?parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}