{"id":9,"date":"2023-05-25T16:18:39","date_gmt":"2023-05-25T15:18:39","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/painresearch\/?page_id=9"},"modified":"2024-11-15T17:01:27","modified_gmt":"2024-11-15T17:01:27","slug":"index","status":"publish","type":"page","link":"https:\/\/blogs.ncl.ac.uk\/painresearch\/","title":{"rendered":"Pain Research at Newcastle University"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"695\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1024x695.jpg\" alt=\"\" class=\"wp-image-167\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1024x695.jpg 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-300x204.jpg 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-768x521.jpg 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1536x1042.jpg 1536w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1200x814.jpg 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913-1980x1343.jpg 1980w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/61913.jpg 1999w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-accent-color has-text-color\">We explore the frontiers of pain to benefit patients<\/h2>\n\n\n\n<p class=\"has-text-align-center has-normal-font-size\">Our work crosses the disciplines of neuroscience, pharmacy, psychology, and clinical research to better understand and treat pain.<\/p>\n\n\n\n<div style=\"height:49px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/news\/\">Latest news<\/a><\/h2>\n\n\n\n<div class=\"wp-block-query is-layout-flow wp-block-query-is-layout-flow\"><ul class=\"wp-block-post-template is-layout-flow wp-block-post-template-is-layout-flow\"><li class=\"wp-block-post post-735 post type-post status-publish format-standard hentry category-news\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/emma-beecroft-invited-to-present-in-naples-italy-at-the-38th-international-aigedo-congress\/\" target=\"_self\" >Emma Beecroft invited to present In Naples, Italy at the 38th International AIGeDO Congress.\u00a0<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">Emma Beecroft was invited to speak in Naples, Italy, at the 38th International AIGeDO Congress on 10th October 2025. One of the core mission statements of the Italian Association for Gnathology and Orofacial Pain (AIGeDO) is to enhance practitioner expertise and patient care in this specialized field, making Emma&#8217;s invitation to present alongside eminent international&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/emma-beecroft-invited-to-present-in-naples-italy-at-the-38th-international-aigedo-congress\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-609 post type-post status-publish format-standard has-post-thumbnail hentry category-news\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/british-orthodontic-society-asm\/\" target=\"_self\" >British Orthodontic Society ASM<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">Justin was invited to present at this prestigious conference (16th Oct 2024) to discuss the management of TMD and the new guidelines available to help all healthcare professionals with TMD. He also explained some of the latest science behind changes in the mouth and face, pain pathways and central brain changes. His presentation can be&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/british-orthodontic-society-asm\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-554 post type-post status-publish format-standard has-post-thumbnail hentry category-news\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/team-present-work-at-world-endodontic-congress\/\" target=\"_self\" >Team present work at World Endodontic Congress in Glasgow<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">The team were well represented, with Professor Justin Durham, Dr Jamie Coulter, and Dr David Edwards presenting their research at the World Endodontic Congress held in in Glasgow in Sept 2024. Click here to access materials from this conference<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/team-present-work-at-world-endodontic-congress\/\">Read more<\/a><\/p><\/div>\n<\/li><\/ul><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/category\/research\/\">Current projects<\/a><\/h2>\n\n\n\n<div class=\"wp-block-query is-layout-flow wp-block-query-is-layout-flow\"><ul class=\"wp-block-post-template is-layout-flow wp-block-post-template-is-layout-flow\"><li class=\"wp-block-post post-652 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mechanism-of-spinal-cord-stimulation-in-the-management-of-chronic-neuropathic-pain\/\" target=\"_blank\" >Mechanism of Spinal Cord Stimulation in the management of chronic neuropathic pain<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">Spinal cord stimulation (SCS) is used as a safe and effective option for multiple chronic neuropathic pain disorders. While different stimulation paradigms have been implemented into clinical practice, it remains unclear how these paradigms affect the spinal and supraspinal circuits. Evoked compound action potentials (ECAP) have been successfully used as an objective measure to quantify [&hellip;]<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/mechanism-of-spinal-cord-stimulation-in-the-management-of-chronic-neuropathic-pain\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-654 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/investigating-the-role-of-the-histamine-system-in-chronic-pain\/\" target=\"_blank\" >Investigating the role of the histamine system in chronic pain<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">Histamine, acting through all four types of histamine H1-H4 receptors, is arguably the most pleiotropic molecule in the human body. Since the cloning of H3R in 1999, there has been an increased interest within the pharmaceutical industry to discover and develop ligands to this receptor to target several diseases including neuropathic pain. However, while evidence [&hellip;]<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/investigating-the-role-of-the-histamine-system-in-chronic-pain\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-590 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/extirpate-study-irreversible-pulpitis\/\" target=\"_blank\" >EXTIRPATE study: Irreversible Pulpitis<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">Dental pain mechanisms remain poorly understood. Outcomes from current approaches to managing acute dental pain are suboptimal. EXTIRPATE focusses on developing a biological model to better understand peripheral and central pain mechanisms, explore the effect of current approaches on these mechanisms and investigate new treatment approaches.<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/extirpate-study-irreversible-pulpitis\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-586 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/seeking-treatment-for-painful-tmd\/\" target=\"_blank\" >Seeking treatment for painful TMD<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">The experience of jaw pain that lasts for more than a few months can be an uncertain experience both for patients and professionals. Management may fall between the roles of dentist or GP and many people are unclear about who to consult. Self-management is recommended as first-line treatment, possibly alongside other conservative options. In practice [&hellip;]<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/seeking-treatment-for-painful-tmd\/\">Read more<\/a><\/p><\/div>\n<\/li><li class=\"wp-block-post post-582 post type-post status-publish format-standard has-post-thumbnail hentry category-research\">\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/investigating-the-role-of-the-kynurenine-pathway-in-irreversible-pulpitis\/\" target=\"_blank\" >Investigating the role of the kynurenine pathway in irreversible pulpitis<\/a><\/h5>\n\n<div class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">The kynurenine pathway is responsible for the catabolism of the essential amino acid kynurenine. This pathway has been linked to acute and chronic pain in animal models of viral infections. Research by the team has shown upregulation of this pathway in pulpititis (toothache) and it appears to be pushing the pathway towards neuroinflammation and pain. [&hellip;]<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/investigating-the-role-of-the-kynurenine-pathway-in-irreversible-pulpitis\/\">Read more<\/a><\/p><\/div>\n<\/li><\/ul><\/div>\n\n\n\n<div style=\"height:71px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading alignwide has-text-align-center\">Our work is funded by<\/h2>\n\n\n\n<figure class=\"wp-block-gallery aligncenter has-nested-images columns-3 wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans-1024x1024.png\" alt=\"\" class=\"wp-image-69\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans-1024x1024.png 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans-300x300.png 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans-150x150.png 150w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans-768x768.png 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Wellcomne-Trans.png 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"242\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2-1024x242.png\" alt=\"\" class=\"wp-image-63\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2-1024x242.png 1024w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2-300x71.png 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2-768x181.png 768w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2-1200x283.png 1200w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/National-Institute-for-Health-Research_logo_outlined_RGB_COL-2.png 1250w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"490\" height=\"408\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/ukri-mrc-square-logo.png\" alt=\"\" class=\"wp-image-68\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/ukri-mrc-square-logo.png 490w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/ukri-mrc-square-logo-300x250.png 300w\" sizes=\"auto, (max-width: 490px) 100vw, 490px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"715\" height=\"332\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/FDS-Trans.png\" alt=\"\" class=\"wp-image-65\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/FDS-Trans.png 715w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/FDS-Trans-300x139.png 300w\" sizes=\"auto, (max-width: 715px) 100vw, 715px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"680\" height=\"680\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/MEUK-trans.png\" alt=\"\" class=\"wp-image-64\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/MEUK-trans.png 680w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/MEUK-trans-300x300.png 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/MEUK-trans-150x150.png 150w\" sizes=\"auto, (max-width: 680px) 100vw, 680px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"135\" height=\"157\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/Picture1.png\" alt=\"\" class=\"wp-image-67\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"230\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/HEE.png\" alt=\"\" class=\"wp-image-70\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/HEE.png 1000w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/HEE-300x69.png 300w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/HEE-768x177.png 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"326\" height=\"155\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/download.png\" alt=\"\" class=\"wp-image-71\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/download.png 326w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/download-300x143.png 300w\" sizes=\"auto, (max-width: 326px) 100vw, 326px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"596\" height=\"169\" src=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/64192.png\" alt=\"\" class=\"wp-image-72\" srcset=\"https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/64192.png 596w, https:\/\/blogs.ncl.ac.uk\/painresearch\/files\/2023\/05\/64192-300x85.png 300w\" sizes=\"auto, (max-width: 596px) 100vw, 596px\" \/><\/figure>\n<\/figure>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>We explore the frontiers of pain to benefit patients Our work crosses the disciplines of neuroscience, pharmacy, psychology, and clinical research to better understand and treat pain. Latest news Current projects Our work is funded by<\/p>\n","protected":false},"author":8160,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/users\/8160"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":52,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":672,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/pages\/9\/revisions\/672"}],"wp:attachment":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/media?parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}