{"id":588,"date":"2024-10-01T10:11:21","date_gmt":"2024-10-01T09:11:21","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/painresearch\/?p=588"},"modified":"2024-10-01T10:11:21","modified_gmt":"2024-10-01T09:11:21","slug":"molecular-interplay-in-progression-of-neuropathic-pain-and-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/blogs.ncl.ac.uk\/painresearch\/molecular-interplay-in-progression-of-neuropathic-pain-and-parkinsons-disease\/","title":{"rendered":"Molecular Interplay in Progression of Neuropathic pain and Parkinson&#8217;s Disease."},"content":{"rendered":"\n<p>This study aims to identify the differential gene and protein expression associated with pain pathways in iPSCs-derived sensory neurons obtained from Parkinson&#8217;s patients or patients with TSC mutations vs iPSCs controls sensory neurons using genetic and proteins analyses. Then determining the functional abnormalities in patients\u2019 iPSC-derived sensory in response to pain stimuli by using functional analyses e.g., calcium imaging, patch-clamp or multi-electrode arrays. By identifying the potentially deregulated proteins in patient models, it will be possible to pinpoint therapeutic targets to reverse the abnormal functional behaviours of patients&#8217; sensory neurons through pharmacological intervention, or by genetic manipulation of the target genes using CRISPR-Cas9 technology.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study aims to identify the differential gene and protein expression associated with pain pathways in iPSCs-derived sensory neurons obtained from Parkinson&#8217;s patients or patients with TSC mutations vs iPSCs controls sensory neurons using genetic and proteins analyses. Then determining the functional abnormalities in patients\u2019 iPSC-derived sensory in response to pain stimuli by using functional [&hellip;]<\/p>\n","protected":false},"author":11472,"featured_media":211,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"_links":{"self":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/posts\/588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/users\/11472"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/comments?post=588"}],"version-history":[{"count":1,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/posts\/588\/revisions"}],"predecessor-version":[{"id":589,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/posts\/588\/revisions\/589"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/media\/211"}],"wp:attachment":[{"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/media?parent=588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/categories?post=588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/painresearch\/wp-json\/wp\/v2\/tags?post=588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}