{"id":21,"date":"2021-10-24T19:42:06","date_gmt":"2021-10-24T18:42:06","guid":{"rendered":"https:\/\/blogs.ncl.ac.uk\/rolyarmstrong\/?page_id=21"},"modified":"2026-01-15T15:55:08","modified_gmt":"2026-01-15T15:55:08","slug":"publications","status":"publish","type":"page","link":"https:\/\/blogs.ncl.ac.uk\/rolyarmstrong\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

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33. Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides<\/strong><\/p>\n\n\n\n

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Keisuke Kondo, Matthew E. Lowe, Nathan Davison, Paul G. Waddell, Roly J. Armstrong,* Erli Lu,* Koji Kubota,* Hajime Ito*<\/p>\n\n\n\n

Nature Synthesis<\/em>, 2025<\/strong>, ASAP<\/p>\n\n\n\n

(DOI: 10.1038\/s44160-025-00949-7<\/a>)<\/p>\n\n\n\n

Highlighted in Chemistry World<\/a><\/p>\n\n\n\n

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32. A Reductive Mechanochemical Approach Enabling Direct Upcycling of Fluoride from Polytetrafluoroethylene (PTFE) into Fine Chemicals<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Matthew E. Lowe, Benjamin M. Gallant, Nathan Davison, Matthew N. Hopkinson, Dominik J. Kubicki,*<\/strong> Erli Lu,*<\/strong> Roly J. Armstrong*<\/strong><\/p>\n\n\n\n

J. Am. Chem. Soc.<\/em> 2025<\/strong>, 147<\/em>, 40895<\/p>\n\n\n\n

(DOI: 10.1021\/jacs.5c14052<\/a>)<\/p>\n\n\n\n

Highlighted in C&EN<\/a> and Chemistry World<\/a><\/p>\n\n\n\n

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31. Red-Shifted Circularly Polarised Luminescence from Helically Chiral N<\/em>,N<\/em>,O<\/em>,O<\/em>-Boron Chelated Dipyrromethenes through Synthetically Facile meso<\/em>-CF3<\/sub> Modification<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Aminah A. Almarshad, Paul G. Waddell, Casey Dixon, Aaron D.G. Campbell, Roly J. Armstrong, Dmitry I. Levshov, Wouter A. Herrebout, Thomas J. Penfold, Dominic J. Black, Robert Pal, Santiago de la Moya,* Julian G. Knight,* Michael J. Hall*<\/p>\n\n\n\n

Dyes and Pigments<\/em>, 2025<\/strong>, ASAP<\/p>\n\n\n\n

(DOI: 10.1016\/j.dyepig.2025.113494)<\/a><\/p>\n\n\n\n

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30. Non-aqueous separation of lithium and sodium perchlorates by selective coordination with a hexadentate semi-flexible amine ligand<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Jack M. Hemingway,* Xiao Yang, Paul G. Waddell, Joel Cornelio, Matthew E. Lowe, James A. Dawson, Peter R. Slater, Roly J. Armstrong, Erli Lu*<\/p>\n\n\n\n

Inorg. Chem. Front.<\/em>, 2025<\/strong>, ASAP<\/p>\n\n\n\n

(DOI: 10.1039\/D5QI01799H)<\/a><\/p>\n\n\n\n

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29. A Multicomponent Approach for the Stereoselective Synthesis of Atropisomeric N\u2013N Peptide Analogues<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Natalie J. Roper, George M. Hardy, Jack M. Wootton, Paul G. Waddell, James Wilson,  Roly J. Armstrong *<\/p>\n\n\n\n

Chem. Commun.<\/em> 2025<\/strong>, 61<\/em>, 17388<\/p>\n\n\n\n

(DOI: 10.1039\/D5CC05091J)<\/a><\/p>\n\n\n\n

Highlighted in Synfacts<\/a><\/p>\n\n\n\n

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28. C=O Methylenation mediated by organo-alkali metal reagents:
metal identity and ligand effects<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Xiao Yang, Nathan Davison,* Matthew E. Lowe, Paul G. Waddell, Roly J. Armstrong,* Claire L. McMullin,* Matthew N. Hopkinson, Erli Lu*<\/p>\n\n\n\n

Chem. Sci. <\/em>2025<\/strong>, 16<\/em>, 11151 <\/p>\n\n\n\n

(https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2025\/sc\/d5sc02313k<\/a>)<\/p>\n\n\n\n

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27. Double Click for Chirality: Chiral Dibenzo-cycloocta-bis-triazoles via Strain-Promoted Alkyne-Azide Cycloaddition<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Sebastian Pim, Aaron D. G. Campbell, Dmitry Levshov, Wouter Herrebout, Gonzalo Dur\u00e1n-Sampedro, Michael J. Hall,* <\/em>Roly J. Armstrong,* Donal F. O\u2019Shea*<\/p>\n\n\n\n

ChemPhotoChem<\/em>, 2025<\/strong>, 9<\/em>, e202500042 <\/p>\n\n\n\n

(https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/cptc.202500042<\/a>)<\/p>\n\n\n\n

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26. CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13<\/strong><\/p>\n\n\n\n

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Journal of Chemical Information and Modeling<\/em>, 2025<\/strong>, 65<\/em>, 6884 <\/p>\n\n\n\n

(https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c00535<\/a>)<\/p>\n\n\n\n

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25. Stereoselective Synthesis of Atropisomeric Amides Enabled by Intramolecular Acyl Transfer<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Jack Wootton, Natalie J. Roper, Catrin E. Morris, Victoria E. Maguire, Lee Duff, Paul G. Waddell, Adrian C. Whitwood, Richard Gammons, Afjal H Miah, Jason M. Lynam, Roly J. Armstrong,* William P. Unsworth*<\/p>\n\n\n\n

Chem. Sci.<\/em> 2025<\/strong>,  16<\/em>, 3938 (https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2025\/sc\/d4sc05760k<\/a>)<\/p>\n\n\n\n

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24. A Stereodivergent Multicomponent Approach for the Synthesis of C\u2013N Atropisomeric Peptide Analogues<\/strong><\/p>\n\n\n<\/p>\n

<\/figure>\n

\"\"<\/p>\n\n\n

Natalie J. Roper, Aaron D. G. Campbell, Paul G. Waddell, Alistair K. Brown, Kristaps Ermanis,* Roly J. Armstrong*<\/p>\n\n\n\n

Chem. Sci.<\/em> 2024<\/strong>, 15<\/em>, 16743 (https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2024\/sc\/d4sc04700a<\/a>)<\/p>\n\n\n\n

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23. Synthesis, Structure and Stereodynamics of Atropisomeric N-Chloroamides<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Aaron D. G. Campbell, Natalie J. Roper, <\/sup> Paul G. Waddell, Corinne Wills, Casey M. Dixon, Ross M. Denton, Kristaps Ermanis,* Roly J. Armstrong*<\/p>\n\n\n\n

Chem. Commun. 2024<\/strong>, 60<\/em>, 3818 (https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2024\/cc\/d4cc00268g<\/a>)<\/p>\n\n\n\n

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22. Interrogating the Configurational Stability of Atropisomers<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Jean-Paul Heeb, Jonathan Clayden,* Martin D. Smith,* Roly J. Armstrong*<\/p>\n\n\n\n

Nature Protocols, <\/em>2023<\/strong>, <\/strong>18<\/em>, 2745 (https:\/\/www.nature.com\/articles\/s41596-023-00859-y<\/a>)<\/p>\n\n\n\n

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21. Redox Reorganization: Aluminium Promoted 1,5-Hydride Shifts Allow the Controlled Synthesis of Multisubstituted Cyclohexenes<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Lewis B. Smith, Roly J. Armstrong, Jingyan Hou, Edward Smith, Ming Sze, Alistair J. Sterling, Alex Smith, Fernanda Duarte,* Timothy J. Donohoe*<\/p>\n\n\n\n

Angew. Chem. Int. Ed<\/em><\/em><\/em><\/em><\/em>. 2023<\/strong>, 62<\/em>, e202307424 (https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202307424<\/a>)<\/p>\n\n\n\n

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20. Synthetic Strategies to Control C\u2013N Atropisomerism in Acyclic Amines and Amides<\/strong><\/p>\n\n\n

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\"\"<\/figure><\/div>\n\n\n

Aaron D. G. Campbell, Roly J. Armstrong*<\/p>\n\n\n\n

Synthesis<\/em> 2023<\/strong>, 55<\/em>, 2427. (DOI: https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/a-2039-5424<\/a>)<\/p>\n\n\n\n

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19. Pentamethylphenyl (Ph*) ketones: Unique building blocks for organic synthesis<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Roly J. Armstrong,* Timothy J. Donohoe*<\/p>\n\n\n\n

Tetrahedron Lett.<\/em> 2021<\/strong>, 74<\/em>, 153151 (DOI: 10.1016\/j.tetlet.2021.153151<\/a>)<\/p>\n\n\n\n

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18. Control of Absolute Stereochemistry in Transition-Metal-Catalyzed Hydrogen Borrowing Reactions<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Timothy Kwok, Oskar Hoff, Roly J. Armstrong,* Timothy J. Donohoe*<\/p>\n\n\n\n

Chem. Eur. J.<\/em> 2020<\/strong>, 26<\/em>, 12912 (DOI: 10.1002\/chem.202001253<\/a>)<\/p>\n\n\n\n

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17. Enantioconvergent Alkylation of Ketones with Racemic Secondary Alcohols via Hydrogen Borrowing Catalysis<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Daniella M. J. Cheang, Roly J. Armstrong, Wasim M. Akhtar, Timothy J. Donohoe*<\/p>\n\n\n\n

Chem. Commun<\/em><\/em>. 2020<\/strong>, 56<\/em>, 3543 (DOI: <\/a>10.1039\/D0CC00767F<\/a>)<\/p>\n\n\n\n

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16. Chemo- and Regioselective Synthesis of Acyl-Cyclohexenes by a Tandem Acceptorless Dehydrogenation-[1,5]-Hydride Shift Cascade<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Lewis B. Smith, Roly J. Armstrong, Daniel Matheau-Raven, Timothy J. Donohoe*<\/p>\n\n\n\n

J. Am. Chem. Soc.<\/em> 2020<\/strong>, 142<\/em>, 2514 (DOI: 10.1021\/jacs.9b12296<\/a>)<\/p>\n\n\n\n

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15. A Hydrogen Borrowing Annulation Strategy for the Stereocontrolled Synthesis of Saturated Aza-Heterocycles<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Anna E. R. Chamberlain, Kieran J. Paterson, Roly J. Armstrong, Heather C. Twin, Timothy J. Donohoe*<\/p>\n\n\n\n

Chem. Commun<\/em>. <\/em><\/em>2020<\/strong>, 56<\/em>, 3563 (DOI: 10.1039\/D0CC00903B<\/a>)<\/p>\n\n\n\n

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14. Synthesis of Allenes by 1,2-Elimination<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

<\/p>\n\n\n\n

Roly J. Armstrong*<\/p>\n\n\n\n

Curr. Org. Chem<\/em>. <\/em><\/em><\/em>2019<\/strong>, 23<\/em>, 3027 (DOI: <\/a>10.2174\/1385272823666191121122011<\/a>)<\/p>\n\n\n\n

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13. Catalytic Asymmetric Synthesis of Cyclohexanes by Hydrogen Borrowing Annulations<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Roly J. Armstrong, Wasim M. Akhtar, Tom A. Young, Fernanda Duarte,* Timothy J. Donohoe*<\/p>\n\n\n\n

Angew. Chem. Int. Ed. <\/em><\/em><\/em><\/em>2019<\/strong>, 58<\/em>, 12558 (DOI: <\/a>10.1002\/anie.201907514<\/a>)<\/p>\n\n\n\n

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12. Stereoselective Synthesis of Alicyclic Ketones: a Hydrogen Borrowing Approach<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Roly J. Armstrong, Wasim M. Akhtar, James R. Frost, Neil G. Stevenson, Timothy J. Donohoe*<\/p>\n\n\n\n

Tetrahedron<\/em> <\/strong><\/em><\/em>2019<\/strong>, 75<\/em>, 130680 (DOI: 10.1016\/j.tet.2019.130680<\/a>)<\/p>\n\n\n\n

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11. Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Wasim M. Akhtar, Roly J. Armstrong, James R. Frost, Neil G. Stevenson, Timothy J. Donohoe*<\/p>\n\n\n\n

J. Am. Chem. Soc.<\/em> <\/strong><\/em><\/em><\/em>2018<\/strong>, 140<\/em>, 11916 (DOI: 10.1021\/jacs.8b07776<\/a>)<\/p>\n\n\n\n

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10. Enantiodivergent Synthesis of Allenes by Point to Axial Chirality Transfer<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Roly J. Armstrong, Meganathan Nandakumar, Rafael M. P. Dias, Adam Noble, Eddie L. Myers, Varinder K. Aggarwal*<\/p>\n\n\n\n

Angew. Chem. Int. Ed. <\/em><\/em><\/em><\/em>2018<\/strong>, 57<\/em>, 8203 (DOI: 10.1002\/anie.<\/a>201804446<\/a>)<\/p>\n\n\n\n

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9. 50 Years of Zweifel Olefination: a Transition-Metal-Free Coupling<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Roly J. Armstrong, Varinder K. Aggarwal*<\/p>\n\n\n\n

Synthesis<\/em> <\/strong><\/em><\/em><\/em><\/em>2017<\/strong>, 49<\/em>, 3323 (DOI: 10.1055\/s-0036-1589046<\/a>)<\/p>\n\n\n\n

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8. Stereodivergent Olefination of Enantioenriched Boronic Esters<\/strong><\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Roly J. Armstrong, Cristina Garc\u00eda-Ruiz, Eddie L. Myers, Varinder K. Aggarwal*<\/p>\n\n\n\n

Angew. Chem. Int. Ed. <\/em><\/em><\/em><\/em><\/em><\/em>2017<\/strong>, 56<\/em>, 786 (DOI: <\/a>10.1002\/anie.201610387<\/a>)<\/p>\n\n\n\n

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7. Conjunctive Functionalization of Vinyl Boronate Complexes with Electrophiles: A Diastereoselective Three-Component Coupling<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Roly J. Armstrong, Christopher Sandford, Cristina Garc\u00eda-Ruiz, Varinder K. Aggarwal*<\/p>\n\n\n\n

Chem. Commun.<\/em> <\/strong>2017<\/strong>, 53<\/em>, 4922 (DOI: 10.1039\/C7CC01671A<\/a>)<\/p>\n\n\n\n

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6. Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Roly J. Armstrong, Worawat Niwetmarin, Varinder K. Aggarwal*<\/p>\n\n\n\n

Org. Lett.<\/em> <\/strong><\/em>2017<\/strong>, 19<\/em>, 2762 (DOI: <\/a>10.1021\/acs.orglett.7b01124<\/a>)<\/p>\n\n\n\n

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5. Homologation of Boronic Esters with Lithiated Epoxides<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Roly J. Armstrong, Varinder K. Aggarwal*<\/p>\n\n\n\n

Org. Synth<\/em>. 2017<\/strong>, 94<\/em>, 234 (DOI: 10.15227\/orgsyn.094.0234<\/a>)<\/p>\n\n\n\n

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4. Catalytic Enantioselective Synthesis of Atropisomeric Biaryls by a Cation-Directed O-Alkylation<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

John. D. Jolliffe, Roly. J. Armstrong, Martin. D. Smith*<\/p>\n\n\n\n

Nat. Chem<\/em>. 2017<\/strong>, 9<\/em>, 558 (DOI: 10.1038\/nchem.2710<\/a>)<\/p>\n\n\n\n

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3. Cation-Directed Enantioselective N-Functionalization of Pyrroles<\/strong><\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

J. Armstrong, Melissa D\u2019Ascenzio, Martin D. Smith*<\/p>\n\n\n\n

Synlett<\/em> 2016<\/strong>, 27<\/em>, 6 (DOI: 10.1055\/s-0035-1560813<\/a>)<\/p>\n\n\n\n

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2. Catalytic Enantioselective Synthesis of Atropisomeric Biaryls: A Cation Directed Nucleophilic Aromatic Substitution Reaction<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Roly J. Armstrong, Martin D. Smith*<\/p>\n\n\n\n

Angew. Chem. Int. Ed.<\/em> 2014<\/strong>, 53<\/em>, 12822 (DOI: 10.1002\/anie.201408205<\/a>)<\/p>\n\n\n\n

\n\n\n\n

1. <\/strong> Furanyl Cyclic Amines: a Diastereoselective Synthesis of 2,6-Syn-Disubstituted Piperidines Under Thermodynamic Control<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Matthew O’Brien,* Andrew Leach, Roly J. Armstrong, Keting Chong, Ross Sheridan<\/p>\n\n\n\n

Org. Biomol. Chem<\/em>. 2012<\/strong>, 10<\/em>, 2392 (DOI: 10.1039\/C2OB07008A<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"

33. Mechanochemical synthesis of organosodium compounds through direct sodiation of organic halides Keisuke Kondo, Matthew E. Lowe, Nathan Davison, Paul G. Waddell, Roly J. Armstrong,* Erli Lu,* Koji Kubota,* Hajime Ito* Nature Synthesis, 2025, ASAP (DOI: 10.1038\/s44160-025-00949-7) Highlighted in Chemistry World 32. A Reductive Mechanochemical Approach Enabling Direct Upcycling of Fluoride from Polytetrafluoroethylene (PTFE) into … <\/p>\n

Continue reading “Publications”<\/span><\/a><\/p>\n","protected":false},"author":10502,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-21","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.ncl.ac.uk\/rolyarmstrong\/wp-json\/wp\/v2\/pages\/21","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.ncl.ac.uk\/rolyarmstrong\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.ncl.ac.uk\/rolyarmstrong\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/rolyarmstrong\/wp-json\/wp\/v2\/users\/10502"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.ncl.ac.uk\/rolyarmstrong\/wp-json\/wp\/v2\/comments?post=21"}],"version-history":[{"count":60,"href":"https:\/\/blogs.ncl.ac.uk\/rolyarmstrong\/wp-json\/wp\/v2\/pages\/21\/revisions"}],"predecessor-version":[{"id":266,"href":"https:\/\/blogs.ncl.ac.uk\/rolyarmstrong\/wp-json\/wp\/v2\/pages\/21\/revisions\/266"}],"wp:attachment":[{"href":"https:\/\/blogs.ncl.ac.uk\/rolyarmstrong\/wp-json\/wp\/v2\/media?parent=21"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}