Research in the McAllister group focuses developing methods to produce glycopeptides and glycoproteins (i.e. peptides and proteins modified with carbohydrates), to investigate the roles of these fundamental biological molecules. Carbohydrates are involved in many important biological processes across all Kingdoms of life including how organisms recognise pathogens, how cancers can spread and the basis of the different A\/B\/O blood groups in humans.<\/p>\n\n\n\n
We have an interest in the recognition of carbohydrates by proteins and the enzymes that generate glycans, particularly N-acetylgalactosamine O-linked glycans, and developing approaches to produce proteins with authentic glycosylation patterns.<\/p>\n\n\n\n
We use a variety of chemical biology approaches techniques including recombinant protein expression, in vitro protein synthesis, solid-phase peptide synthesis, in vitro assays, biophysics and synthetic chemistry.<\/p>\n\n\n\n