New Paper

Congratulations Steven.

Firstly on the MRC grant with Prof Sue Kimber and secondly on the new paper!

Woods S, Barter MJ, Elliott HR, McGillivray CM, Birch MA, Clark IM, Young DA..miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse. Matrix Biol. 2018 Sep 5. pii: S0945-053X(18)30200-2. doi: 10.1016/j.matbio.2018.08.009. PMID: 30193893

The paper describes how miR-324-5p seems to regulate Indian hedgehog signalling in mouse cells via targeting glypican-1 but in human cells by Gli-1 and SMO.

7 November, 2017

Congratulations Matt et al.

Long noncoding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells. Barter MJ¹, Gomez R², Hyatt S³, Cheung K¹, Skelton A¹, Xu Y¹, Clark I⁴, Young DA⁵. Development. 2017 Oct 30. pii: dev.152504. doi: 10.1242/dev.152504. [Epub ahead of print]

3 May, 20173 May, 2017

CRISPR transgenics

CRISPR galore

After a worrying drought we’ve made four CRISPR genomic deletion transgenics

11/4/2017 Even more CRISPR success

29/3/2017 More CRISPR success

23/3/2017 Success!!! CRISPR transgenics

31 March, 20173 May, 2017

Conferences

Well done to Matt at the Gordon Conference (Tuscany) and Bola at the BSMB (Oxford) both of whom gave talks

Long noncoding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells. Barter MJ1, Gomez R2, Hyatt S3, Cheung K1, Skelton A1, Xu Y1, Clark I4, Young DA5. Development. 2017 Oct 30. pii: dev.152504. doi: 10.1242/dev.152504. [Epub ahead of print]