Publications

2024

• McDonnell E, Orr SE, Barter MJ, Rux D, Brumwell A, Wrobel N, Murphy L, Overman LM, Sorial AK, Young DA, Soul J, Rice SJ. The methylomic landscape of human articular cartilage development contains epigenetic signatures of osteoarthritis risk. Am J Hum Genet. 2024 Nov 14:S0002-9297(24)00386-0. doi: 10.1016/j.ajhg.2024.10.017
• Hayman DJ, Johnson de Sousa Brito FM, Lin H, Prior A, Charlesworth G, Hao Y, Pearson RD, Soul J, Clark IM, Piróg KA, Barter MJ, Van’t Hof RJ, Young DA.microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity. Bone. 2024 Oct 9;190:117273. doi: 10.1016/j.bone.2024.117273.
• Patel K, Barter M, Soul J, Clark P, Proctor C, Clark I, Young D, Shanley DP. Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis. Elife. 2024 Oct 14;12:RP89701. doi: 10.7554/eLife.89701.
• Gilbert SJ, Soul J, Hao Y, Lin H, Piróg KA, Coxhead J, Patel K, Barter MJ, Young DA, Blain EJ.  Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis mouse models.  Dis Model Mech. 2024 Sep 24:dmm.050583. doi: 10.1242/dmm.050583.
• Barter MJ, Turner DA, Rice SJ, Hines M, Lin H, Falconer AMD, McDonnell E, Soul J, Arques MDC, Europe-Finner GN, Rowan AD, Young DA, Wilkinson DJ. SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesis. Matrix Biol. 2024 Nov;133:33-42. doi: 10.1016/j.matbio.2024.07.004. Epub 2024 Aug 2.
• Tamblin-Hopper P, Kiss-Toth E, Sudbery I,  Young DA, Wilkinson JM. The potential therapeutic applications of long non-coding RNAs. J Transl Genet Genom 2024;8:225-43. 10.20517/jtgg.2024.12 

2023

• Gómez R, Barter MJ, Alonso-Pérez A, Skelton AJ, Proctor C, Herrero-Beaumont G, Young DA. DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation. Biol Res. 2023 Mar 8;56(1):9. doi: 10.1186/s40659-023-00417-6.

2022

• Barter MJ, Butcher A, Wang H, Tsompani D, Galler M, Rumsby EL, Culley KL, Clark IM, Young DA.  HDAC6 regulates NF-κB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression. Sci Rep. 2022 Apr 22;12(1):6640. doi: 10.1038/s41598-022-10518-z.
• Chaudhry N, Muhammad H, Seidl C, Downes D, Young DA, Hao Y, Zhu L, Vincent TL. Highly efficient CRISPR-Cas9-mediated editing identifies novel mechanosensitive microRNA-140 targets in primary human articular chondrocytes. Osteoarthritis Cartilage. 2022 Jan 21:S1063-4584(22)00009-7. doi: 10.1016/j.joca.2022.01.005. Online ahead of print.
• Young DA, Barter MJ, Soul J. Osteoarthritis year in review: genetics, genomics, epigenetics. Osteoarthritis Cartilage. 2022 Feb;30(2):216-225. doi: 10.1016/j.joca.2021.11.004. Epub 2021 Nov 11.

2021

• Wilkinson DJ, Falconer AMD, Wright HL, Lin H, Yamamoto K, Cheung K, Charlton SH, Arques MDC, Janciauskiene S, Refaie R, Rankin KS, Young DA, Rowan AD. Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis. FEBS J. 2021 Jul 16. doi: 10.1111/febs.16127.
• Jones TL, Esa MS, Li KHC, Krishnan SRG, Elgallab GM, Pearce MS, Young DA, Birrell FN. Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association. Bone. 2021 Jun 21:116068. doi: 10.1016/j.bone.2021.116068.
• Hayman DJ, Modebadze T, Charlton S, Cheung K, Soul J, Lin H, Hao Y, Miles CG, Tsompani D, Jackson RM, Briggs MD, Piróg KA, Clark IM, Barter MJ, Clowry GJ, LeBeau FEN, Young DA. Increased hippocampal excitability in miR-324-null mice. Sci Rep. 2021 May 17;11(1):10452. doi: 10.1038/s41598-021-89874-1.
• Patel K, Chandrasegaran S, Clark IM, Proctor CJ, Young DA, Shanley DP.
  TimiRGeN: R/Bioconductor package for time series microRNA-mRNA integration and analysis. Bioinformatics. 2021 May 16:btab377. doi: 10.1093/bioinformatics/btab377

2020

• Le L, Niu L, Barter MJ, Young DA, Dalmay T, Clark IM, Swingler TE. The role of microRNA-3085 in chondrocyte function. Sci Rep. 2020 Dec 14;10(1):21923. doi: 10.1038/s41598-020-78606-6.
• Soul J, Barter MJ, Little CB, Young DA. OATargets: a knowledge base of genes associated with osteoarthritis joint damage in animals. Ann Rheum Dis. 2020 Oct 19:annrheumdis-2020-218344. doi: 10.1136/annrheumdis-2020-218344.
• Stadnik PS, Gilbert SJ, Tarn J, Charlton S, Skelton AJ, Barter MJ, Duance VC, Young DA, Blain EJ. Regulation of microRNA-221, -222, -21 and -27 in articular cartilage subjected to abnormal compressive forces.J Physiol. 2020 Oct 14. doi: 10.1113/JP279810. Online ahead of print
• Barter MJ, Cheung K, Falk J, Panagiotopoulos AC, Cosimini C, O’Brien S, Teja-Putri K, Neill G, Deehan DJ, Young DA. Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation. Epigenetics. 2020 Aug 2:1-14. doi: 10.1080/15592294.2020.1789266. Online ahead of print.PMID: 32741307
• Woods S, Charlton S, Cheung K, Hao Y, Soul J, Reynard LN, Crowe N, Swingler TE, Skelton AJ, Piróg KA, Miles CG, Tsompani D, Jackson RM, Dalmay T, Clark IM, Barter MJ, Young DA.microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs. RNA. 2020 Jul 13:rna.075176.120. doi: 10.1261/rna.075176.120.
• Rice SJ, Beier F, Young DA, Loughlin J. Interplay between genetics and epigenetics in osteoarthritis. Nat Rev Rheumatol. 2020 Apr 9. doi: 10.1038/s41584-020-0407-3. Review.
• Dennis EP, Edwards SM, Jackson RM, Hartley CL, Tsompani D, Capulli M, Teti A, Boot-Handford RP, Young DA, Piróg KA, Briggs MD. CRELD2 is a novel LRP1 chaperone that regulates non-canonical WNT signalling in skeletal development. J Bone Miner Res. 2020 Mar 17. doi: 10.1002/jbmr.4010.
• Cheung K, Barter MJ, Falk J, Proctor CJ, Reynard LN, Young DA. Histone ChIP-Seq identifies differential enhancer usage during chondrogenesis as critical for defining cell-type specificity. FASEB J. 2020 Feb 14. doi: 10.1096/fj.201902061RR.
• Barter MJ, Bui C, Cheung K, Falk J, Gómez R, Skelton AJ, Elliott HR, Reynard LN, Young DA. DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions. Sci Rep. 2020 Jan 24;10(1):1169. doi: 10.1038/s41598-020-58093-5.

2019

• Cheung K, Burgers MJ, Young DA, Cockell S, Reynard LN. Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage. Epigenetics. 2019 Dec 13:1-10. doi: 10.1080/15592294.2019.1700003.
• Swingler TE, Niu L, Smith P, Paddy P, Le L, Barter MJ, Young DA, Clark IM. The function of microRNAs in cartilage and osteoarthritis. Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 120(5):40-47. Epub 2019 Oct 15. Review.
• Coelho-Lima J, Mohammed A, Cormack S, Jones S, Ali A, Panahi P, Barter M, Bagnall A, Ali S, Young D, Spyridopoulos I. Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion. Clin Chem. 2019 Oct 31. pii: clinchem.2019.308353. doi: 10.1373/clinchem.2019.308353.
• Young DA, Barter MJ, Wilkinson DJ. Recent advances in understanding the regulation of metalloproteinases. F1000Research 2019, 8(F1000 Faculty Rev):195
• Ajekigbe B, Cheung K, Xu Y, Skelton AJ, Panagiotopoulos A, Soul J, Hardingham TE, Deehan DJ, Barter MJ, Young DA. Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage. Osteoarthritis Cartilage. 2019 Jan 3. pii: S1063-4584(18)31594-2. doi: 10.1016/j.joca.2018.12.015.

2018

• Woods S, Barter MJ, Elliott HR, McGillivray CM, Birch MA, Clark IM, Young DA. miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse. Matrix Biol. 2018 Sep 5. pii: S0945-053X(18)30200-2. doi:10.1016/j.matbio.2018.08.009.

2017

• Barter MJ, Gomez R, Hyatt S, Cheung K, Skelton A, Xu Y, Clark I, Young DA.  
  The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells. Development 2017 Dec 15;144(24):4510-4521. doi: 10.1242/dev.152504. Epub 2017 Oct 30.
• Steinbusch MMF, Fang Y, Milner PI, Clegg PD, Young DA, Welting TJM, Peffers MJ. Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis. Scientific Reports 2017, 7, 43558.

2016

• Crowe N, Swingler TE, Le LTT, Barter MJ, Wheeler G, Pais H, Donell ST, Young DA, Dalmay T, Clark IM. Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA. Osteoarthritis and Cartilage 2016, 24(3), 534-543.
• Le LTT, Swingler TE, Crowe N, Vincent TL, Barter MJ, Donell ST, Delany AM, Dalmay T, Young DA, Clark IM. The microRNA-29 family in cartilage homeostasis and osteoarthritis. Journal of Molecular Medicine 2016, 94(5), 583-596.

2015

• Rushton MD, Young DA, Loughlin J, Reynard LN. Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients. Annals of the Rheumatic Diseases 2015, 74(9), 1778-1782.
• Barter MJ, Tselepi M, Gomez R, Woods S, Hui W, Smith GR, Shanley DP, Clark IM, Young DA. Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p. Stem Cells 2015, 33(11), 3266-3280.
• Rushton MD, Reynard LN, Young DA, Shepherd C, Aubourg G, Gee F, Darlay R, Deehan D, Cordell HJ, Loughlin J. Methylation quantitative trait locus (meQTL) analysis of osteoarthritis links epigenetics with genetic risk. Human Molecular Genetics 2015, 24(25), 7432-7444.

2014 and earlier

• Purvis HA, Anderson AE, Young DA, Isaacs JD, Hilkens CMU. A Negative Feedback Loop Mediated by STAT3 Limits Human Th17 Responses. Journal of Immunology 2014, 193(3), 1142-1150.
• Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, Young DA, Loughlin J. Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis & Rheumatology 2014, 66(9), 2450–2460.
• Litherland GJ, Hui W, Elias MS, Wilkinson DJ, Watson S, Huesa C, Young DA, Rowan AD. Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis. Arthritis & Rheumatology 2014, 66(8), 2175-2187.
• Hui W, Young DA, Rowan AD, Xu X, Cawston TE, Proctor CJ. Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage. Annals of the Rheumatic Diseases 2014, 1-10.
• Radwan M, Wilkinson DJ, Hui W, Destrument AP, Charlton SH, Barter MJ, Gibson B, Coulombe J, Gray DA, Rowan AD, Young DA. Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination. Annals of the Rheumatic Diseases 2014.
• Barter MJ, Young DA. Epigenetic Mechanisms and Non-coding RNAs in Osteoarthritis. Current Rheumatology Reports 2013, 15(9), 353.
• Radwan M, Gavriilidis C, Robinson JH, Davidson R, Clark IM, Rowan AD, Young DA. Matrix metalloproteinase-13 expression in response to double-stranded RNA in human chondrocytes. Arthritis & Rheumatism 2013, 65(5), 1290-1301.
• Gavriilidis C, Miwa S, von Zglinicki T, Taylor RW, Young DA. Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2. Arthritis & Rheumatism 2013, 65(2), 378-387.
• Young DA. More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis. Arthritis and Rheumatism 2013, 65(3), 555-558.
• Syddall CM, Reynard LN, Young DA, Loughlin J. The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383. PLoS Genetics 2013, 9(6), e1003557.
• Pratt AG, Swan DC, Richardson S, Wilson G, Hilkens C, Young DA, Isaacs JD. A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly anti-citrullinated peptide antibody-negative disease. Annals of the Rheumatic Diseases 2012, 71(8), 1374-1381.
• Bui C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA. cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis. FASEB Journal 2012, 26(7), 3000-3011.
• Barter MJ, Bui C, Young DA. Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs. Osteoarthritis and Cartilage 2012, 20(5), 339-349.
• Xu Y, Barter MJ, Swan DC, Rankin KS, Rowan AD, Santibanez-Koref M, Loughlin J, Young DA. Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA. Osteoarthritis and Cartilage 2012, 20(9), 1029-1038.
• Hui W, Litherland GJ, Elias MS, Kitson GI, Cawston TE, Rowan AD, Young DA. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Annals of the Rheumatic Diseases 2012, 71(3), 455-462.
• Swingler TE, Wheeler G, Carmont V, Elliott HR, Barter MJ, Abu-Elmagd M, Donell ST, Boot-Handford RP, Hajihosseini MK, Münsterberg A, Dalmay T, Young DA, Clark IM. The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis and Rheumatism 2012, 64(6), 1909-1919.
• Young DA, Bui C, Barter MJ. Understanding CpG methylation in the context of osteoarthritis. Epigenomics 2012, 4(6), 593-595.
• Reynard LN, Bui C, Canty-Laird EG, Young DA, Loughlin J. Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation. Human Molecular Genetics 2011, 20(17), 3450-3460.
• Cui Y, Yu J, Urban JPG, Young DA. Differential Gene Expression Profiling of Metalloproteinases and Their Inhibitors A Comparison Between Bovine Intervertebral Disc Nucleus Pulposus Cells and Articular Chondrocytes. Spine 2010, 35(11), 1101-1108.
• Barter MJ, Pybus L, Litherland GJ, Rowan AD, Clark IM, Edwards DR, Cawston TE, Young DA. HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes. Matrix Biology 2010, 29(7), 602-612.
• Barter MJ, Hui W, Lakey RL, Catterall JB, Cawston TE, Young DA. Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. Annals of the Rheumatic Diseases 2010, 69(12), 2189-2198.
• Hui W, Litherland GJ, Jefferson M, Barter MJ, Elias MS, Cawston TE, Rowan AD, Young DA. Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway. Rheumatology 2010, 49(11), 2043-2053.
• Milner JM, Patel A, Davidson RK, Swingler TE, Desilets A, Young DA, Kelso EB, Donell ST, Cawston TE, Clark IM, Ferrell WR, Plevin R, Lockhart JC, Leduc R, Rowan AD. Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis & Rheumatism 2010, 62(7), 1955-1966.
• Swingler TE, Kevorkian L, Culley KL, Illman SA, Young DA, Parker AE, Lohi J, Clark IM. MMP28 gene expression is regulated by Sp1 transcription factor acetylation. Biochemical Journal 2010, 427, 391-400.
• Cawston TE, Young DA. Proteinases involved in matrix turnover during cartilage and bone breakdown. Cell and Tissue Research 2010, 339(1), 221-235.
• Scott JL, Gabrielides C, Davidson RK, Swingler TE, Clark IM, Wallis GA, Boot-Handford RP, Kirkwood TBL, Talyor RW, Young DA. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Annals of the Rheumatic Diseases 2010, 69(8), 1502-1510.