Banner images explained

Science is beautiful!

In our research we do not only answer important scientific questions, but also generate beautiful images on the tissues and proteins that we work with. We’ve used a selection of them as backgrounds on our website. Have a look below for a brief explanation.

 

In situ hybridisation showing the expression of type II collagen (red) and type X collagen (green) in the cartilage growth plate. Type X is a marker of hypertrophic chondrocytes at the bottom of the growth plate.


Transmission electron microscopy image showing a tenocyte (tendon cell) embedded in the matrix of type I collagen (grey circles are collagen bundles)

 

In situ hybridisation looking at expression of type Indain Hedhehog (Ihh) in mouse growth plate.

 

Immunohistochemistry for matrilin 3 (green) and type II collagen (red) in the cartilage growth plate. The nuclei are stained blue (DAPI).

 

3D reconstruction of a chondron from mice harbouring V194D matrilin-3 mutation (spot the enlarged ER inside the cells, full of mutant protein!)

 

Cells cultured on plastic expressing matrilin 3 (in green). Matrilin 3 appears to associate with matrix microfibrils.

 

Adipocytes differentiated from mesenchymal stem cells.

 

A collage of Picrosirus Red (orange) and DAPI (slightly overexposed; grey) staining of decellularised (bottom half) and cell-seeded decellularised (top half) murine femoral heads.