List of lab’s publications | Musculoskeletal Genetics

Hayman DJ, Johnson de Sousa Brito FM, Lin H, Prior A, Charlesworth G, Hao Y, Pearson RD, Soul J, Clark IM, Piróg KA, Barter MJ, Van’t Hof RJ, Young DA. microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity. Bone, 2025; 190, 117273.
Gilbert SJ, Soul J, Hao Y, Lin H, Piróg KA, Coxhead J, Patel K, Barter MJ, Young DA, Blain EJ. Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis mouse models. Dis Model Mech, 2024; 17(10): dmm050583.
Farcasanu M*, de las Heras Ruiz T*, Johnson de Sousa Brito FM, Soul J, German M, Young DA, Ferreira-Duarte A, Pirog KA. Dynamic compression improves chondrogenesis in the tissue engineered model of cartilage. Biotechnology and Bioengineering 2024 (under review).
Johnson de Sousa Brito FM, Bouchenafa R, Pearson RD, Pirog KA. Microtubule-associated motor proteins in skeletal development and health, a chapter in “The Extracellular Matrix in genetic skeletal disorders” Springer 2024 (accepted).
Bouchenafa R, Johnson de Sousa Brito FM, Pirog KA. Involvement of kinesins in skeletal dysplasia – a review. 2024 Apr 22. doi: 10.1152/ajpcell.00613.2023. Online ahead of print.
de las Heras Ruiz T, Johnson de Sousa Brito FM, Farcasanu M, Howe S, Young D, Pirog KA. Dynamic compression dramatically improves the chondrogenic potential of ATDC5 cells in the tissue engineered model of healthy and PSACH cartilage. Int J Exp Path. 2022;103:A1–A14.
Hayman DJ, Modebadze T, Charlton S, Cheung K, Soul J, Lin H, Hao Y, Miles CG, Tsompani D, Jackson RM, Briggs MD, Pirog KA, Clark IM, Barter MJ, Clowry GJ, LeBeau FEN & Young DA. Increased hippocampal excitability in miR‑324‑null mice. Scientific Reports 2021, 11:10452
E. P. Dennis; F. M. Johnson de Sousa Brito; R. D. Pearson; R. M. Jackson; J. Logan; M. Capulli; A. Teti; J. H. Duncan Bassett; G. R. Williams; S. Kalamajski; K. A. Pirog. Asporin is important in bone development but not in cartilage homeostasis. Int J Exp Path. 2021;102:A1–A17.
Woods S, Charlton S, Cheung K, Hao Y, Soul J, Reynard LN, Crowe N, Swingler TE, Skelton AJ, Pirog KA, Miles CG, Tsompani D, Jackson RM, Dalmay T, Clark IM, Barter MJ, Young DA. microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs RNA 2020, 26(11):1575-1588.
Briggs MD, Dennis EP, Dietmar H, Pirog KA. New developments in chondrocyte ER-stress and related diseases. F1000Research 2020, 9 (F1000 Faculty Rev):290
Dennis EP, Edwards S, Jackson RM, Capulli M, Teti A, Ishiguro K, Pirog KA, Briggs MD. CRELD2 is a novel LRP1 chaperone that regulates non-canonical WNT signalling in skeletal development. JBMR 2020, 35 (8):1452-1469
Piróg KA, Dennis EP, Hartley CL, Jackson RM, Soul J, Schwartz JM, Bateman JF, Boot-Handford RP, Briggs MD. XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease. PLoS Genetics 2019, 15(7), e1008215.
Paganini C, Monti L, Costantini R, Besio R, Lecci S, Biggiogera M, Tian K, Schwartz JM, Huber C, Cormier-Daire V, Gibson BG, Pirog KA, Forlino A, Rossi A. Calcium activated nucleotidase 1 (CANT1) is critical for glycosaminoglycan biosynthesis in cartilage and endochondral ossification. Matrix Biology 2018, pii: S0945-053X(18)30397-4.
Briggs MD, Bell PA, Pirog KA. Pseudoachondroplasia and Multiple Epiphyseal Dysplasia: Molecular Genetics, Disease Mechanisms and Therapeutic Targets. In: Cartilage, Volume 2: Pathophysiology. Springer International Publishing AG, 2017.
de-las-Heras-Ruiz T, Pirog KA. Tissue Engineering Approaches for the Study and Therapeutic Intervention in Osteoarthritis. In: Osteoarthritis. SM Group Open Access eBooks, 2016.
Dennis EP, Capulli M, Teti A, Pirog KA, Briggs MD. The role of Creld2 in skeletal development and homeostasis. In: 43rd Annual European Calcified Tissue Society Congress. 2016, Rome, Italy: Bone Abstracts.
Gibson BG, Sonntag S, Selbert S, Pirog KA, Briggs MD. Transgenic mice with an allelic series of aggrecan mutations model the human phenotypes. In: British Society for Matrix Biology / Bone Research Society Third Joint Meeting. 2015, Edinburgh: Wiley-Blackwell Publishing Ltd.
Cameron TL, Gresshoff IL, Bell KM, Pirog KA, Sampurno L, Hartley CL, Sanford EM, Wilson R, Ermann J, Boot-Handford RP, Glimcher LH, Briggs MD, Bateman JF. Cartilage-Specific Ablation of XBP1 Signaling in Mouse Results in a Chondrodysplasia Characterized by Reduced Chondrocyte Proliferation and Delayed Cartilage Maturation and Mineralization. Osteoarthritis and Cartilage 2015, 23, 661-670.
Dennis EP, Edwards SM, Boot-Handford RP, Pirog KA, Briggs MD. The role of CRELD2 in skeletal development and homeostasis. In: British Society for Matrix Biology / Bone Research Society Third Joint Meeting. 2015, Edinburgh: Wiley-Blackwell Publishing Ltd.
Briggs MD, Bell PA, Wright MJ, Pirog KA. New therapeutic targets in rare genetic skeletal diseases. Expert Opinion on Orphan Drugs 2015, 3(10), 1137-1154.
Briggs MD, Bell PA, Pirog KA. The utility of mouse models to provide information regarding the pathomolecular mechanisms in human genetic skeletal diseases: The emerging role of endoplasmic reticulum stress (Review). International Journal of Molecular Medicine 2015, 1483-1492.
Pirog KA, Irman A, Young S, Halai P, Bell PA, Boot-Handford RP, Briggs MD. Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia. PLoS One 2014, 9(2), e85145.
Pirog KA, Katakura Y, Mironov A, Briggs MD. Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases. PLoS One 2013, 8(11), e82412.
Pirog KA, Meadows RS, Boot-Handford RP, Briggs MD. Mutant chondrocytes are characterised by altered cell shape and changes to the organisation of primary cilia in a genetic mouse model of mild pseudoachondroplasia. In: British Society for Matrix Biology Autumn 2013 Meeting. 2013, Cardiff: Wiley-Blackwell.
Suleman F, Gualeni B, Gregson HJ, Leighton MP, Pirog KA, Edwards S, Holden P, Boot-Handford RP, Briggs MD. A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia. Human Mutation 2012, 33(1), 218-231.
Bell PA, Pirog KA, Fresquet M, Thornton DJ, Boot-Handford RP, Briggs MD. Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation. Arthritis & Rheumatism 2012, 64(5), 1529-1539.
Pirog KA, Jaka O, Katakura Y, Meadows RS, Kadler KE, Boot-Handford RP, Briggs MD. A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia. Human Molecular Genetics 2010, 19(1), 52-64.
Pirog KA, Briggs MD. Skeletal Dysplasias Associated with Mild Myopathy-A Clinical and Molecular Review. Journal of Biomedicine and Biotechnology 2010, Article no. 686457.
Pirog-Garcia KA, Meadows RS, Knowles L, Heinegard D, Thornton DJ, Kadler KE, Boot-Handford RP, Briggs MD. Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP. Human Molecular Genetics 2007, 16(17), 2072-2088.
Pirog KA, Kowalczyk AK, Rokita HB. Changes in Bcl-2 expression in vaccinia virus-infected human peripheral blood monocytes. Viral Immunology 2005, 18(1), 224-231.
Pirog KA. Terapia genowa (Gene therapy). Wydaw: Jagiellonian University Press, 2002.