Stereoselective Synthesis of Atropisomeric Amides Enabled by Intramolecular Acyl Transfer
Jack Wootton, Natalie J. Roper, Catrin E. Morris, Victoria E. Maguire, Lee Duff, Paul G. Waddell, Adrian C. Whitwood, Richard Gammons, Afjal H Miah, Jason M. Lynam, Roly J. Armstrong,* William P. Unsworth*
Chem. Sci. 2025, ASAP (https://pubs.rsc.org/en/content/articlelanding/2025/sc/d4sc05760k)
A Stereodivergent Multicomponent Approach for the Synthesis of C–N Atropisomeric Peptide Analogues
Natalie J. Roper, Aaron D. G. Campbell, Paul G. Waddell, Alistair K. Brown, Kristaps Ermanis,* Roly J. Armstrong*
Chem. Sci. 2024, 15, 16743. (https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc04700a)
Synthesis, Structure and Stereodynamics of Atropisomeric N-Chloroamides
Aaron D. G. Campbell, Natalie J. Roper, Paul G. Waddell, Corinne Wills, Casey M. Dixon, Ross M. Denton, Kristaps Ermanis,* Roly J. Armstrong*
Chem. Commun. 2023, 60, 3818 (https://pubs.rsc.org/en/content/articlelanding/2024/cc/d4cc00268g)
Interrogating the Configurational Stability of Atropisomers
Jean-Paul Heeb, Jonathan Clayden,* Martin D. Smith,* Roly J. Armstrong*
Nature Protocols, 2023, 18, 2745 (https://www.nature.com/articles/s41596-023-00859-y)
Redox Reorganization: Aluminium Promoted 1,5-Hydride Shifts Allow the Controlled Synthesis of Multisubstituted Cyclohexenes
Lewis B. Smith, Roly J. Armstrong, Jingyan Hou, Edward Smith, Ming Sze, Alistair J. Sterling, Alex Smith, Fernanda Duarte,* Timothy J. Donohoe*
Angew. Chem. Int. Ed. 2023, 62, e202307424 (https://onlinelibrary.wiley.com/doi/10.1002/anie.202307424)
Synthetic Strategies to Control C–N Atropisomerism in Acyclic Amines and Amides
Aaron D. G. Campbell, Roly J. Armstrong*
Synthesis 2023, 55, 2427 (DOI: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2039-5424)
Pentamethylphenyl (Ph*) ketones: Unique building blocks for organic synthesis
Roly J. Armstrong,* Timothy J. Donohoe*
Tetrahedron Lett. 2021, 74, 153151 (DOI: 10.1016/j.tetlet.2021.153151)
Control of Absolute Stereochemistry in Transition-Metal-Catalyzed Hydrogen Borrowing Reactions
Timothy Kwok, Oskar Hoff, Roly J. Armstrong,* Timothy J. Donohoe*
Chem. Eur. J. 2020, 26, 12912 (DOI: 10.1002/chem.202001253)
Enantioconvergent Alkylation of Ketones with Racemic Secondary Alcohols via Hydrogen Borrowing Catalysis
Daniella M. J. Cheang, Roly J. Armstrong, Wasim M. Akhtar, Timothy J. Donohoe*
Chem. Commun. 2020, 56, 3543 (DOI: 10.1039/D0CC00767F)
Chemo- and Regioselective Synthesis of Acyl-Cyclohexenes by a Tandem Acceptorless Dehydrogenation-[1,5]-Hydride Shift Cascade
Lewis B. Smith, Roly J. Armstrong, Daniel Matheau-Raven, Timothy J. Donohoe*
J. Am. Chem. Soc. 2020, 142, 2514 (DOI: 10.1021/jacs.9b12296)
A Hydrogen Borrowing Annulation Strategy for the Stereocontrolled Synthesis of Saturated Aza-Heterocycles
Anna E. R. Chamberlain, Kieran J. Paterson, Roly J. Armstrong, Heather C. Twin, Timothy J. Donohoe*
Chem. Commun. 2020, 56, 3563 (DOI: 10.1039/D0CC00903B)
Synthesis of Allenes by 1,2-Elimination
Roly J. Armstrong*
Curr. Org. Chem. 2019, 23, 3027 (DOI: 10.2174/1385272823666191121122011)
Catalytic Asymmetric Synthesis of Cyclohexanes by Hydrogen Borrowing Annulations
Roly J. Armstrong, Wasim M. Akhtar, Tom A. Young, Fernanda Duarte,* Timothy J. Donohoe*
Angew. Chem. Int. Ed. 2019, 58, 12558 (DOI: 10.1002/anie.201907514)
Stereoselective Synthesis of Alicyclic Ketones: a Hydrogen Borrowing Approach
Roly J. Armstrong, Wasim M. Akhtar, James R. Frost, Neil G. Stevenson, Timothy J. Donohoe*
Tetrahedron 2019, 75, 130680 (DOI: 10.1016/j.tet.2019.130680)
Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy,
Wasim M. Akhtar, Roly J. Armstrong, James R. Frost, Neil G. Stevenson, Timothy J. Donohoe*
J. Am. Chem. Soc. 2018, 140, 11916 (DOI: 10.1021/jacs.8b07776)
Enantiodivergent Synthesis of Allenes by Point to Axial Chirality Transfer
Roly J. Armstrong, Meganathan Nandakumar, Rafael M. P. Dias, Adam Noble, Eddie L. Myers, Varinder K. Aggarwal*
Angew. Chem. Int. Ed. 2018, 57, 8203 (DOI: 10.1002/anie.201804446)
50 Years of Zweifel Olefination: a Transition-Metal-Free Coupling
Roly J. Armstrong, Varinder K. Aggarwal*
Synthesis 2017, 49, 3323 (DOI: 10.1055/s-0036-1589046)
Stereodivergent Olefination of Enantioenriched Boronic Esters
Roly J. Armstrong, Cristina García-Ruiz, Eddie L. Myers, Varinder K. Aggarwal*
Angew. Chem. Int. Ed. 2017, 56, 786 (DOI: 10.1002/anie.201610387)
Conjunctive Functionalization of Vinyl Boronate Complexes with Electrophiles: A Diastereoselective Three-Component Coupling
Roly J. Armstrong, Christopher Sandford, Cristina García-Ruiz, Varinder K. Aggarwal*
Chem. Commun. 2017, 53, 4922 (DOI: 10.1039/C7CC01671A)
Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling
Roly J. Armstrong, Worawat Niwetmarin, Varinder K. Aggarwal*
Org. Lett. 2017, 19, 2762 (DOI: 10.1021/acs.orglett.7b01124)
Homologation of Boronic Esters with Lithiated Epoxides
Roly J. Armstrong, Varinder K. Aggarwal*
Org. Synth. 2017, 94, 234 (DOI: 10.15227/orgsyn.094.0234)
Catalytic Enantioselective Synthesis of Atropisomeric Biaryls by a Cation-Directed O-Alkylation
John. D. Jolliffe, Roly. J. Armstrong, Martin. D. Smith*
Nat. Chem. 2017, 9, 558 (DOI: 10.1038/nchem.2710)
Cation-Directed Enantioselective N-Functionalization of Pyrroles
Roly J. Armstrong, Melissa D’Ascenzio, Martin D. Smith*
Synlett 2016, 27, 6 (DOI: 10.1055/s-0035-1560813)
Catalytic Enantioselective Synthesis of Atropisomeric Biaryls: A Cation Directed Nucleophilic Aromatic Substitution Reaction
Roly J. Armstrong, Martin D. Smith*
Angew. Chem. Int. Ed. 2014, 53, 12822 (DOI: 10.1002/anie.201408205)
Furanyl Cyclic Amines: a Diastereoselective Synthesis of 2,6-Syn-Disubstituted Piperidines Under Thermodynamic Control
Matthew O’Brien,* Andrew Leach, Roly J. Armstrong, Keting Chong, Ross Sheridan
Org. Biomol. Chem. 2012, 10, 2392 (DOI: 10.1039/C2OB07008A)