Sex is a fundamental but frequently overlooked biological characteristic of humans and model organisms that affects immune responses. We are developing integrative bioinformatics approaches to interrogate publicly available transcriptomics and epigenomics datasets to delineate the sex- determined molecular mechanisms that modulate the immune system.

We aim to generate models of the sex- and cell-specific gene regulatory networks for the major blood cell types where data is available. We will study how these sex-specific networks derived from healthy cells are influenced by infections and other disease conditions. We will develop new bioinformatics tools to integrate the sex-specific transcriptional programs with diverse sources of epigenomics information to identify the distinct chromatin configurations that underlie the different immune responses in men and women.

These results will provide the necessary framework to understand the molecular differences in men and women in response to infections, autoimmune disease and in immunodeficiencies. This will provide new insights underlying disease pathogenesis and facilitate personalised therapy for men and women.

A postdoc position funded by the Wellcome Trust is available if you will like to participate in this project! The successful candidate will the study sex-specific regulation in immune cells (data integration from publicly available transcriptomics and epigenomics databases).

Informal queries before applying are highly encouraged! Please email me if you are interested: . Click here to apply.