We explore the frontiers of pain to benefit patients
Our work crosses the disciplines of neuroscience, pharmacy, psychology, and clinical research to better understand and treat pain.
Latest news
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Emma Beecroft invited to present In Naples, Italy at the 38th International AIGeDO Congress.Â
Emma Beecroft was invited to speak in Naples, Italy, at the 38th International AIGeDO Congress on 10th October 2025. One of the core mission statements of the Italian Association for Gnathology and Orofacial Pain (AIGeDO) is to enhance practitioner expertise and patient care in this specialized field, making Emma’s invitation to present alongside eminent international…
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British Orthodontic Society ASM
Justin was invited to present at this prestigious conference (16th Oct 2024) to discuss the management of TMD and the new guidelines available to help all healthcare professionals with TMD. He also explained some of the latest science behind changes in the mouth and face, pain pathways and central brain changes. His presentation can be…
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Team present work at World Endodontic Congress in Glasgow
The team were well represented, with Professor Justin Durham, Dr Jamie Coulter, and Dr David Edwards presenting their research at the World Endodontic Congress held in in Glasgow in Sept 2024. Click here to access materials from this conference
Current projects
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ELUCIDATE: Exploring pain & autonomic dysfunction in ME/CFS & TMD
We are currently looking for people in the northeast of England with ME/CFS, Temporomandibular Disorders (TMD), or neither of these conditions to take part in this study. If you are interested in taking part, please email james.allison@newcastle.ac.uk for more information. Summary of the study Widespread pain affecting the muscles and joints is a significant problem […]
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Sarcopanc Study
Prospective longitudinal evaluation of Sarcopenia, health-related quality of life and correlation with blood and stool-based microbiome in moderately severe and severe acute pancreatitis.
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Mechanism of Spinal Cord Stimulation in the management of chronic neuropathic pain
Spinal cord stimulation (SCS) is used as a safe and effective option for multiple chronic neuropathic pain disorders. While different stimulation paradigms have been implemented into clinical practice, it remains unclear how these paradigms affect the spinal and supraspinal circuits. Evoked compound action potentials (ECAP) have been successfully used as an objective measure to quantify […]
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MiTiGate trial
MiTiGate Trial: Managing chronic Myalgia Temporomandibular Disorder: a pragmatic randomised controlled trial of Botulinum toxin type A, lidocaine, and amitriptyline/gabapentin, with internal pilot and cost-effectiveness analysis To learn more, visit the MiTiGate Trial website here: https://www.mitigatetrial.co.uk/ To self-refer to the trial, please email nuth.mitigate@nhs.net Plain English summary of the study Temporomandibular disorders (TMD) affect the […]
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Molecular Interplay in Progression of Neuropathic pain and Parkinson’s Disease.
This study aims to identify the differential gene and protein expression associated with pain pathways in iPSCs-derived sensory neurons obtained from Parkinson’s patients or patients with TSC mutations vs iPSCs controls sensory neurons using genetic and proteins analyses. Then determining the functional abnormalities in patients’ iPSC-derived sensory in response to pain stimuli by using functional […]
Our work is funded by
