We explore the frontiers of pain to benefit patients
Our work crosses the disciplines of neuroscience, pharmacy, psychology, and clinical research to better understand and treat pain.
Latest news
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British Orthodontic Society ASM
Justin was invited to present at this prestigious conference (16th Oct 2024) to discuss the management of TMD and the new guidelines available to help all healthcare professionals with TMD. He also explained some of the latest science behind changes in the mouth and face, pain pathways and central brain changes. His presentation can be…
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Team present work at World Endodontic Congress in Glasgow
The team were well represented, with Professor Justin Durham, Dr Jamie Coulter, and Dr David Edwards presenting their research at the World Endodontic Congress held in in Glasgow in Sept 2024. Click here to access materials from this conference
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James Allison’s invited presentation at EAOPD in Brussels
James was invited to speak at the European Academy of Orofacial Pain and Dysfunction in Brussles in August 2024, on temporomandibular disorders (TMD), fatigue, and the autonomic nervous system. Click here for the materials from this conference. This area of research formed the background to the ongoing Elucidate study which looks at pain in TMD…
Current projects
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MiTiGate trial
MiTiGate Trial: Managing chronic Myalgia Temporomandibular Disorder: a pragmatic randomised controlled trial of Botulinum toxin type A, lidocaine, and amitriptyline/gabapentin, with internal pilot and cost-effectiveness analysis To self-refer to the trial, please email nuth.mitigate@nhs.net Plain English summary of the study Temporomandibular disorders (TMD) affect the jaw joint and its muscles in 1 in 15 people. […]
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Seeking treatment for painful TMD
The experience of jaw pain that lasts for more than a few months can be an uncertain experience both for patients and professionals. Management may fall between the roles of dentist or GP and many people are unclear about who to consult. Self-management is recommended as first-line treatment, possibly alongside other conservative options. In practice […]
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Mediators and moderators of change following attendance at a Pain Management Programme
This study proposed an updated cognitive-behavioural model of persistent pain. Predicted relationships between variables informed by the model will be tested using multiple regression analyses, advancing our understanding of how psychological factors can be successfully targeted to improve clinical management of persistent pain.
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OldPain2Go
A randomised pilot virtual feasibility study for a virtual randomized control trial of a novel brief intervention for people with low back pain.
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Investigating the role of the histamine system in chronic pain
Histamine, acting through all four types of histamine H1-H4 receptors, is arguably the most pleiotropic molecule in the human body. Since the cloning of H3R in 1999, there has been an increased interest within the pharmaceutical industry to discover and develop ligands to this receptor to target several diseases including neuropathic pain. However, while evidence […]
Our work is funded by
