We explore the frontiers of pain to benefit patients
Our work crosses the disciplines of neuroscience, pharmacy, psychology, and clinical research to better understand and treat pain.
Latest news
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British Orthodontic Society ASM
Justin was invited to present at this prestigious conference (16th Oct 2024) to discuss the management of TMD and the new guidelines available to help all healthcare professionals with TMD. He also explained some of the latest science behind changes in the mouth and face, pain pathways and central brain changes. His presentation can be…
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Team present work at World Endodontic Congress in Glasgow
The team were well represented, with Professor Justin Durham, Dr Jamie Coulter, and Dr David Edwards presenting their research at the World Endodontic Congress held in in Glasgow in Sept 2024. Click here to access materials from this conference
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James Allison’s invited presentation at EAOPD in Brussels
James was invited to speak at the European Academy of Orofacial Pain and Dysfunction in Brussles in August 2024, on temporomandibular disorders (TMD), fatigue, and the autonomic nervous system. Click here for the materials from this conference. This area of research formed the background to the ongoing Elucidate study which looks at pain in TMD…
Current projects
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Mechanism of Spinal Cord Stimulation in the management of chronic neuropathic pain
Spinal cord stimulation (SCS) is used as a safe and effective option for multiple chronic neuropathic pain disorders. While different stimulation paradigms have been implemented into clinical practice, it remains unclear how these paradigms affect the spinal and supraspinal circuits. Evoked compound action potentials (ECAP) have been successfully used as an objective measure to quantify […]
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Mediators and moderators of change following attendance at a Pain Management Programme
This study proposed an updated cognitive-behavioural model of persistent pain. Predicted relationships between variables informed by the model will be tested using multiple regression analyses, advancing our understanding of how psychological factors can be successfully targeted to improve clinical management of persistent pain.
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Investigating the role of the kynurenine pathway in irreversible pulpitis
The kynurenine pathway is responsible for the catabolism of the essential amino acid kynurenine. This pathway has been linked to acute and chronic pain in animal models of viral infections. Research by the team has shown upregulation of this pathway in pulpititis (toothache) and it appears to be pushing the pathway towards neuroinflammation and pain. […]
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OldPain2Go
A randomised pilot virtual feasibility study for a virtual randomized control trial of a novel brief intervention for people with low back pain.
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ELUCIDATE: Exploring pain & autonomic dysfunction in ME/CFS & TMD
We are currently looking for people in the northeast of England with ME/CFS, Temporomandibular Disorders (TMD), or neither of these conditions to take part in this study. If you are interested in taking part, please email james.allison@newcastle.ac.uk for more information. Summary of the study Widespread pain affecting the muscles and joints is a significant problem […]
Our work is funded by
