Spinal cord stimulation (SCS) is used as a safe and effective option for multiple chronic neuropathic pain disorders. While different stimulation paradigms have been implemented into clinical practice, it remains unclear how these paradigms affect the spinal and supraspinal circuits. Evoked compound action potentials (ECAP) have been successfully used as an objective measure to quantify the effect of SCS in terms of neural activation of dorsal column fibres, as they represent the summation of action potentials generated from the activated fibres. ECAP recordings allow us to optimize SCS treatment by applying stimulation parameters in a consistent and controlled manner, and to investigate their effects on neural responses and SCS-induced pain relief.
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Mechanism of Spinal Cord Stimulation in the management of chronic neuropathic pain
