Research in the McAllister group focuses developing methods to produce glycopeptides and glycoproteins (i.e. peptides and proteins modified with carbohydrates), to investigate the roles of these fundamental biological molecules. Carbohydrates are involved in many important biological processes across all Kingdoms of life including how organisms recognise pathogens, how cancers can spread and the basis of the different A/B/O blood groups in humans.

We have an interest in enzymes that modify proteins with glycans, particularly O-GalNAc* glycans, and developing approaches to produce proteins with authentic glycosylation patterns. A current PhD student is investigating which proteins are modified by particular GalNAc-transferases.

Another area of investigation is carbohydrate-mediated host-pathogen interactions and we also have a PhD student working towards targeting these as a novel form of pest control in crop species.

We use a variety of chemical biology approaches techniques including recombinant protein expression, in vitro protein synthesis, solid-phase peptide synthesis, in vitro assays, biophysics and synthetic chemistry.

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PhD studentship available

Fully funded PhD studentship available starting in Sept 2024 in collaboration with Prof Claire Eyers at Liverpool investigating protein post-tranlsational modifcations. This chemical biology project will use a combination of synthetic and peptide chemistry, high-throughput substrate screening and mass spectrometry. Funded through the BBSRC NLD DTP. Contact Tom for informal enquiries.
Details of how to apply here: Deadline: 15th January 2024.

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Funding Awarded

We’re delighted to annouce we have received additional funding from the Royal Society to support a multi-year postdoctoral researcher position. Job advert coming soon!

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PhD position available

We have a fully funded PhD studentship available through the MoSMed CDT, to investigate the molecular mechanisms of prostate tumor growth driven by the protein GalNAc transferase, GalNAc-T7. Starting in September 2023, this project is in collaboration with the Munkley group at Newcastle. Deadline for applications 19th June 2023. Link

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