Current projects
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Investigating the role of the histamine system in chronic pain
Histamine, acting through all four types of histamine H1-H4 receptors, is arguably the most pleiotropic molecule in the human body. Since the cloning of H3R in 1999, there has been an increased interest within the pharmaceutical industry to discover and develop ligands to this receptor to target several diseases including neuropathic pain. However, while evidence…
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Mechanism of Spinal Cord Stimulation in the management of chronic neuropathic pain
Spinal cord stimulation (SCS) is used as a safe and effective option for multiple chronic neuropathic pain disorders. While different stimulation paradigms have been implemented into clinical practice, it remains unclear how these paradigms affect the spinal and supraspinal circuits. Evoked compound action potentials (ECAP) have been successfully used as an objective measure to quantify…
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Sarcopanc Study
Prospective longitudinal evaluation of Sarcopenia, health-related quality of life and correlation with blood and stool-based microbiome in moderately severe and severe acute pancreatitis.
Our Research Themes
Mechanisms and pathways of pain
Our work aims to understand how and why acute and persistent pain is experienced in painful conditions such as toothache, persistent facial pain, and neuropathic pain.
Pain therapeutics and clinical trials
In this research theme, our work explores new targets to treat painful conditions and assesses the efficacy, safety, and cost-effectiveness of clinical treatments.
Pain diagnostics
This work aims to improve on the current methods that clinicians have to diagnose pain conditions, and to measure and assess people’s experience of pain.
Applied pain research
Our research uses innovative clinical research, integrating multidisciplinary perspectives, to explore how best to help people who suffer from painful conditions.
Our Collaborators
Academic collaborators
- Osaka University, Japan
- University of Minnesota, MN, USA
- Aarhus University, Denmark
- University of Liverpool, UK
- University of Sheffield, UK
- University of Leeds, UK
- University of Manchester, UK
- Durham University, UK
Industrial collaborators
- Companies in the pharmaceutical and medical device sectors