Current projects
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Investigating the role of the histamine system in chronic pain
Histamine, acting through all four types of histamine H1-H4 receptors, is arguably the most pleiotropic molecule in the human body. Since the cloning of H3R in 1999, there has been an increased interest within the pharmaceutical industry to discover and develop ligands to this receptor to target several diseases including neuropathic pain. However, while evidence…
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Mediators and moderators of change following attendance at a Pain Management Programme
This study proposed an updated cognitive-behavioural model of persistent pain. Predicted relationships between variables informed by the model will be tested using multiple regression analyses, advancing our understanding of how psychological factors can be successfully targeted to improve clinical management of persistent pain.
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Seeking treatment for painful TMD
The experience of jaw pain that lasts for more than a few months can be an uncertain experience both for patients and professionals. Management may fall between the roles of dentist or GP and many people are unclear about who to consult. Self-management is recommended as first-line treatment, possibly alongside other conservative options. In practice…
Our Research Themes
Mechanisms and pathways of pain
Our work aims to understand how and why acute and persistent pain is experienced in painful conditions such as toothache, persistent facial pain, and neuropathic pain.
Pain therapeutics and clinical trials
In this research theme, our work explores new targets to treat painful conditions and assesses the efficacy, safety, and cost-effectiveness of clinical treatments.
Pain diagnostics
This work aims to improve on the current methods that clinicians have to diagnose pain conditions, and to measure and assess people’s experience of pain.
Applied pain research
Our research uses innovative clinical research, integrating multidisciplinary perspectives, to explore how best to help people who suffer from painful conditions.
Our Collaborators
Academic collaborators
- Osaka University, Japan
- University of Minnesota, MN, USA
- Aarhus University, Denmark
- University of Liverpool, UK
- University of Sheffield, UK
- University of Leeds, UK
- University of Manchester, UK
- Durham University, UK
Industrial collaborators
- Companies in the pharmaceutical and medical device sectors