Our Research

Opportunities to be involved in research

The following studies are actively recruiting participants:

MiTiGate Trial

Elucidate Study

Current projects

  • Sarcopanc Study

    Prospective longitudinal evaluation of Sarcopenia, health-related quality of life and correlation with blood and stool-based microbiome in moderately severe and severe acute pancreatitis.

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  • MiTiGate trial

    MiTiGate trial

    MiTiGate Trial: Managing chronic Myalgia Temporomandibular Disorder: a pragmatic randomised controlled trial of Botulinum toxin type A, lidocaine, and amitriptyline/gabapentin, with internal pilot and cost-effectiveness analysis To self-refer to the trial, please email nuth.mitigate@nhs.net Plain English summary of the study Temporomandibular disorders (TMD) affect the jaw joint and its muscles in 1 in 15 people.…

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  • Mechanism of Spinal Cord Stimulation in the management of chronic neuropathic pain

    Mechanism of Spinal Cord Stimulation in the management of chronic neuropathic pain

    Spinal cord stimulation (SCS) is used as a safe and effective option for multiple chronic neuropathic pain disorders. While different stimulation paradigms have been implemented into clinical practice, it remains unclear how these paradigms affect the spinal and supraspinal circuits. Evoked compound action potentials (ECAP) have been successfully used as an objective measure to quantify…

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See all research projects

Our Research Themes

Mechanisms and pathways of pain

Our work aims to understand how and why acute and persistent pain is experienced in painful conditions such as toothache, persistent facial pain, and neuropathic pain.

Pain therapeutics and clinical trials

In this research theme, our work explores new targets to treat painful conditions and assesses the efficacy, safety, and cost-effectiveness of clinical treatments.

Pain diagnostics

This work aims to improve on the current methods that clinicians have to diagnose pain conditions, and to measure and assess people’s experience of pain.

Applied pain research

Our research uses innovative clinical research, integrating multidisciplinary perspectives, to explore how best to help people who suffer from painful conditions.

Our Collaborators

Academic collaborators
  • Osaka University, Japan
  • University of Minnesota, MN, USA
  • Aarhus University, Denmark
  • University of Liverpool, UK
  • University of Sheffield, UK
  • University of Leeds, UK
  • University of Manchester, UK
  • Durham University, UK
Industrial collaborators

We work with several companies in the pharmaceutical and medical device sectors.