Publications

Peer reviewed publications and preprints

  1. Colangelo C, Antón-Fernández A, Alonso Nanclares L, DeFelipe J, Muñoz A, Ramaswamy S*. Quantitative light microscopic organization of the neuropil in the hindlimb representation of the developing rat somatosensory cortex (2021). bioRxiv. * Senior author
  2. Mei J, Muller E, and Ramaswamy S*. Informing deep learning from multi-scale principles of neuromodulatory systems (2021). In final revision at Trends in Neurosciences. * Senior author
  3. Amsalem O, King J, Ramaswamy S, Reimann M, Muller E, Markram H, Nelken I, Segev I. Dense Computer Replica of Cortical Microcircuits Unravels Cellular Underpinnings of Auditory Surprise Response (2020). bioRxiv.
  4. Ecker A, Romani A, Sáray S, Káli S, Migliore M, Mercer A, Thomson AM, Muller E, Reimann M, Ramaswamy S*. Data-driven integration of hippocampal CA1 synapse physiology in silico (2020). Hippocampus. Chosen as the cover article. * Senior author. [Open Access – OA]
    Featured news article on EPFL’s website: https://actu.epfl.ch/news/a-step-closer-to-mapping-the-rodent-brain/
  5. Barros-Zulaica N, Rahmon J, Chindemi G, Perin R, Markram H, Muller E, Ramaswamy S*. Estimating the readily-releasable vesicle pool size at synaptic connections in the neocortex (2019). Frontiers in Synaptic Neuroscience. * Senior author. [OA]
  6. Colangelo C, Polina S, Keller D, Markram H, Ramaswamy S*. Cellular, synaptic and network effects of acetylcholine in the neocortex (2019). Frontiers in Neural Circuits. Featured as Frontiers in Neural Circuits – Editors’ Pick 2021. * Senior author. [OA]
  7. Muddapu VR, Mandali A, Chakravarthy SV, Ramaswamy S*. A computational model of loss of dopaminergic cells in Parkinson’s disease due to glutamate-induced excitotoxicity (2019). Frontiers in Neural Circuits. Featured as Frontiers in Neural Circuits – Editors’ Pick 2021. * Senior author. [OA]
  8. Kanari L, Ramaswamy S, Shi Y*, Morand S, Meystre J, Perin R, Abdellah Y, Wang Y, Hess K, and Markram H. Objective morphological classification of neocortical pyramidal cells (2019). Cerebral Cortex. Chosen as the cover article. * Co-first author. [OA]
  9. Ramaswamy S, Colangelo C, and Markram H. Data-driven modelling of cholinergic modulation of neural microcircuits: bridging neurons, synapses, and network states (2018). Frontiers in Neural Circuits [OA]
  10. Ramaswamy S. Unique Maturation Trajectories of Parvalbumin-Expressing Neurons in the Cortex (2017). The Journal of Neuroscience. [OA]
  11. Ramaswamy S, Colangelo C and Muller E. Distinct Activity Profiles of Somatostatin-expressing Interneurons in the Neocortex (2017). Frontiers in Cellular Neuroscience. [OA]
  12. Reimann MW, Ramaswamy S, Horlemann A, Muller E, Markram H (2017). Morphological Diversity Strongly Constrains Synaptic Connectivity and Plasticity. Cerebral Cortex. [OA]
  13. Gal E, London M, Ramaswamy S, Globerson A, Reimann MW, Muller E, Markram H, Segev I. Rich cell-type-specific network topology in neocortical microcircuitry (2017). Nature Neuroscience. doi:10.1038/nn.4576.
  14. Rössert C, Pozzorini C, Chindemi G, Davison AP, Eroe C, King J, Newton TH, Nolte M, Ramaswamy S, Reimann MW, Gewaltig MO, Gerstner W, Markram H, Segev I, Muller E. Automated point-neuron simplification of data-driven microcircuit models (2016). arXiv preprint arXiv:1604.00087. Note: Authors are listed in the alphabetical order. [OA]
  15. Markram H, Muller E, Ramaswamy S, Reimann MW et al. (2015) Reconstruction and simulation of neocortical microcircuitry. Cell 163:456–492. * Co-first author. Chosen as the cover article. Listed in “Best of Cell 2015”. [OA]
    Opinion pieces on this work were published in:
    • Christof Koch and Michael Buice. A Biological Imitation Game (2015). Cell 163:277-280
    • Nature doi:10.1038/nature.2015.18536
    • Science doi: 10.1126/science.aad4693
    • Nature Reviews Neuroscience doi:10.1038/nrn4060
    • Nature Methods 12(12):1115
  16. Ramaswamy S, Courcol JD, M. Abdellah, S.R. Adaszewski, N. Antille, S. Arsever, G. Atenekeng, A. Bilgili, Y. Brukau, A. Chalimourda, G. Chindemi, F. Delalondre, R. Dumusc, S. Eilemann, M.E. Gevaert, P. Gleeson, J.W. Graham, J.B. Hernando, L. Kanari, Y. Katkov, D. Keller, J.G. King, R. Ranjan, M.W. Reimann, C. Rössert, Y. Shi, J.C. Shillcock, M. Telefont, W. Van Geit, J.V. Diaz, R. Walker, Y. Wang, S.M. Zaninetta, J. DeFelipe, S.L. Hill, J. Muller, I. Segev, F. Schürmann, E.B. Muller, and H. Markram. (2015) The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex. Frontiers in Neural Circuits 9. * Co-first author. Listed among the top 100 most read papers in Frontiers in 2015.
    Opinion pieces on the NMC portal were published in:
    • Christof Koch and Michael Buice. A Biological Imitation Game (2015). Cell 163:277-280
    • Nature doi:10.1038/nature.2015.18536
    • Science doi: 10.1126/science.aad4693
    • Nature Reviews Neuroscience doi:10.1038/nrn4060
    • Nature Methods 12(12):1115
  17. Ramaswamy S, and Markram H. Anatomy and Physiology of the thick-tufted layer 5 pyramidal neuron (2015). Frontiers in Cellular Neuroscience 9:233. [OA]
  18. Ramaswamy S, and Muller E. Cell-type specific modulation of neocortical UP and DOWN states (2015). Frontiers in Cellular Neuroscience 9:370. [OA]
  19. Ramaswamy S. Exciting times for inhibition: GABAergic synaptic transmission in dentate gyrus interneuron networks (2015). Frontiers in Neural Circuits. 9:13. [OA]
  20. Reimann MW, King JG, Muller EB, Ramaswamy S, Markram H (2015) An Algorithm to Predict the Connectome of Neural Microcircuits (2015). Frontiers in Computational Neuroscience 9:120. Listed among the top 100 most read papers in Frontiers in 2015. [OA]
  21. Ramaswamy S, Hill SL, King JG, Schürmann F, Wang Y and H. Markram. Intrinsic Morphological Diversity of Thick-tufted Layer 5 Pyramidal Neurons Ensures Robust and Invariant Properties of in silico Synaptic Connections (2012). The Journal of Physiology, 590, 737-752. Listed as “Editor’s Choice”, The Journal of Physiology. Vol. 590, Issue 4, Feb. 2012. [OA]
    Opinion pieces on this work were published in:
    • G.A. Ascoli. Potential connectomics complements the endeavour of ‘no synapse left behind’ in the cortex (2012). The Journal of Physiology. 590.4:651-652
  22. Ranjan R, Khazen G, Gambazzi L, Ramaswamy S, Schürmann F, Hill SL, and Markram H. Channelpedia – an integrative and interactive database for ion channels (2011). Frontiers in Neuroinformatics. 5:36. [OA]
  23. Ramaswamy S, Hill SL, Ranjan R, Druckmann S, Gidon A, Bao J, Riachi I, Schürmann F, and Markram H. The Blue Brain Project: calibrating the neocortical column (2007). BMC Neuroscience. 8: P110. * Co-first author. [OA]
  24. Ramaswamy S, Baroni F, Varona P, and De Polavieja GG. Time-scales in the interplay between calcium and voltage dynamics (2007). Neurocomputing 70 (10-12), 1949-1953. [OA]
  25. Ramaswamy S, Kiran BV, Kashyap H, and Shenoy UJ. Classification of power system transients using wavelet transforms and probabilistic neural networks (2003). IEEE TENCON 4, 1272-1276. [OA]

Granted Patents

  1. Markram H, Ramaswamy S, Muller EB, Hill S, Schürmann F (2017). Reconstruction and simulation of neocortical microcircuitry. United States Patent US 15,728,614.
  2. Reimann MW, Ramaswamy S, Markram H, Schürmann F, Muller EB, Hill SL, King JG (2015). Structural to functional synaptic conversion. United States Patent US 9,165,244.

Book Chapters

  1. Ramaswamy S, Muller EB, Reimann MW, and Markram H. Microcircuitry of the Neocortex. Handbook of Brain Microcircuits (second edition), 2017, Eds. Gordon Shepherd and Sten Grillner. Oxford University Press, UK.

Theses

  1. Ramaswamy S. Emergent Properties of in silico Synaptic Transmission in a Model of the Rat Neocortical Column (2011). PhD. thesis, Thèse EPFL, no. 5208.
  2. Ramaswamy S. The Loss of Mains Problem in Power Islanding (2004). Master’s thesis, Department of Electronic and Electrical Engineering. Department of Electrical and Electronic Engineering, The University of Strathclyde.

Conference Proceedings (More than 50 contributing talks and posters in international scientific conferences. Only selected first and last-author abstracts since 2012 are shown.)

  1. Colangelo C, Khubieh A, Markram H, and Ramaswamy S (2018). Acetylcholine regulates redistribution of synaptic efficacy in neocortical microcircuitry. Abstracts, Society for Neuroscience 2018, San Diego.
  2. Ramaswamy S, King JG, Muller E, Rahmon J, Reimann MW, and Markram H. Reconstructing cell-type specific synaptic anatomy and physiology in the neocortical microcircuit (2017). Gordon Research Conference in Dendrites, Tuscany, Italy. 
  3. Ramaswamy S, King JG, Reimann MW, Muller E, and Markram H. Network State-Dependence of Synaptic Transmission in Neocortical Microcircuitry (2016). Abstracts, Society for Neuroscience 2016, San Diego.
  4. Ramaswamy S, King JG, Muller E, Reimann MW, Segev I, and Markram H. In silico synaptic anatomy and physiology in a digital reconstruction of neocortical microcircuitry (2016). Gordon Research Conference in Synaptic Transmission, Waterville Valley NH, USA.
  5. Ramaswamy S, Muller E, Courcol JD, Van Geit W, DeFelipe J, Segev I, and Markram H. The Neocortical Microcircuit Collaboration Portal: A resource for data-driven reconstruction of neuronal microcircuits (2016). Abstracts, 10th FENS Forum of Neuroscience, Copenhagen.
  6. Ramaswamy S, King JG, Muller E, Rahmon J, Reimann M, and Markram H. Predictive in silico reconstruction of cell-type specific synaptic anatomy and physiology in the neocortical microcircuit (2015). Abstracts, Society for Neuroscience 2015, Chicago.
  7. Ramaswamy S, Reimann M, Muller E, King JG, and Markram H. Predictive in silico reconstruction of input-output organization of neocortical neurons* (2014). Abstracts, Society for Neuroscience 2014, Washington DC. *Selected for a dynamic presentation among ~ 500 other submitted abstracts.
  8. Ramaswamy S, Muller E, King JG, and Markram H. The Synaptic Network in the Neocortical Microcircuit (2014). Abstracts, The Itzhak Parnas Memorial Frontiers in Synaptic Functions Conference, Jerusalem.