Haspin phosphorylates Histone H3 to create a binding site for the Chromosomal Passenger Complex (CPC) at the centromeres of chromosomes in mitosis. The CPC, which contains the kinase Aurora B, acts to prevent incorrect attachments of microtubules (grey lines) to kinetochores (grey ovals), to ensure the appropriate segregation of chromosomes during cell division.

Leave a Reply

Your email address will not be published. Required fields are marked *