Last week, I welcomed Joanna and Arun into my research team. Joanna and Arun are fourth-year MPharm students who will be working on microneedle devices for drug delivery and biomarker detection. They are the first project students to join my team since the big move to Newcastle University last year, and I look forward to working with them.
Our paper on surface-functionalised nanoparticles and their ability to adhere to or penetrate mucous membranes has been accepted and published online. I congratulate my co-authors on this well-deserved outcome, and hereby present the paper to my readers:
In the paper, we demonstrated that nanoparticles whose surfaces were functionalised differently attained the ability to either adhere to or penetrate the mucus layer in the small intestines of the rat. We postulate that the same can be true in humans. This has important applications in oral drug delivery, where the nanoparticles can be tailored to target drug delivery to the gut differently, depending on the desired drug release profile.
The paper describes a burn wound model that enables high-throughput evaluation of wound control measures. It is based on ex vivo (i.e. freshly excised) porcine skin that is both anatomically relevant and biologically responsive, and therefore superior to most in vitro models currently available.
I am glad to have contributed to this paper, and am pleased to introduce it to my readers.
I thank the MDPI editorial office for the opportunity to be part of this effort. Special thanks go to MDPI editorial staffers, Felicia and Liane, who co-ordinated much of the work. It has been a most valuable experience for me, and I look forward to more future collaborations.
Today, the first batch of polymeric microneedle arrays rolled off the production line based in the School of Pharmacy@NCL_Pharmacy. The batch includes some new microneedle designs which we have not reported on before (until now, I guess). These microneedle arrays will now be used in some exciting new projects, which hopefully I will be able to share with you in the not-so-distant future. For now, please savour these teaser images:
Some of you may already know that I recently moved to Newcastle University. In fact, I wrote a blog post about this on my first day in the new job. In that post, I promised that I would migrate the Dermal Drug Delivery & Diagnostics (4D) Laboratory blog to a new server.
The migration has begun today. This blog post represents the start of that migration.
Given my busy schedule early in the academic year, the migration is going to be a slow process if I get my priorities right. While this blog takes shape, the impatient may head to my university staff profile for much of the same information.
For a while, there’s going to be two blogs on the Internet dedicated to the 4D Laboratory — this one, and the previous one hosted by University of Brighton. I do not know when the previous one will be wiped off the Internet (frankly, I’m surprised that it is still available), but hopefully the site will be rebooted here before that happens.