Publications – Dermal Drug Delivery & Diagnostics Laboratory

Vac-and-fill: A micromoulding technique for fabricating microneedle arrays with vacuum-activated, hands-free mould-filling
Smith E, Lau WM, Abdelghany TM, Vokajlovic D, Novakovic K, Ng KW
International Journal of Pharmaceutics 2024, 650:123706. doi: 10.1016/j.ijpharm.2023.123706

A microneedle-microplate platform to detect biomarkers in the skin
Dixon RV, Lau WM, Ng KW
British Journal of Pharmacy 2022, 7(2):1164. doi: 10.5920/bjpharm.1164

Silica nanoparticles in transmucosal drug delivery
M Ways TM, Ng KW, Lau WM, Khutoryanskiy VV
Pharmaceutics 2020, 12(8):751. doi: 10.3390/pharmaceutics12080751

The diagnostic potential of microneedles in infectious diseases
Dixon RV, Lau WM, Moghimi SM, Ng KW
Precision Nanomedicine 2020, 3(4):629-640. doi: 10.33218/001c.13658

A novel versatile animal-free 3D tool for rapid low-cost assessment of immunodiagnostic microneedles
Totti S, Ng KW, Dale L, Lian G, Chen T, Velliou EG
Sensors and Actuators B: Chemical 2019, 296:126652. doi: 10.1016/j.snb.2019.126652

Poly(lactic) acid/carbon nanotube composite microneedle arrays for dermal biosensing
Skaria E, Patel BA, Flint MS, Ng KW
Analytical Chemistry 2019, 91(7):4436-4443. doi: 10.1021/acs.analchem.8b04980

The influence of oxygen and pressure on keratinocytes
Obeid KA, Williams AC, Ng KW, Lau WM
British Journal of Pharmacy 2019, 4(1):S6-S7. doi: 10.5920/bjpharm.598

Gel-based, 3D visual and colorimetric detection of a skin cancer biomarker using immunodiagnostic microneedles
Sivaharan AJ, Lau WM, Ng KW
10th APS International PharmSci Conference, Greenwich, UK. 11-13 September 2019.

Thermoreversible hydrogel-coated microneedles for dermal drug delivery
Hill-Tout JE, Covill D, Lau WM, Ng KW
10th APS International PharmSci Conference, Greenwich, UK. 11-13 September 2019.

Decoupling the effects of hyperbaric pressure and hyperoxygenation on human keratinocyte behaviour
Ng KW, Obeid KA, Williams AC, Lau WM
10th APS International PharmSci Conference, Greenwich, UK. 11-13 September 2019.

Skin biosensing and bioanalysis: what the future holds
Ng KW, Moghimi SM
Precision Nanomedicine 2018, 1(2):124-127. doi: 10.33218/prnano1(2).180709.1

A multifunctional versatile 3D melanoma model for rapid micro-needle based in situ detection of disease specific biomarkers
Totti S, Ng KW, Lian G, Chen T, Velliou EG
American Institute of Chemical Engineers Annual Meeting, Pittsburgh, PA, USA. October 2018. ISBN: 978-0-8169-1108-0

In situ melanoma biomarker detection on a novel skin cancer 3D model via immunodiagnostic microneedles
Totti S, Ng KW, Lian G, Chen T, Velliou EG
eCM Online Periodical 2018, Collection 4, TCES Conference Abstracts, pp 90.

Synthesis of thiolated, PEGylated and POZylated silica nanoparticles and evaluation of their retention on rat intestinal mucosa in vitro
M Ways TM, Lau WM, Ng KW, Khutoryanskiy VV
European Journal of Pharmaceutical Sciences 2018, 122:230-238. doi: 10.1016/j.ejps.2018.06.032

Development of a high-throughput ex-vivo burn wound model using porcine skin, and its application to evaluate new approaches to control wound infection
Alves DR, Booth SP, Scavone P, Schellenberger P, Salvage J, Dedi C, Thet N-T, Jenkins ATA, Waters R, Ng KW, Overall ADJ, Metcalfe AD, Nzakizwanayo J, Jones BV
Frontiers in Cellular and Infection Microbiology 2018, 8:196. doi: 10.3389/fcimb.2018.00196

Penetration enhancement of topical formulations
Ng KW
Pharmaceutics 2018, 10:51. doi: 10.3390/pharmaceutics10020051

A novel 3D polymeric tool for accurate screening of the performance of immunodiagnostic polymeric microneedles
Totti S, Ng KW, Lian G, Chen T, Velliou EG
Bioinspired Materials Conference, Manchester, UK. 31 August-1 September 2018.

Nanocomposite microneedle electrochemical arrays for non-invasive transdermal sensing of analytes
Skaria E, Flint MS, Patel BA, Ng KW
PittCon Conference & Expo, Chicago, IL, USA. 5-9 March 2017.

Finite and infinite dosing
Lau WM, Ng KW
Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Dragicevic N, Maibach HI (eds). Springer Berlin Heidelberg, Berlin, Heidelberg, 2017, pp 35–44. doi: 10.1007/978-3-662-53270-6_3

Towards pain-free diagnosis of skin diseases through multiplexed microneedles: biomarker extraction and detection using a highly sensitive blotting method
Ng KW, Lau WM, Williams AC
Drug Delivery and Translational Research 2015, 5(4):387–396. doi: 10.1007/s13346-015-0231-5

Synergy between chemical penetration enhancers
Ng KW, Lau WM, Williams AC
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum. Dragicevic N, Maibach HI (eds). Springer Berlin Heidelberg, Berlin, Heidelberg, 2015, pp 373–385. doi: 10.1007/978-3-662-47039-8_24

Skin deep: the basics of human skin structure and drug penetration
Ng KW, Lau WM
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Drug Manipulation Strategies and Vehicle Effects. Dragicevic N, Maibach HI (eds). Springer Berlin Heidelberg, Berlin, Heidelberg, 2015, pp 3–11. doi: 10.1007/978-3-662-45013-0_1

Metabolic profiling of children undergoing surgery for congenital heart disease
Correia GD, Ng KW, Wijeyesekera A, Gala-peralta S, Williams R, MacCarthy-Morrogh S, Jiménez B, Inwald D, Macrae D, Frost G, Holmes E, Pathan N
Critical Care Medicine 2015, 43:1467–1476. doi: 10.1097/CCM.0000000000000982

Distribution of esterase activity in porcine ear skin, and the effects of freezing and heat separation
Lau WM, Ng KW, Sakenyte K, Heard CM
International Journal of Pharmaceutics 2012, 433:10–15. doi: 10.1016/j.ijpharm.2012.04.079

Cardioprotective effects of insulin: how intensive insulin therapy may benefit cardiac surgery patients
Ng KW, Allen ML, Desai A, Macrae D, Pathan N Circulation 2012, 125:721–728. doi: 10.1161/CIRCULATIONAHA.111.063784

Intestinal injury and endotoxemia in children undergoing surgery for congenital heart disease
Pathan N, Burmester M, Adamovic T, Berk M, Ng KW, Betts H, Macrae D, Waddell S, Paul-Clark M, Nuamah R, Mein C, Levin M, Montana G, Mitchell JA
American Journal of Respiratory and Critical Care Medicine 2011, 184:1261–1269. doi: 10.1164/rccm.201104-0715OC

Immune dysregulation in children undergoing surgery for congenital heart disease is marked by altered antigen sensing capability
Ng KW, Greco M, Allen M, Desai A, Macrae D, Bacon S, Gevers E, Inwald D, Pathan N
Critical Care Medicine 2011, 39:36. doi: 10.1097/01.ccm.0000408627.24229.88

Therapeutic and cytotoxic effects of the novel antipsoriasis codrug, naproxyl–dithranol, on HaCaT cells
Lau WM, Ng KW, White AW, Heard CM
Molecular Pharmaceutics 2011, 8:2398–2407. doi: 10.1021/mp200327k

Biodegradable microneedles for intra-epidermal vaccination
Ng KW, Pearton M, Allender CJ, Morrissey A, McLoughlin P, Birchall JC
Journal of Pharmacy and Pharmacology 2010, 62(6):798. doi: 10.1211/jpp.62.06.0016

Development of an ex vivo human skin model for intradermal vaccination: tissue viability and Langerhans cell behaviour
Ng KW, Pearton M, Coulman S, Anstey A, Gateley C, Morrissey A, Allender C, Birchall J
Vaccine 2009, 27:5948–5955. doi: 10.1016/j.vaccine.2009.07.088

Ex vivo immunological studies using excised human skin
Ng KW, Pearton M, Coulman S, Anstey AV, Gateley C, Morrissey A, Allender CJ, Birchall JC
British Journal of Dermatology 2009, 160(4):921.

Tissue viability and Langerhans cell behaviour in an ex-vivo human skin model for cutaneous DNA vaccination
Ng KW, Pearton M, Coulman S, Anstey A, Gateley C, Morrissey A, O’Mahony C, Allender C, Birchall J
Journal of Pharmacy and Pharmacology 2009, 61:A2-A3. doi: 10.1211/002235709789037044

Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies
Khan A, Benboubetra M, Sayyed PZ, Ng KW, Fox S, Beck G, Benter IF, Akhtar S
Journal of Drug Targeting 2004, 12:393–404. doi: 10.1080/10611860400003858