Our latest report exploring benzothiazolium salts as reagents for organofluorine chemistry is out now in the Beilstein Journal of Organic Chemistry! In this work, BT-SCF3 and related longer chain BT-SRF reagents were employed to efficiently convert carboxylic acids in acyl fluorides, which could then be reacted further to form amides.
Congratulations to joint first authors Lili and Alex, as well as to MChem student Rory!
Check out their work here.
Many congratulations to Lili for being awarded a runner-up prize for her talk at the 22nd RSC Fluorine Interest Group Postgraduate Meeting in Newcastle!
Lili was presenting her recent work on radical trifluoromethoxylation reactions using bis(trifluoromethyl)peroxide (BTMP). Check out her work here.
C-F Insertion reactions have many attractive features but, until recently, they have been seldom reported as methods for preparing fluorinated molecules. In our latest Concept paper in Chemistry – A European Journal, Arushi and Alex highlight the recent breakthroughs in this area and discuss the underlying strategies that can allow for successful C-F insertion processes.
Check out the paper here.
We are delighted to introduce our latest work together with the Riedel Group at the FU Berlin published in Angewandte Chemie. In this work, we report trifluoromethoxylation reactions of silyl enol ethers and allyl silanes using bis(trifluoromethyl)peroxide (BTMP) as a practical and comparatively atom economical OCF3 source. These methods deliver can provide α-(trifluoromethoxy)ketones or trfluoromethoxy-substituted alkenes depending on the reaction conditions and proceed without a catalyst or light activation.
Congratulations to Lili and all the other contributors!
To check out the paper, click here.
Our latest application of BT-Reagents is now out in the Journal of Fluorine Chemistry. In this work, we investigated benzothiazolium salts featuring long chain perfluoroalkylthio substituents as reagents for deoxygenative functionalisation reactions of carboxylic acids. This allowed for the synthesis of underexplored perfluoroalkyl thioesters directly from unactivated precursors.
Congratulations to Alex, Matteo and Haoyue!
The paper forms part of a special issue in honour of Prof. Dr. Beate Koksch in recognition of her award of the 2021 ACS Award for Creativity in Fluorine Chemistry.
Check out the paper here.
We are delighted to introduce our latest paper just published in Angewandte Chemie!
In this work, we developed a new method for conducting underexplored C-F insertion reactions using hexafluoroisopropanol as a hydrogen bond donor. This project results from our involvement in the DFG-funded collaborative research centre on “Fluorine-Specific Interactions” (SFB1349).
Many congratulations to the first author Arushi as well as Nils and the whole team!
Check out the paper here
Our latest study on Photo-NHC catalysis has been published in Chemical Science. This work was conducted in collaboration with the group of Dr. Jan Götze at the FU Berlin and explores the mechanistic features of the NHC-catalyzed PEDA reaction between acid fluorides and trifluoroacetophenone dienophiles using TD-DFT.
Many congratulations to Andreas, Manish and the whole team!
For information, check out the paper here: https://pubs.rsc.org/en/content/articlelanding/2023/sc/d2sc04732b
Many congratulations to Matteo Tironi, who successfully defended his thesis and became the second doctor to graduate from our group.
Our latest application of BT-reagents as nucleophilic reagents for organofluorine chemistry has been published in Eur. J. Org. Chem. This work reports unprecedented nucleophilic substitution reactions of alcohols –SCF2H anions generated from BT-SCF2H. The presence of the silver salt AgOTf as a catalyst is crucial for stabilising this otherwise unstable anion.
Congratulations to first author Matteo!
For information, check out the paper here: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202101557
Congratulations Lili for winning a poster prize at the 20th RSC Fluorine Subject Group postgraduate meeting! Lili’s poster presented her work using BT-SCF3 as a practical reagent for preparing (trifluoromethyl)thioesters and for activation of THF.
