All posts by Katarzyna

Merry Christmas!

Merry Christmas from the Pirog and Briggs labs!

2024 was a very good year with plenty to celebrate. Fran completed her project and generated lots of exciting data (watch this space for updates), Rachel successfully defended her PhD thesis (which we are now writing up into a paper!), Marc finished in the lab and started writing up his thesis, Anna generated a great set of preliminary data in the first year of her PhD, Gemma graduated from her MRes with a distinction, Maria made first great discoveries in her project, and Roufaida completed two secondments (one in Padova and one in Pavia) and generated data that will lead to publications and new investigation avenues. We also got MRC funding for an exciting project (led by Prof Mike Briggs and shared between Briggs, Pirog and Young labs) looking at drug repurposing for bone diseases, and we published two research papers, a book chapter and a review.

Well done everyone, and thank you very much for all your hard work and for all the fun times together. I have been very lucky to be able to work with all of you. Wishing you all a lovely Christmas break, and all the best in 2025!

The 9th edition of Genetics Matters will take place on the 2nd of March 2025

Our flagship rare disease event is back!

A fun day of science, with hands on experiments, patient and scientist talks, and an opportunity to learn and network, Genetics Matters has become a feature in the North east’s rare disease calendar. Join us on the 2nd of March to celebrate rare diseases and rare disease research in the North East, share your experiences, and find out more about rare diseases.

It’s graduations again!

A huge congratulations to all students graduating this winter, which included a few of our Skeletal Research group students from Pirog, Rice and Reynard labs. Well done everyone, and thank you for all your hard work!

And special congratulations to Gemma Farquhar who was our MRes student this year. Gemma graduated with distinction, and moved on to an exciting job with a Molecular Diagnostics group in Cambridge. Unfortunately due to the workload she couldn’t attend the ceremony today so we took this picture to send her virtual congratulations instead.

Well done Gemma, and all the best in the future from the SRG team!

We’re excited to announce a PhD position available in our lab

MRC DiMeN Doctoral Training Partnership: Investigating the role of novel motor protein in tendon development and aging.


Newcastle University    MRC DiMeN Doctoral Training Partnership

Dr K PirogDr A TwelvetreesDr EG Laird Friday, December 13, 2024 Competition Funded PhD Project (Students Worldwide)


About the Project

Musculoskeletal ageing is a multifactorial process resulting in joint stiffness and progressive tissue degeneration. This project investigates tendon ageing using tissue engineering and primary cells obtained from a mouse model of human genetic condition characterised by early-onset tendinopathy and joint degeneration. The disease, SEDMJL2, results from mutations in a novel motor protein. Although motor molecules are essential for intracellular transport of varied cargo, they remain largely unstudied in the musculoskeletal context. This project is a new collaboration between a musculoskeletal scientist (primary supervisor) and a kinesin expert (secondary supervisor), which together with the established tissue engineering collaboration (tertiary supervisor) opens up new areas of research to understand the role of kinesins in connective tissue homeostasis. We will use cells and tissues from our mouse model of SEMDJL2 coupled with in vitro and tissue engineering approaches to uncover novel molecular mechanisms of tendon repair and enhance future stem cell and tissue graft approaches. SEMDJL2 and control mesenchymal stem cells and fibroblasts will be used to study molecular pathways and to generate de novo tissues. Proliferation, apoptosis and collagen synthesis will be assessed. To study the molecular mechanisms involved in tendon ageing and repair, RNA sequencing, transmission electron microscopy (TEM) and mechanical testing will be performed on biobanked young and old mouse tendon samples and on the generated tissue engineered constructs. Tissue constructs will be subject to microdamage and their repair ability will be correlated with RNAseq data. Molecular function of the kinesin molecule in the musculoskeletal context will be studied through refining its intracellular localisation by confocal microscopy and analysis of the extracellular vesicle contents by mass spectrometry. In vitro studies of recombinant wild type and mutant protein will be used to assess its activity and motility, understand its function, and discover its binding partners.

This is an opportunity to work on a highly interdisciplinary project where a successful PhD student will receive extensive hands-on training in cell culture, tissue engineering, transcriptomics, biomechanics and biochemical assays, resulting in an exciting portfolio of highly transferrable interdisciplinary skills, and will benefit from Newcastle laboratories’ engagement in large national and international collaborative projects in which all supervisor participate and from expertise shared between Newcastle, Sheffield and Liverpool Universities.

Benefits of being in the DiMeN DTP:

This project is part of the Discovery Medicine North Doctoral Training Partnership (DiMeN DTP), a diverse community of PhD students across the North of England researching the major health problems facing the world today. Our partner institutions (Universities of Leeds, Liverpool, Newcastle, York and Sheffield) are internationally recognised as centres of research excellence and can offer you access to state-of-the-art facilities to deliver high impact research.

We are very proud of our student-centred ethos and committed to supporting you throughout your PhD. As part of the DTP, we offer bespoke training in key skills sought after in early career researchers, as well as opportunities to broaden your career horizons in a range of non-academic sectors.

Being funded by the MRC means you can access additional funding for research placements, training opportunities or internships in science policy, science communication and beyond. Further information on the programme and how to apply can be found on our website: https://www.dimen.org.uk


Funding Notes

Studentships are fully funded by the Medical Research Council (MRC) for 4yrs. Funding will cover tuition fees, stipend (£19,237 for 2024/25) and project costs. We also aim to support the most outstanding applicants from outside the UK and are able to offer a limited number of full studentships to international applicants. Please read additional guidance here: View Website

Studentships commence: 1st October 2025

Good luck!


Roufaida at the MBE 2024

Roufaida is back from a week at the CHANGE Summer School followed by Youth@MBE congress and then the main Matrix Biology Europe (MBE) meeting in beautiful Lyon.

She presented a great poster with her PhD data, had interesting scientific discussions, took part in an “omics” workshops and learnt new skills, and was part of the selection committee as a young jury member for the Youth@MBE. Well done Roufaida!

From Lyon she headed straight to the University of Pavia in Italy, where she will spent the next 3 months performing uCT analysis and zebrafish morpholino experiments. We are looking forward to the stories and results on her return 🙂