Category: Physiological Sciences

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An Insight Into Clinical Operations at Roche

by Rebecca Watson, Stage 3 Physiological Sciences

I spent my 13-month industrial placement at Roche Products Ltd., Welwyn Garden City. My role was in Global Clinical Operations as a Clinical Operations Lead (COL) based in the Product Development department. Initially, I did not know what to expect going into this huge industry to do a job that I had no expertise in but I quickly got to grips with the responsibilities of my role and began to learn more about the pharmaceutical industry.  

Roche Products Ltd

Roche is a global healthcare company, with branches in both pharmaceuticals and diagnostics, and innovative solutions across a range of different therapeutic areas. Since being founded in 1896, Roche has created a number of pharmaceutical and diagnostic solutions to help diagnose and treat a number of life threatening diseases, one such solution being Kadcyla used in the treatment of HER-2 positive breast cancer.  

The Roche Welwyn Garden City office.

Day to Day

At the beginning of my placement I was assigned to a clinical trial and began to get to know my study team, starting with regular team catch ups and having 1-1s with the members of the team to find out more about what their responsibilities were on the study and how I could help with their tasks. This helped me develop my understanding of the fundamentals of a clinical trial and gain an appreciation for the importance of Operations in ensuring the smooth running of the trial.  

Eventually I progressed to managing my own projects on the study, such as creating a weekly information bulletin for the clinics where the trial was ongoing, collating important recruitment and data information from the study systems and presenting it in an easily digestible format, highlighting the most relevant updates for the busy sites to remain informed on the progress of the trial. This had a hugely positive impact on my attention to detail and gave me the opportunity to get to grips with the study systems to get the information that I needed to create these before moving on to bigger tasks.  

Around halfway through my placement, I was given the responsibility of having oversight of the trial in 5 of the countries that we had active on the study. This was a task I had been eager to get experience in since joining the study team and proved to be a large step up, having to relay study level updates to the country COLs to keep them informed of any upcoming changes. This also involved preparing for meetings in advance, collecting any updates from team calls, data metrics reports and recruitment figures to get the most out of these meetings. Although this was challenging at times, it really helped me develop my ability to be comfortable in asking questions as I was the one responsible for finding answers. Overall this was one of my biggest achievements throughout the whole of my placement (not to mention never missing one of my 7am calls). 

The Roche Products Ltd. Welwyn Garden City office Christmas party 2023. Pictured left to right: Rebecca Watson, Paayal Shah, Jude Abou Chakra, Mehreen Haque, Jessica Patrick, Jessica Williams.

Later on in my placement, I began to get involved in work outside of Clinical Operations in Product Development, taking the opportunity to work with colleagues in Pharma Biosamples Solutions (PBS) to gain experience in the long term storage of patient samples. This was a great experience and it was a privilege to get to know the team there, who were always willing to help with any tricky requests that I received.  

The Office Community

Aside from study work on my placement, I was also very involved in the office community at Welwyn, having co-created the Roche Badminton Club with another placement student. We ran a session every Tuesday evening at a local sports hall which was open to players of all abilities across all departments. This was very well attended amongst our early in careers colleagues and even attracted some seasoned players who had been at Roche for a number of years. This was a great way to increase our visibility in the community and led to us making some valuable connections with colleagues in other departments. 

Celebrating a point at one of our Tuesday evening badminton sessions. Pictured left to right: Riyana Raja, Grace Tucker, Jude Abou Chakra.

I also enjoyed being part of the Eco-Garden committee and participating in events such as the Family and Friends Day where we ran a craft stall for colleagues and their children to decorate small garden ornaments that were then hung up in the garden. We even managed to grow a few crops over the year which were available for anyone in the office to help themselves to.  

The Eco-Garden committee and our craft stall at the Family and Friends Event 2023. Pictured left to right: Grace Tucker, Saad Bin Huda, Rebecca Watson.

A Few Final Words

To anyone contemplating doing a placement, I would 100% recommend it as it has given me not only a greater understanding of this role and industry, but also a greater appreciation for my own abilities and vastly improved my confidence for going forward into my career after university. Good luck on your applications and make the most of the year! 

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The wonderful world of Microbiology

Ever wondered what goes on in the Newcastle University Biomedical Sciences labs behind the scenes? On Wednesday 28th February, researchers from the school of Biosciences, Nutritional and Sports Sciences organised a Microbiology research fair to give students a sneak peak into the fascinating world of microbiology research, PhDs, careers, summer placements and final year projects. There were also amazing opportunities to go and see the research laboratories and facilities on the lab tours. So I couldn’t resist tagging along to see what was going on – and let me tell you, it didn’t disappoint! From chatting with researchers deep in ground-breaking projects to getting a first hand look at cutting-edge equipment, there was so much to discover.

Students were talked through different research at each station

There were many areas of research, but one big topic that caught my attention was the gut microbiome. Even though this research fair was mainly aimed at Biosciences students, it was interesting as a student dietitian myself to see the vast amount of research that the University is conducting on this area, as it is a really new and exciting area in the advancing field of nutrition. Some PhD students were researching into how fibre is broken down in the gut by different strains of gut bacteria and how the body uses these chemicals that are produced. One student was focussing particularly on how caramelised sugars are digested by the gut microbiome, and even though excess sugars are seen to have harmful effects on health, some gut bacteria can break these down to useful chemicals!

One of the most interesting stations for me was the station that was showing a machine taking species from the sea to make antibiotics. A remote machine goes down 4000m deep in the South Pacific and takes samples from the bottom of the ocean. It was fascinating how intricate the collection process was, yet how simply the machine could extract the sediment. These samples are then transported back to the labs and the microbes are cultured. The microbes of particular interest to them are Actinomycetes, and these produce 70% of all antibiotics. These actinomycetes have the ability to kill MRSA and other large strains of microbes. These researchers really had a passion for the undiscovered potential of the sea, and it seems like this is a really up and coming area of research.

Here you can see the machine arm working at the bottom of the sea floor to extract the sediment

The most exciting part of the afternoon was the tours of the research labs! From state-of-the-art equipment to cutting-edge facilities, the students got a first hand look at what goes on in the world of research. Our tour leader’s research was focussing on Staphylococcus Aureus. Yes, we are talking about the superbug MRSA – a bacteria that is very complicated as it has the potential to cause lots of different diseases.

Gel electrophoresis equipment in the laboratory
Our fab laboratory tour guide showing us her MRSA superbug cultures

The labs had loads of cool equipment – the second one we were showed around was a biochemistry lab with research focussing on proteins. Their mission is to purify tiny proteins to find the protein of interest, and then grow crystals of it. The coolest machine in the lab by far was the X ray generator, which focuses on the protein crystal. The x ray signal is then amplified and detracts using electron density, which will rotate and shoot as many x rays as possible to collect the data. This helps them to calculate the structure of the molecule with the help of computer software, therefore figuring out what the protein looks like and its function. Ever heard of the lock and key interaction? Well, imagine the protein as the lock and the target molecule as the key. With 3D printing technology, these researchers can create super cool models of the protein structure. And here’s a fun fact to wrap things up – this model below was created of a tyrosine residue. Turns out, it’s not just some fancy scientific term – it’s actually a super important ingredient that can be used in toothpaste to break down plaque in your mouth, showing how important this science research is in everyday life!

The 3D model of tyrosine residues generated by the 3D printer


Biomedical scientists are also actively involved at the Freeman Hospital in researching urinary tract infections (UTIs) through a patient-centred approach, involving collaboration with clinicians ant their patients. This approach emphasizes the importance of understanding the individual needs and experiences of patients in managing and treating UTIs. By working closely with clinicians and patients, these biomedical scientists are contributing to the development of personalized treatment strategies and interventions to improve patients outcomes. They also are conducting laboratory based research to better understand the underlying causes of UTIs, including identification of pathogens, antibiotic resistance patterns and host immune responses to help advance our understanding of them and develop more effective treatment options. This work shows the diverse scope of the Biomedical science profession, which extends beyond traditional lab-based research to the hospitals to use more patient-centred approaches to better improve quality of care.

Judith and Phillip are both active researchers within the Freeman Hospital and with Newcastle University

The research showcased at the fair provided a glimpse into the groundbreaking research happenign at the university in various fields. From the gut microbiome to exploring the potential of the sea for antibiotic discovery, students had so much opportunity to ask questions. The future of science is definitely looking bright!

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My Experience as a Year In Industry Student

By Joel Tyler, BSc Physiological Sciences

Edited by Maddie Wildridge

Reckitt is a Fast Moving Consumer Goods (FMCG) company with offices and employees spread out across the world. Founded in 1870, Reckitt started off by selling laundry starch in Hull, now, Reckitt operates in a range of markets and is the owner of various health and medicinal brands such as; Neurofen, Strepsils, Dettol, Vanish and Durex to name a few.

Examples of some Reckitt products sold around the world

My placement year was a lab-based role involved in working for the brand Veet, this included both formulation manufacturing and analytical testing for the depilatory cream products currently available to buy in shops as well as a new product being developed and to be released in the near future.

A Day in the Life

Using a Light Microscope to examine the structure of a hair sample

Due to the fast paced environment (as an FMCG company), I found that there was always something to do all the time and the days/weeks were fairly similar. This is because of the constant manufacturing of different formulations of new products to be tested under different stability conditions, and then followed by analytical testing of the formulations to identify which was the best product.

Therefore, my normal day would start with a team meeting to discuss where everyone was at with formulation/testing work and to discuss steps/processes going forward or if anything had failed/gone wrong with the batch. After, I would go to the lab to complete any formulation/analytical testing which needed to be done.

I enjoyed this working routine as it meant I gained far more lab experienced than I initially thought I would, it was always very clear what work I needed to be doing and I was always given lots of support if things ever went wrong. I would say I definitely wasn’t treated as a ‘student’ but a very integral part of the team which also surprised me!

Student Project
In the second half of my placement, I organised and created a project alongside my line manager which involved testing the tensile strength of hair using a texture analyser and a brand new test method. I also presented my results to the rest of the Veet brand to explain my findings.

Hair sample being tested in the Texture Analyser to investigate the tensile strength

During my project I had to test thousands of individual hair samples and as a result became the most experienced within the lab at using the texture analyser, this meant that I had the opportunity to present and perform samples to higher up executives within the company (and even the Global Head of R&D) which was an amazing experience.

A Becomix machine used to formulate and manufacture different depilatory creams during my placement year

Why I Chose To Do a Placement
I decided during first year of my degree that I wanted to do a placement, specifically a lab based placement, because I was enjoying being in the lab at university but I was curious if I would enjoy working in a lab as a full time job to give myself an idea for post graduate jobs.

Having completed my full year, I now know I could happily work in a lab after university, so applying for lab based roles isn’t a big risk but also that I know I can work efficiently and thrive under the environment. My placement gave me many challenges along the way (which is natural when learning new things in a short space of time) but I gained valuable and employable experience in overcoming these obstacles and realised that I feel confident within a lab setting.

I Would Highly Recommend a Placement!
Completing my placement year was definitely one of the most important things I have done within my life. The obvious reasons being all the different skills and attributes which I learnt/developed along the way, but also, the experiences which are available in just one year really surprised me, with the huge amounts of social networking needed to be done for my day to day job, I found myself naturally speaking to and shadowing other departments, creating professional relationships which will last for life. So I would say even if you are even considering to apply for placements, just go for it because you won’t regret it!

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Overview of my GSK placement year

By Lauren Wheeler, Stage 3 Biomedical Sciences

During my placement, I worked at the GSK R&D site in Stevenage as a placement student within the SPMB department (Screening, Profiling and Mechanistic Biology). SPMB works on assay development, compound profiling and mechanism of action studies.

My role involved automating a 3D hepatotoxicity assay by creating a model to validate a fully integrated platform in order to move the manual assay onto the platform, as well as running a biweekly safety screening assay.

When starting my labwork, I was supervised but I was allowed to complete the work myself which I found very beneficial as it allowed me to make mistakes which I could learn from. I found myself able to start completing my own experiments independently a lot faster than I expected to. Everyone in the lab was also very helpful and was always willing to help or answer any questions when I got stuck.

During my time at GSK, I also got to take part in many other activities alongside my project work which allowed me to gain and improve skills, to network and improve relationships with other IPs (industrial placement students) as well as other GSK employees.

Myself and some other committee members at the International Women’s Day selfie corner – names of people from left to right: Francesca Dale, Lauren Wheeler, Lydia Haines, Neve Richardson

I became a committee member of both the Women’s Leadership Initiative (WLI) and the Stevenage hub committee. With both, I worked with other IPs and members of the committee to organise events such as International Women’s Day and the employee appreciation cookie post.

I was head of logistics for International Women’s Day in which I held key responsibilities in organising attendance numbers, booking catering, setting up market stalls with other employee resource groups at GSK and setting up of the lecture theatre for the event. The event included 2 talks and a panel which were all very insightful and turned out to be a great success with many attendees. I was also rewarded a recognition award (R&R) for my contribution.

I also worked with another IP to organise the employee appreciation cookie post in which GSK employees could donate £2 to save the children which would allow them to send a cookie along with a message to another GSK employee. These were delivered by hand by us, so it was really nice to see how happy and thankful people were when receiving a cookie.

Basket of cookies labelled for each person ready to be delivered

I took part in the Tough Mudder challenge in May 2023 with around 30 other GSK employees in which we raised £350 each and completed a 15km run with 30 obstacles. This was a difficult challenge however we stuck together as a team throughout the course, and it felt like a big achievement once we completed it.

Myself and other GSK employees after finishing the Tough Mudder – names of people from left to right: Ross Biddulph, Samuel Pearson, Jake Brett, Lydia Haines, Lauren Wheeler, Francesca Dale, Neve Richardson, Rebecca Glenny

I was also a part of a netball team at GSK where we trained once a week on a Wednesday, it was a mixed team with members from across the GSK Stevenage site. We took part in a match against the Ware site, which we won as well as a charity tournament, all of which were great experiences to take part in.

During this year, I have also had the chance to take part in IP collaboration events. I attended an IP organised presentation session every 2 weeks in which IPs across different departments presented about their projects as well as discussing any issues they had been having. This was a good opportunity to network and learn more about other departments work.

Myself and some other IPs attending an IP collaboration presentation session – names of people from left to right: Neve Richardson, Lauren Wheeler, Francesca Dale

We also had a lab tour exchange with the Ware site in which I helped in touring the IPs around the labs I worked in as well as going to the Ware site for a tour. It was insightful to see the later stages of the drug development process.

Overall, this placement year has been an invaluable experience in which I have been able to learn and experience far more than I could have expected when I first joined. I have gained many new skills and have really increased my confidence. I’d highly recommend a placement at GSK! Check out their Early Career talent site here for more information.

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From One First Year Student to The Next

By: Caroline Elaine

I’ll give you a little teaser of your first year at Newcastle University if you’re planning to study at BNS school.

When I was giving the offer holders’ students a tour of the school, I noticed that some of the questions they asked were quite similar. For example, how are the lectures, what modules are we studying, and so on.

Therefore, I’ll go over some of the things I believe you should all know. Hopefully, after reading this, you have a better idea of how your first year of university will go. Okay, let’s get started! 

Continue reading “From One First Year Student to The Next”
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Partners: more than just a summer school

decorative header photo introducing foreword by Dr Damian Parry

I have been leading the Partners programme in the School of Biomedical Sciences (as it was then) since 2014 – and have enjoyed every moment.

In “normal times” it’s a great opportunity for students to come onto campus and experience university life in a “snapshot”. It’s my ideal that the experience will minimise fear of the unknown, seeing that Newcastle University’s School of Biomedical, Nutritional and Sport Sciences is a place where students can feel at home, see themselves thriving and anticipate a great 3 or 4 years ahead.

Obviously, last year and this year things have changed, and we’ve had to move the provision totally online, but hopefully there is still a chance to see what university life will be like, meet future colleagues in studies and members of staff, and get to know each other.

Continue reading “Partners: more than just a summer school”