Tag: biomed

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The wonderful world of Microbiology

Ever wondered what goes on in the Newcastle University Biomedical Sciences labs behind the scenes? On Wednesday 28th February, researchers from the school of Biosciences, Nutritional and Sports Sciences organised a Microbiology research fair to give students a sneak peak into the fascinating world of microbiology research, PhDs, careers, summer placements and final year projects. There were also amazing opportunities to go and see the research laboratories and facilities on the lab tours. So I couldn’t resist tagging along to see what was going on – and let me tell you, it didn’t disappoint! From chatting with researchers deep in ground-breaking projects to getting a first hand look at cutting-edge equipment, there was so much to discover.

Students were talked through different research at each station

There were many areas of research, but one big topic that caught my attention was the gut microbiome. Even though this research fair was mainly aimed at Biosciences students, it was interesting as a student dietitian myself to see the vast amount of research that the University is conducting on this area, as it is a really new and exciting area in the advancing field of nutrition. Some PhD students were researching into how fibre is broken down in the gut by different strains of gut bacteria and how the body uses these chemicals that are produced. One student was focussing particularly on how caramelised sugars are digested by the gut microbiome, and even though excess sugars are seen to have harmful effects on health, some gut bacteria can break these down to useful chemicals!

One of the most interesting stations for me was the station that was showing a machine taking species from the sea to make antibiotics. A remote machine goes down 4000m deep in the South Pacific and takes samples from the bottom of the ocean. It was fascinating how intricate the collection process was, yet how simply the machine could extract the sediment. These samples are then transported back to the labs and the microbes are cultured. The microbes of particular interest to them are Actinomycetes, and these produce 70% of all antibiotics. These actinomycetes have the ability to kill MRSA and other large strains of microbes. These researchers really had a passion for the undiscovered potential of the sea, and it seems like this is a really up and coming area of research.

Here you can see the machine arm working at the bottom of the sea floor to extract the sediment

The most exciting part of the afternoon was the tours of the research labs! From state-of-the-art equipment to cutting-edge facilities, the students got a first hand look at what goes on in the world of research. Our tour leader’s research was focussing on Staphylococcus Aureus. Yes, we are talking about the superbug MRSA – a bacteria that is very complicated as it has the potential to cause lots of different diseases.

Gel electrophoresis equipment in the laboratory
Our fab laboratory tour guide showing us her MRSA superbug cultures

The labs had loads of cool equipment – the second one we were showed around was a biochemistry lab with research focussing on proteins. Their mission is to purify tiny proteins to find the protein of interest, and then grow crystals of it. The coolest machine in the lab by far was the X ray generator, which focuses on the protein crystal. The x ray signal is then amplified and detracts using electron density, which will rotate and shoot as many x rays as possible to collect the data. This helps them to calculate the structure of the molecule with the help of computer software, therefore figuring out what the protein looks like and its function. Ever heard of the lock and key interaction? Well, imagine the protein as the lock and the target molecule as the key. With 3D printing technology, these researchers can create super cool models of the protein structure. And here’s a fun fact to wrap things up – this model below was created of a tyrosine residue. Turns out, it’s not just some fancy scientific term – it’s actually a super important ingredient that can be used in toothpaste to break down plaque in your mouth, showing how important this science research is in everyday life!

The 3D model of tyrosine residues generated by the 3D printer


Biomedical scientists are also actively involved at the Freeman Hospital in researching urinary tract infections (UTIs) through a patient-centred approach, involving collaboration with clinicians ant their patients. This approach emphasizes the importance of understanding the individual needs and experiences of patients in managing and treating UTIs. By working closely with clinicians and patients, these biomedical scientists are contributing to the development of personalized treatment strategies and interventions to improve patients outcomes. They also are conducting laboratory based research to better understand the underlying causes of UTIs, including identification of pathogens, antibiotic resistance patterns and host immune responses to help advance our understanding of them and develop more effective treatment options. This work shows the diverse scope of the Biomedical science profession, which extends beyond traditional lab-based research to the hospitals to use more patient-centred approaches to better improve quality of care.

Judith and Phillip are both active researchers within the Freeman Hospital and with Newcastle University

The research showcased at the fair provided a glimpse into the groundbreaking research happenign at the university in various fields. From the gut microbiome to exploring the potential of the sea for antibiotic discovery, students had so much opportunity to ask questions. The future of science is definitely looking bright!

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My placement year at Reckitt

By Joel Tyler

Reckitt is a Fast Moving Consumer Goods (FMCG) company with offices and employees spread out across the world. Founded in 1870, Reckitt started off by selling laundry starch in Hull, now, Reckitt operates in a range of markets and is the owner of various health and medicinal brands such as; Nurofen, Strepsils, Dettol, Vanish and Durex to name a few. 

Some examples of Reckitt products sold around the world. Via Google Images

My placement year was a lab-based role involved in working for the brand Veet, this included both formulation manufacturing and analytical testing for the depilatory cream products currently available to buy in shops as well as a new product being developed and to be released in the near future. 

A day in the life

Due to the fast paced environment (as an FMCG company), I found that there was always something to do all the time and the days/weeks were fairly similar. This is because of the constant manufacturing of different formulations of new products to be tested under different stability conditions, and then followed by analytical testing of the formulations to identify which was the best product.  

Using a light microscope to examine the structure of a hair sample

Therefore, my normal day would start with a team meeting to discuss where everyone was at with formulation/testing work and to discuss steps/processes going forward or if anything had failed/gone wrong with the batch. After, I would go to the lab to complete any formulation/analytical testing which needed to be done.  

I enjoyed this working routine as it meant I gained far more lab experienced than I initially thought I would, it was always very clear what work I needed to be doing and I was always given lots of support if things ever went wrong. I would say I definitely wasn’t treated as a ‘student’ but a very integral part of the team which also surprised me! 

Student Project

In the second half of my placement, I organised and created a project alongside my line manager which involved testing the tensile strength of hair using a texture analyser and a brand new test method. I also presented my results to the rest of the Veet brand to explain my findings. 

During my project I had to test thousands of individual hair samples and as a result became the most experienced within the lab at using the texture analyser, this meant that I had the opportunity to present and perform samples to higher up executives within the company (and even the Global Head of R&D) which was an amazing experience. 

Hair sample being tested in the Texture analyser to investigate the tensile
A Becomix machine used to formulate and manufacture different depilatory creams. Via Google Images

Why I chose to do a placement

I decided during first year of my degree that I wanted to do a placement, specifically a lab based placement, because I was enjoying being in the lab at university but I was curious if I would enjoy working in a lab as a full time job to give myself an idea for post graduate jobs.  

Having completed my full year, I now know I could happily work in a lab after university, so applying for lab based roles isn’t a big risk but also that I know I can work efficiently and thrive under the environment. My placement gave me many challenges along the way (which is natural when learning new things in a short space of time) but I gained valuable and employable experience in overcoming these obstacles and realised that I feel confident within a lab setting.

I would highly recommend doing a placement!

Completing my placement year was definitely one of the most important things I have done within my life. The obvious reasons being all the different skills and attributes which I learnt/developed along the way, but also, the experiences which are available in just one year really surprised me, with the huge amounts of social networking needed to be done for my day to day job, I found myself naturally speaking to and shadowing other departments, creating professional relationships which will last for life. So I would say even if you are even considering to apply for placements, just go for it because you won’t regret it! 

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A year at Pharmaron UK

By Billy James

Most, if not all of you, will have never heard of Pharmaron. Neither had I, till I applied for a placement in their Formulation Development Team. 

A little context 

I first came across Pharmaron when looking for placements back in September 2021. A lecture entitled “Drug Formulation” had sparked my interest in the first few weeks of term, so when I came across Pharmaron’s “Formulation Development” placement I applied straight away.

 In preparation for interviews I did a little research into the company and found out they were a CDMO, or contract development and manufacturing organisation. Essentially, Pharmaron take on client contracts for anything ranging from drug discovery all the way through to manufacturing drug product for clinical trials.

Two of the buildings at Pharmaron’s Hoddesdon Site

My Placement

The placement itself was a 12-month stint within the formulation development team at the company’s site in Hoddesdon (I still wouldn’t be able to point this out to you on a map!). During the year, I was exposed to and involved in much more than I expected. If, like me, you expected a year of photocopying and running errands, then think again.

I couldn’t believe how soon I was thrown in the deep end! The CDMO work environment is very dynamic, any minute a client can email in a request to change or add to a contract and then its all hands on deck to get the work done. After only a few weeks of training (and reading lots of documentation), I was straight into helping my supervisor with the production of a batch of tablets for stability testing. And that was only the start.

Some examples of things I did while on placement include: qualification of fridges, freezers and digital clocks (yes, even clocks have to qualified in a GMP environment), production of stability batches (many, many tablets and capsules), installation and set up of new automatic balances (terrifyingly expensive pieces of kit) and completing a case study for the team.

The case study

Case studies are carried out on topics the team have little experience in or to show off their expertise to potential clients.

A case study I was asked to complete while on placement looked at tablet coatings. Specifically, the team wanted to learn more about (and show clients we knew about) titanium dioxide free coatings and how they compared to regular, titanium dioxide containing coatings. I won’t bore you with the legislative details, but to make a long story short, the EU may ban this compound from tablet coatings. This would be a bad thing as it would mean many drug shortages and discontinuations, as it has many very useful properties. Other compounds with similar properties simply do not exist.

I was given free reign on how to complete the case study, which gave me a real sense of pride as the team felt confident enough in my abilities to complete this important piece of work for them. Completing the case study also gave me an excellent piece of work to write my Placement Report on.

Another opportunity which arose from completing this case study was submitting a poster and abstract to the APS (Academy of Pharmaceutical Sciences) to present at their annual PharmSci conference.

APS and PharmSci

After completing my case study and placement report, and as my placement was coming to an end, my supervisor suggested submitting an abstract and poster of my work to the APS for their PharmSci annual conference.

I thought this was an amazing opportunity which I couldn’t pass up on, so in the last few days of my placement I worked hard to prepare both a poster and abstract detailing the work we had completed on the case study.

To my surprise, both were accepted for presentation at the conference, and the abstract was also selected for an oral presentation (at the time this terrified me, but I soon realised it was an amazing opportunity)!


Attending the (all expenses paid!) conference was truly the highlight of my year, and being able to present the work I had spent many months on was an extremely proud moment.

Presenting at the APS PharmSci conference

I can’t recommend doing a placement enough, irrespective of if it involves lab work, office work or a combination of the two, it really is a fantastic and formative experience. Not only do you get paid (usually quite well!) for a year, but you also learn and are exposed to so many new things which could eventually be what you decide to do when you leave university.

If you are in two minds over doing a placement or not, take this as a sign to go for it!

You won’t regret it!

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A year in NHS labs

By Chloe Heppenstall

What goes on in the NHS laboratories? 

Rather than a research-based placement, my time in the NHS laboratories involved completing routine assays to test samples and deliver crucial patient results as soon as possible. I was part of the Immunology team within Laboratory Medicine, however there are numerous different departments, such as haematology, virology, microbiology, or chemistry. Having previously worked in the NHS as a domestic, I thought I knew a lot about what happens in the hospitals, but this placement was a huge eye opener as to how much goes on behind the scenes! 

Thank you NHS by Karolina Grabowska from Pexels

Why I applied for a placement year. 

As I was heading into my second year of University, I was developing a deep interest for Immunology, however I was unsure on what careers would involve this work, and if I would enjoy it. I figured a laboratory-based placement would be the best way for me to understand what work in this sector looks like, and if it was something that I could thrive in. From enjoying my time in the labs at university, I knew a hands on, lab-based placement would be something for me. By taking on this exciting opportunity in the Immunology laboratory in the NHS, I was able to utilise my skill set and knowledge further in an area I was keen on progressing into. 

Me wearing different PPE

What does a typical day look like? 

Each day differed depending on which bench I was allocated to. Within the department, there are 7 different benches, which a Biomedical Scientist would usually spend between 2-6 months on before rotating. These benches involve techniques such as gel electrophoresis, immunofluorescence, immunofixation, immunodisplacement, and automated and manual assays. As part of my placement, I had the opportunity to rotate around all the benches, and each bench was dissimilar to the last. Depending on turnaround times, any backlogs of samples, or any additional work the lab was taking on from other labs, one bench could be a lot busier compared to other benches, and require more staff members to help.  

Identifying monoclones via gel electrophoresis] 

What did I learn? 

In addition to utilising laboratory techniques I acquired during university, I learnt a range of new methods which I will carry as valuable experience for future job prospects. Furthermore, I learnt the importance of turnaround times, and the impact which can occur for the patient if these are not met. My professionalism also grew, as I frequently had to speak to other healthcare professionals, such as nurses in A&E, or midwives. Outside of the lab, the clinical scientists held lectures and journal club sessions, which focussed on the clinical applications and impact of the assays we were completing in the laboratory. This was useful as time in the lab can become very fast paced and repetitive, and it can be easy to forget why you are doing what you are doing. Finally, I made a lot of friends who share similar interests and hobbies to myself, which enabled me to develop a healthy work-life balance. 

Me extracting calprotectin samples in a fume cupboard

What did I find challenging? 

Although many people warned me, adjusting to the 9-5 working life was extremely difficult. Despite my day finishing at 5 and having my weekends off, I have been just as tired working 9-5 than I was at university with loads of deadlines! On the other hand, there was no stress like there is with university, and if I ever had any problems with work, or I did not understand a concept, the team in Immunology were so welcoming and would give me as much time as I needed to understand and complete something. 

Would I recommend a placement to other students? 

Absolutely. The skills and experience you acquire whilst on a placement are invaluable, and put you in the best position for applying to jobs after university. If you are seeking hands on experience and a taste of the real world outside of university, do not hesitate to apply to placement opportunities! Aside from the unique skillset I have acquired, I have also been given opportunities to meet new people and discuss their opinions on interesting real-life assay topics, and my potential career in the NHS. I feel confident in a laboratory workplace, which is something I never thought I would be saying! 

I now cannot wait to complete my final year at university, obtain my degree, and take my skillset further either in postgraduate studies or in a job. 

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Would your blood glow?

By Sarah Holder

The Beginning 

All the way back at the start of my second year at Newcastle University, the thought of a placement year was a nice one, but I never thought I’d be one of the lucky few to be offered one! When I came across the advert for the job at Labcorp Huntingdon, I knew it would be the only intern position I wanted to apply for. The role sounded perfect and it was located only half an hour from my home village. I sent off my initial application and then received an invite for an interview! And then another! And another! I couldn’t believe it when I received a phone call in January to say I had been offered the intern position for Immunology and Immunotoxicology 2022-2023. Brilliant! 

Background to my Project 

Human blood is made up of several major components including plasma, platelets, red blood cells and white blood cells. White blood cells are involved in the body’s response to infection and need to be tested separately to the rest of the blood components to see the best results.  

Via Giphy.

Infections can come in the form of viruses or bacteria. Viruses present markers called epitopes on their surface which the white blood cells use to identify what they are. Bacteria don’t directly present these epitopes but via white blood cells they infect which present their epitopes for them. When these epitopes are come across in the bloodstream, specific white blood cells release chemicals called cytokines to activate the immune response and fight the infection. We were adding epitopes artificially in the form of our stimulants to elicit a response from six different human donors and judge the stimulant that gives the clearest response across the six blood samples.   

My Project 

My project during my time on placement at Labcorp had two parts. Improving the white blood cell isolation method and investigating white blood cell responses to positive controls we added to them and attaching fluorescent green and red markers to the different cytokines produced. We had longer to plan my project than expected so it didn’t get into the lab until May, creating more pressure for everything to go smoothly once it was underway. If anything had gone drastically wrong, we wouldn’t have had enough time to order the reagents required for another attempt. The images taken at the end were full of fluorescent spots so the project worked! 

Via Giphy

My project has provided a future method for FluoroSpot assays to be carried out at Labcorp on our Huntingdon site which will hopefully be able to bring more revenue into I&I. Future research into the method we developed for my project could be done to optimise it further and make it a more streamlined process. 

Life on Placement 

I was lucky enough to not only secure a placement but secure a placement I could commute to from my home. Thankfully, my parents were happy to have me back for another year! While the 6:45am wakeup call wasn’t my favourite, I could spend my evenings visiting my friends from home, which was lovely. I worked a mixture of 8am-4pm and 8:30am-4:30pm throughout the week and it was nice actually being able to catch a glimpse of daylight in the winter when leaving at 4pm instead of both arriving and leaving in what feels like the dead of night every day. 

Every month a department social was held by the I&I Social Committee. My favourites were the Halloween bar crawl, Christmas party and lab getaway weekend to a lakeside cabin with the team.  These really helped me to feel part of the team during my time working at Labcorp. 

Via Giphy

Summary 

I would really recommend a placement year to anyone considering one, the lab experience gained is a perfect CV addition for life after university and the additional skills of working in a team and independently while in an industry setting are invaluable. I was very fortunate and had the best line manager in terms of supporting my transition into a working environment, this was aided massively by the chocolate that magically appeared on my desk every Friday. I’m not sure what my future after university is going to be yet, but thanks to my placement year I know I can join a workplace and adapt to fit in very quickly, and training can be provided if I feel I have any gaps in my knowledge for my future role. No question is a stupid question! 

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From One First Year Student to The Next

By: Caroline Elaine

I’ll give you a little teaser of your first year at Newcastle University if you’re planning to study at BNS school.

When I was giving the offer holders’ students a tour of the school, I noticed that some of the questions they asked were quite similar. For example, how are the lectures, what modules are we studying, and so on.

Therefore, I’ll go over some of the things I believe you should all know. Hopefully, after reading this, you have a better idea of how your first year of university will go. Okay, let’s get started! 

Continue reading “From One First Year Student to The Next”
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A day in the life with Amelia Guest

Interviewed and edited by Elayna Hugh-Jones

What do you study here at Newcastle University?

So I’m in my 2nd year of Biomedical science, and I’m doing a placement year in September so it’ll be a 4 year degree for me. Then I’m thinking about further study, such as a Master’s or post-grad medicine.

Newcastle University Medical School

What does a typical day look like for you?

So I’m an early bird, I get up around 6:30 and I take some time to wake up and have breakfast. Then if we have any 9am or 10am lectures I like to go to the Uni gym beforehand to start my day on a good note, which means I leave my house in Jesmond at about 7:30. We typically have 2 or 3 lectures a day and I’ll head to the Walton Library in between if we have any breaks. But if we have no lectures, Wednesdays are usually our days off, I still head to the library and set myself up for a day there. I’ll usually take my packed lunch and stay for the majority of the day and then head home for dinner. I and my housemates tend to all eat together which is a nice part of the day to look forward to.

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NuMED to Newcastle – Back to the UK… After 7 years!

“Things don’t change. We change.”

By Sabrina Amran, Third Year Biomedical Sciences student

Flatmates and I (in middle) visiting (and posing!) the med school for the first time!

The UK was a lot different in my childhood memories compared to how I see it as of now. 

Sure, ‘Wilkinsons’ became ‘Wilko’, and everything was a couple pounds cheaper 7 years ago. The weather now seemed sunnier and hotter as well…but I’m not sure how long this will last.

Continue reading “NuMED to Newcastle – Back to the UK… After 7 years!”
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So your immune system’s an overachiever; what I’m doing about it during my placement at GSK

By Emma McCarthy

“Hey, it finally worked!“

I look at the screen and smile. After an intensive six-hour lab session involving lots of careful pipetting, I’m ecstatic that the experiment I’ve spent weeks on has succeeded at last.

At the moment, I’m based in a biology research unit at GlaxoSmithKline (GSK), one of the biggest pharmaceutical companies on the planet. I’ve been on placement here for over nine months; I still can’t quite believe it some days.

Continue reading “So your immune system’s an overachiever; what I’m doing about it during my placement at GSK”