Written By Maria Kyriazi
Edited By: Elysia Marrs
Interviewed By: Elayna Hugh-Jones, Elysia Marrs
Hi Maria, what do you study here at Newcastle University?
I am an MSci Biomedical Genetics student and currently, I am undertaking my third-year Research Project for the completion of my bachelor’s degree. Therefore, I am investigating a specific protein, SGO1 and its role in female chromosomal ageing.
What is your topic of research in the lab?
My research project focuses on investigating the potential mechanisms leading to missegregation errors that are detected with the maternal age effect. For instance, after the age of 35, women are more prone to born children with chromosomal abnormalities such as Down syndrome (“trisomy 21”), or Edward’s syndrome (“trisomy 18”), which happens due to the decrease of a complex, known as cohesin, that holds sister chromatids together until the end of the second meiotic round. Essentially, I am investigating a specific protein, known as SGO1 (“shugoshin” = guardian in Japanese) that protects centromeric cohesion and, therefore, missegregation errors. My project aims to determine that this protein decreases in women after the age of 35, explaining the increased numbers of older women giving birth to children with chromosomal abnormalities after a certain age. To do so, I am using cutting edge technology, including immunofluorescence and dCas9 designed constructs which I visualize in fixed or live conditions using Zeiss LSM 880 Airyscan microscope.
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